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Items Tagged ‘Florida News Release’

June 29th, 2015 · Leave a Comment

Mayo Clinic study suggests which glioblastoma patients may benefit from drug treatment

By Kevin Punsky

Brain Cancer medical illustrationJACKSONVILLE, Fla. — Clinicians testing the drug dasatinib, approved for several blood cancers, had hoped it would slow the aggressive growth of the deadly brain cancer glioblastoma; however, clinical trials to date have not found any benefit. Researchers at Mayo Clinic, who conducted one of those clinical trials, believe they know why dasatinib failed — and what to do about it.

In the online issue of Molecular Oncology, investigators report finding that dasatinib inhibits proteins that promote cancer growth as expected but also suppresses proteins that protect against cancer.

The findings suggest that pretesting patient glioblastoma biopsies will help identify who may respond well to dasatinib and who should avoid using the drug, says the study’s senior author, Panos Z. Anastasiadis, Ph.D., chair of the Department of Cancer Biology at Mayo Clinic in Florida.

MEDIA CONTACT: Kevin Punsky, Mayo Clinic Public Affairs, 904-953-0746, punsky.kevin@mayo.edu Read the rest of this entry »

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Tags: brain cancer, Dr Jann Sarkaria, Dr Panos Z Anastasiadis, Florida, Florida News Release, glioblastoma, Mayo Clinic in Jacksonville, Medical Research, News Release, Regenerative Medicine


June 17th, 2015 · Leave a Comment

Mayo Clinic’s Pulmonary Hypertension Program Receives National Recognition

By Kevin Punsky

Mayo Clinic in Jacksonville, Fla.

JACKSONVILLE, Fla. — Mayo Clinic in Florida has been named a Pulmonary Hypertension Care Center by the Pulmonary Hypertension Association. The designation is given to centers that provide early diagnosis of pulmonary hypertension, a full range of therapies and specialized care, outcomes follow-up and clinical research and studies, among other points of excellence.

Mayo Clinic in Florida is the only Pulmonary Hypertension Care Center in the Southeast and one of only 26 in the country.

MEDIA CONTACT: Kevin Punsky, Mayo Clinic Public Affairs, 904-953-0746, punsky.kevin@mayo.edu

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Tags: Dr Charles Burger, Florida, Florida News Release, Mayo Clinic in Jacksonville, News Release, pulmonary hypertension


June 15th, 2015 · Leave a Comment

Mayo Clinic and United Therapeutics Collaborate on Lung Restoration Center

By Kevin Punsky

A rendering of the lung restoration center on the Mayo Clinic campus in Jacksonville, Florida.

A rendering of the lung restoration center on the Mayo Clinic campus in Jacksonville, Florida.

JACKSONVILLE, Fla., and SILVER SPRING, Md. — Mayo Clinic in Jacksonville, Florida, and United Therapeutics Corporation (NASDAQ: UTHR) today announced a collaboration to build and operate a lung restoration center on the Mayo campus. The goal is to significantly increase the volume of lungs for transplantation by preserving and restoring selected marginal donor lungs, making them viable for transplantation. The restored lungs will be made available to patients at Mayo Clinic and other transplant centers throughout the United States.

Construction of the center is expected to be completed in late 2017. Financial details of the agreement were not disclosed.

“This collaboration is exciting because it allows Mayo Clinic to bring the latest advances in life-saving technology to transplant patients,” says Gianrico Farrugia, M.D., chief executive officer of Mayo Clinic’s campus in Florida. “Ultimately, this relationship will help Mayo Clinic expand its reach to patients who could benefit from this innovation. Increasing the number of lungs available for transplantation provides more options for patients suffering from pulmonary disease.”

MEDIA CONTACTS:
Kevin Punsky, Mayo Clinic Public Affairs, 904-953-0746, punsky.kevin@mayo.edu;
Michael Benkowitz, United Therapeutics Corporation, 415-464-4838, mbenkowitz@unither.com

Journalists: Sound bites with Dr. Farrugia are available in the downloads.

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Tags: Dr. Gianrico Farrugia, Florida, Florida News Release, lung restoration, lung transplant, Mayo Clinic in Jacksonville, Medical Research, News Release, Regenerative Medicine, transplantation


May 30th, 2015 · Leave a Comment

Targeted Drug with Chemotherapy Combo Offers Longer Life to Patients with B-cell Cancers

By Paul Scotti

CHICAGO — Because of the significant benefit found in combining the targeted drug ibrutinib with standard chemotherapy for relapsed chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), an interim analysis has closed the international HELIOS phase III clinical trial.

Led by Mayo Clinic, researchers found that ibrutinib and chemotherapy (bendamustine and rituximab, known as BR) reduced the risk of death or cancer progression by almost 80 percent in patients with previously treated CLL or SLL, compared to use of BR alone.

