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Endoxifen Shows Promise as Breast Cancer Treatment

Posted by Dana Sparks, Dec 11, 2013

A Phase I trial of endoxifen, an active metabolite of the cancer drug tamoxifen, indicates that the experimental drug is safe, with early evidence for anti-tumor activity. Mayo Clinic oncologist and lead author of the study Matthew Goetz, M.D., says, “We achieved up to sixtyfold higher levels of endoxifen compared to endoxifen levels achieved with the standard dose of tamoxifen. We have seen evidence for tumor regression in patients who had failed standard hormonal therapies including aromatase inhibitors, fulvestrant and tamoxifen. This is an exciting first step in the development of this drug.”

The findings indicate that Z-endoxifen, codeveloped by Mayo Clinic Cancer Center and the National Cancer Institute (NCI), may provide a new and better treatment for some women with estrogen positive breast cancer, and in particular for those who women who do not respond to tamoxifen and aromatase inhibitors. Results are being presented during the 2013 San Antonio Breast Cancer Symposium.

Click here for news release.

Journalists: Sound bites with Dr. Goetz are available in the downloads.

 

 

Tags: anti-tumor activity, Breast Cancer, Dr Matthew Goetz, endoxifen, inhibitors, national cancer institute, NCI, San Antonio Breast Cancer Symposium, Tamoxifen

 

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