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Kevin Punsky (@kevinpunsky)

Activity by Kevin Punsky

Kevin Punsky (@kevinpunsky) posted · Thu, Dec 18 3:42pm · View  

Médicos da Mayo Clinic Afirmam que Endoscopia de alta definição avaliam pólipos com precisão e que exames patológicos caros podem não ser necessários

JACKSONVILLE, Flórida, 18 de dezembro de 2014 — Pode não ser necessário o exame patológico de pólipos removidos do cólon de um paciente, segundo um amplo estudo conduzido por médicos pesquisadores da Mayo Clinic de Jacksonville, Flórida.

O estudo com 522 pacientes, publicado na edição de dezembro do Gastrointestinal Endoscopy, revelou que os gastroenterologistas experientes podem avaliar corretamente se um pólipo é pré-canceroso ou benigno, usando lentes ópticas de alta definição durante a colonoscopia. No estudo, as análises foram de 96% a 97% precisas — dependendo de qual das duas gerações de colonoscópios foi utilizada — em comparação com uma avaliação patológica dos pólipos.

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Kevin Punsky (@kevinpunsky) posted · Wed, Dec 17 9:11am · View  

Médicos de Mayo Clinic dicen que colonoscopios de alta definición evalúan pólipos con exactitud, posiblemente convirtiendo en innecesarios a costosos exámenes patológicos

JACKSONVILLE, Florida — Los gastroenterólogos experimentados podrían no necesitar enviar a patología los pólipos extirpados del colon de un paciente, según un gran estudio realizado por médicos de Mayo Clinic en Jacksonville.

El estudio realizado en 522 pacientes y publicado en la edición de diciembre Gastrointestinal Endoscopy (Endoscopia gastrointestinal) reveló que los médicos pudieron evaluar correctamente si un pólipo era precanceroso o benigno durante la colonoscopia, gracias a lentes ópticos de alta definición. La evaluación tuvo una exactitud de 96 o 97 por ciento, dependiendo de cuál de las dos generaciones de colonoscopio se utilizó, comparado frente al examen de patología de los pólipos.

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Kevin Punsky (@kevinpunsky) posted · Tue, Dec 16 8:19am · View  

Mayo Clinic Physicians Say High-definition Scopes Accurately Assess Polyps, Costly Pathological Examinations May Not Be Necessary

JACKSONVILLE, Fla. — It may not be necessary for experienced gastroenterologists to send polyps they remove from a patient’s colon to a pathologist for examination, according to a large study conducted by physician researchers at the Jacksonville campus of Mayo Clinic.

The benign hyperplastic polyp appears very pale and bland on imaging.

The benign hyperplastic polyp appears very pale and bland on imaging.

Their 522-patient study, published in the December issue of Gastrointestinal Endoscopy, found that physicians correctly evaluated whether a polyp was precancerous or benign using high-definition optical lenses during a colonoscopy. Their assessment was 96 or 97 percent accurate — depending on which of two generations of scopes was used — compared with a standard pathological evaluation of the polyps.

The Mayo Clinic researchers conclude that the pathological polyp examination now required by national practice guidelines may not be necessary — an advance they say could result in substantial cost savings for the patient and the health care system, as well as more rapid information and recommendations for follow-up for the patient. [...]

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Kevin Punsky (@kevinpunsky) posted · Fri, Dec 12 10:46am · View  

Mayo Clinic Names Christina Zorn, J.D., as Chief Administrative Officer in Jacksonville, Florida

Christina Zorn, J.D.

Christina Zorn, J.D.

JACKSONVILLE, Fla. — Mayo Clinic has appointed Christina Zorn, J.D., as chief administrative officer of its campus in Jacksonville, Fla., and vice chair of Administration, Mayo Clinic.

She will serve as administrative partner to Gianrico Farrugia, M.D., incoming vice president of Mayo Clinic and chief executive officer of the Jacksonville campus, as previously announced. Zorn assumes her new role on Jan. 1.

“Christina Zorn has significant experience at Mayo Clinic as well as excellent insight into the strengths of Mayo Clinic’s Florida staff and the unique challenges of the local and regional market,” says Dr. Farrugia. “I look forward to working with Christina as we continue the excellent efforts underway in delivering outstanding care to our patients, advancing research and educating the next generation of providers in Florida and throughout the Southeast.”

Zorn has been with Mayo Clinic since 2002. She began her career at Mayo Clinic as a legal counsel and now serves as the chair of the Florida division of the Legal Department. In addition, Zorn has served as an administrator for the Department of Ophthalmology in Florida and for several key initiatives.

She succeeds Robert Brigham, who has served as chief administrative officer in Florida since 2005. Brigham will retire from Mayo Clinic at the end of 2014. Zorn will work closely with Brigham to ensure a smooth leadership transition.

MEDIA CONTACT: Kevin Punsky, Mayo Clinic Public Affairs, 904-953-0746,
punsky.kevin@mayo.edu [...]

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Kevin Punsky (@kevinpunsky) posted · Mon, Nov 10 9:00am · View  

Mayo Clinic Researchers Identify First Steps in Formation of Pancreatic Cancer

Shown is a region of a pancreas with preneoplastic lesions. Red labeling indicates macrophages, green labeling indicates pancreatic acinar cells that dedifferentiate, and grey labeling indicates further progressed pancreatic lesions.