MEDIA CONTACTS:
Joe Dangor (on-site at ASCO), Mayo Clinic Public Affairs, 651-261-9089 (cell), dangor.yusuf@mayo.edu.
Paul Scotti, Mayo Clinic Public Affairs, 904-953-0199 (office), scotti.paul@mayo.edu.

https://www.youtube.com/watch?v=WTNKotg-hqI

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Tags: ASCO, Asher Chanan-Khan, CLL, Florida News Release, HELIOS study, M.D., Mayo Clinic Cancer Center, Mayo Clinic in Florida, News Release, SLL


May 26th, 2015 · Leave a Comment

Shriners Hospitals for Children Joins Mayo Clinic Care Network

By Kevin Punsky

Shriners_International_Headquarters_8x10

Non-Ownership Relationship Expands Knowledge and Reach 

TAMPA, Fla.  — Mayo Clinic and Shriners Hospitals for Children today announced Shriners Hospitals for Children as a member of the Mayo Clinic Care Network, a national network of organizations committed to better serving patients and their families through physician collaboration.

The network will allow Shriners Hospitals for Children, a national health care system, to offer providers and patients convenient access to additional expertise from Mayo Clinic. The closer relationship will enhance the delivery of local care and promote peace of mind as providers and patients make health care decisions.

“With Mayo Clinic’s similar mission of providing the best care to every patient through integrated clinical practice, education and research, a relationship will give Shriners Hospitals the opportunity to further transform children’s lives,” said Dale W. Stauss, Chairman of the Board of Directors for Shriners Hospitals for Children. 

MEDIA CONTACTS:

Kevin Punsky, Mayo Clinic Public Affairs, 904-953-0746, punsky.kevin@mayo.edu
Fabiana Lowe, Shriners Hospitals for Children, 813-281-7164, filowe@shrinenet.org Read the rest of this entry »

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Tags: Children's Center, Dr. David Hayes, Florida News Release, Mayo Clinic Care Network, News Release, pediatrics, Shriners Hospitals


May 19th, 2015 · Leave a Comment

Livers Donated after Cardiac Death Safe to Use in Liver Cancer Patients

By Paul Scotti

JACKSONVILLE, Fla. — Patients with liver cancer can be cured with a liver transplant. But because of the shortage of donated organs, these patients often die waiting for a liver. That’s because most transplant centers predominantly use livers from donors who die from brain death.

But in the largest study of its kind, transplant physicians at Mayo Clinic in Florida have found that liver cancer patients have the same beneficial outcomes using organs donated by patients who died of cardiac death. The study was recently published online in the American Journal of Transplantation.

MEDIA CONTACT: Paul Scotti, Mayo Clinic Public Affairs, 904-953-0199, scotti.paul@mayo.edu

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Tags: American Journal of Transplantation, Florida News Release, Kristopher Croome, liver disease, liver transplant, M.D., Mayo Clinic in Florida, News Release, Transplant Center


May 14th, 2015 · Leave a Comment

Mayo Clinic: New Mouse Model for ALS and Frontotemporal Dementia Gene Offers Hope for Potential Therapies

By Eileen Pfaff

Pictured are nuclei (blue) of neurons in the ALS/FTD mouse model  showing they contain inclusions of both RNA (left panel, red) or poly(GA) protein (right panel, red) and TDP-43 (both panels, green).

Pictured are nuclei (blue) of neurons in the ALS/FTD mouse model showing they contain inclusions of both RNA (left panel, red) or poly(GA) protein (right panel, red) and TDP-43 (both panels, green).

JACKSONVILLE, Fla. — Researchers at Mayo Clinic in Florida have developed a mouse model that exhibits the neuropathological and behavioral features associated with the most common genetic form of amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease) and frontotemporal dementia (FTD), which are caused by a mutation in the C9ORF72 gene.

They say their findings, reported today in Science, will speed further research into the molecular mechanism behind these disorders and that the animal model will offer a way to test potential therapeutic agents to halt the death of neurons in the brain and spinal cord.

MEDIA CONTACT: Kevin Punsky, Mayo Clinic Public Affairs, 904-953-0746, punsky.kevin@mayo.edu

Journalists: Sound bites with Dr. Petrucelli are available in the downloads.

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Tags: ALS, Alzheimer’s disease, amyotrophic lateral sclerosis, Dr Dennis Dickson, Dr Kevin Boylan, Dr Leonard Petrucelli, Dr. Melissa Murray, Dr Rosa Rademakers, Florida News Release, Frontotemporal Dementia, FTD, Mayo Clinic in Florida, Medical Research, News Release


April 13th, 2015 · Leave a Comment

Creating Profile to Identify Patients Most at Risk of Developing Pancreatic Cancer

By Kevin Punsky

Endoscopic ultrasound.

