• By Dana Sparks

"On-Off" Switches Could Be Used To Detect Prostate Cancer

May 14, 2012

The “on-off” switches of genes that occur early in the development of prostate cancer could be used as biomarkers to detect the disease months or even years earlier. This Mayo Clinic study found these biomarkers — known as DNA methylation profiles — also can predict if the cancer is going to recur and if that recurrence will remain localized to the prostate or, instead, spread to other organs.

The study is the first to capture the methylation changes that occur across the entire human genome in prostate cancer. It's published in the journal Clinical Cancer Research.

Soundbites from senior author, Krishna Donkena, Ph.D., available in downloads above.

Expert title for broadcast cg:
Dr. Krishna Donkena, Mayo Clinic Molecular Biologist

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