• By Dana Sparks

Discovery's Edge: Possible drug for aggression control?

January 10, 2017

a young man driving angry behind the wheel, road rage
For the first time, the stress hormone ghrelin has been linked to aggression control.

Mayo Clinic researchers say this new discovery can potentially lead to a medicine that can benefit people experiencing long term disabilities, post-traumatic stress disorder, or anxiety disorders.

Mayo Clinic and University of Minnesota researchers made the discovery while they were researching butyrylcholinesterase (BChE), a common plasma enzyme for a therapy geared towards cocaine addicts.

“The idea behind this treatment is to achieve sustained expression of a natural blood-borne enzyme that has been genetically engineered to destroy cocaine on contact and prevent it from reaching the brain, thereby eliminating its reward value,” says Mayo Clinic pharmacologist Stephen Brimijoin, Ph.D.

“Our encouraging test results in rats and mice showed that a single injection of an optimal gene transfer ‘vector’ will meet this standard, will last for years, and appears to cause zero detectable toxicity or adverse effect,” Dr. Brimijoin adds. Read the rest of the article.
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