The endoscope (not seen) is placed in the stomach, via the mouth. The ultrasound device, located on the tip of the scope, provides a black and white image. In this image, the normal pancreas (“panc”) is located on the right, and a large black circular cyst is seen in the center. Doppler ultrasound is used to check the nearby blood vessels such as the superior mesenteric vein (SMV) which show red blood flow.

JACKSONVILLE, Fla. — When people find out — usually from a diagnostic scan looking at something else — that they have a lesion in their pancreas that could morph into pancreatic cancer, they can panic. They insist on having frequent CT scans and biopsies to monitor the lesion, or they ask for surgery. Physicians also don’t know if these abnormalities are dangerous, so the patients end up in surgery having part of their pancreas removed. Often the lesion is nothing to worry about.

But a team of international physicians, led by researchers at Mayo Clinic’s campus in Jacksonville, Florida, has developed a profile of the patient who would be most at risk of developing lesions that are most likely to develop into cancer. Their analysis is published online today in the journal Digestive and Liver Diseases.

“The factors we found that increase risk of pancreatic cancer now allow us to separate patients as either low or high risk,” says the study’s senior author, Michael B. Wallace, M.D., MPH, a gastroenterologist at Mayo Clinic. “High-risk patients can then be scanned and biopsied more frequently or can opt for surgery, but low-risk patients don’t need such surveillance. They can be watched much less intensively.”

MEDIA CONTACT: Kevin Punsky, Mayo Clinic Public Affairs, 904-953-0746, punsky.kevin@mayo.edu

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Tags: cancer, Dr Massimo Raimondo, Dr Michael Wallace, Dr Timothy Woodward, Florida, Florida News Release, Gastroenterology, Mayo Clinic, Mayo Clinic in Jacksonville, Medical Research, News Release, Pancreatic Cancer


March 23rd, 2015 · 1 Comment

Mayo Clinic Study of Thousands of Brains Reveals Tau as Driver of Alzheimer’s Disease

By Kevin Punsky

JACKSONVILLE, Fla. — By examining more than 3,600 postmortem brains, researchers at Mayo Clinic’s campuses in Jacksonville, Florida, and Rochester, Minnesota, have found that the progression of dysfunctional tau protein drives the cognitive decline and memory loss seen in Alzheimer’s disease. Amyloid, the other toxic protein that characterizes Alzheimer’s, builds up as dementia progresses, but is not the primary culprit, they say.

The findings, published in Brain, offer new and valuable information in the long and ongoing debate about the relative contribution of amyloid and tau to the development and progression of cognitive dysfunction in Alzheimer’s, says the study’s lead author, Melissa Murray, Ph.D., a neuroscientist at Mayo Clinic in Jacksonville.

MEDIA CONTACT: Kevin Punsky, Mayo Clinic Public Affairs, 904-953-0746, punsky.kevin@mayo.edu

Journalists: Video is available in the downloads.

 

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Tags: Alzheimer’s disease, Dementia, Dr Clifford Jack, Dr David Knopman, Dr Dennis Dickson, Dr Joseph Parisi, Dr Kejal Kantarci, Dr. Melissa Murray, Dr Neill Graff-Radford, Dr Owen Ross, Dr. Ronald Petersen, Dr Val Lowe, Florida, Florida News Release, Jr, Matthew Clark PhD, Mayo Clinic Brain Bank, Mayo Clinic in Jacksonville, Mayo Clinic in Rochester, Medical Research, Minnesota, News Release


February 20th, 2015 · Leave a Comment

Mayo Clinic Researchers Identify Gene that Pushes Normal Pancreas Cells to Change Shape, a Key Step to Cancer Development

By Kevin Punsky

The image shows typical pancreatic precancerous lesions. Brown staining shows upregulation of the protein PKD1.

The image shows typical pancreatic precancerous lesions. Brown staining shows upregulation of the protein PKD1.

JACKSONVILLE, Fla. — A research team led by investigators from Mayo Clinic’s campus in Jacksonville, Florida, and the University of Oslo, Norway, have identified a molecule that pushes normal pancreatic cells to transform their shape, laying the groundwork for development of pancreatic cancer — one of the most difficult tumors to treat.

Their findings, reported in Nature Communications, suggest that inhibiting the gene, protein kinase D1 (PKD1), and its protein could halt progression and spread of this form of pancreatic cancer, and possibly even reverse the transformation.

“As soon as pancreatic cancer develops, it begins to spread, and PKD1 is key to both processes. Given this finding, we are busy developing a PKD1 inhibitor that we can test further,” says the study’s co-lead investigator, Peter Storz, Ph.D., a cancer researcher at Mayo Clinic.

MEDIA CONTACT: Kevin Punsky, Mayo Clinic Public Affairs,
904-953-0746. 
Email:punsky.kevin@mayo.edu

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Tags: cancer, Dr Peter Storz, Florida, Florida News Release, Matthew Clark PhD, Mayo Clinic in Jacksonville, Medical Research, News Release, Pancreatic Cancer