Shown is a region of a pancreas with preneoplastic lesions. Red labeling indicates macrophages, green labeling indicates pancreatic acinar cells that dedifferentiate, and grey labeling indicates further progressed pancreatic lesions.

JACKSONVILLE, Fla. — Researchers at Mayo Clinic’s campus in Jacksonville say they have identified first steps in the origin of pancreatic cancer and that their findings suggest preventive strategies to explore.

In an online issue of Cancer Discovery, the scientists described the molecular steps necessary for acinar cells in the pancreas — the cells that release digestive enzymes — to become precancerous lesions. Some of these lesions can then morph into cancer.

“Pancreatic cancer develops from these lesions, so if we understand how these lesions come about, we may be able to stop the cancer train altogether,” says the study’s lead investigator, Peter Storz, Ph.D., a cancer biologist.

he need for new treatment and prevention strategies is pressing, Dr. Storz says. Pancreatic cancer is one of the most aggressive human cancers — symptoms do not occur until the cancer is well advanced. One-year survival after diagnosis is only 20 percent. It is the fourth leading cause of cancer death in this country.

The scientists studied pancreatic cells with Kras genetic mutations. Kras produces a protein that regulates cell division, and the gene is often mutated in many cancers. More than 95 percent of pancreatic cancer cases have a Kras mutation.

The researchers detailed the steps that led acinar cells with Kras mutations to transform into duct-like cells with stem cell-like properties. Stem cells, which can divide at will, are also often implicated in cancer.

MEDIA CONTACT: Kevin Punsky, Mayo Clinic Public Affairs, 904-953-0746.
Email: punsky.kevin@mayo.edu [...]

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Kevin Punsky (@kevinpunsky) posted · Mon, Oct 27 4:36pm · View  

Em mais de oito anos de tratamento do câncer de mama HER2-positivo em estágio inicial, o trastuzumabe continua a apresentar benefícios para sobrevida das pacientes

Lab image of testingJACKSONVILLE, Flórida, 21 de outubro de 2014 — Depois de acompanhar pacientes de câncer de mama por mais de oito anos, em média, pesquisadores dizem que o acréscimo do trastuzumabe (Herceptin) à quimioterapia melhorou significativamente a sobrevida das pacientes, sem a doença, de mulheres com câncer de mama HER2-positivo em estágio inicial.

Os pesquisadores descobriram que o trastuzumabe melhorou em 37% a sobrevida e 40% em redução de risco de reincidência do câncer, em comparação com as pacientes tratadas apenas com a quimioterapia. [...]

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Kevin Punsky (@kevinpunsky) posted · Mon, Oct 27 4:24pm · View  

Años después del tratamiento para el cáncer de mama HER2-positivo en etapa temprana, Trastuzumab sigue demostrando beneficios que cambian la vida

9.12.14_Genetic-TestingJACKSONVILLE, Florida — Después de hacer seguimiento a las pacientes con cáncer de mama durante un promedio de más de ocho años, los investigadores dicen que la adición de trastuzumab (Herceptin) a la quimioterapia mejoró significativamente la sobrevivencia global y libre de enfermedad de las mujeres con cáncer de mama HER2-positivo en etapa temprana.

Los expertos encontraron que el uso de trastuzumab produjo una mejoría del 37 por ciento en la sobrevivencia y una reducción del 40 por ciento en el riesgo de ocurrencia de cáncer, en comparación con las pacientes tratadas con quimioterapia sola.

Estos hallazgos, publicados en la revista, Journal of Clinical Oncology, demuestran cuán importante ha sido el trastuzumab en el tratamiento de esta forma de cáncer de mama, expresa la doctora Edith A. Perez, M.D., autora principal del estudio, directora adjunta en general del Centro Oncológico de la  Clínica Mayo y directora del Programa Traslacional de Genómica del Cáncer de Mama de la Clínica Mayo da Florida.

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Kevin Punsky (@kevinpunsky) posted · Mon, Oct 27 8:28am · View  

Transplante de Fezes Humanas: Pode Funcionar Melhor que Antibióticos

María Vázquez Roque, MD

María Vázquez Roque, MD

É difícil crer que o excremento humano possa servir para curar doenças, de maneira ainda mais eficaz que os antibióticos. No entanto, a medicina já comprovou que isso é possível, ao realizar um Transplante de Microbiota Fecal que apresentou resultados surpreendentes em pessoas que sofrem de infecção recorrente, por causa da bactéria Clostridium difficile.

As doenças gastrintestinais provocam grande deterioração na saúde das pessoas, podendo levar à morte. Muitas dessas patologias têm sua origem em uma alteração do microbioma humano ou na flora intestinal. Essa alteração pode ter múltiplas causas e pode ser responsável por outros problemas de saúde, como a obesidade, o diabetes, a aterosclerose, a síndrome da fadiga crônica e ainda problemas neurológicos, como a esclerose múltipla. Um dos problemas intestinais mais difíceis de combater e que tem sua origem nesse desequilíbrio é a infecção causada pela bactéria Clostridium difficile (CD). Hoje, há mais esperança de cura para essa doença com um transplante fecal.

Especialista no assunto, a médica María Vázquez Roque, professora assistente de gastrenterologia e hepatologia na Clínica Mayo de Jacksonville, esclarece dúvidas sobre esse tema. [...]

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