Mayo Clinic News Network

News Resources

Paul Scotti (@pscotti)

Activity by Paul Scotti

Paul Scotti (@pscotti) posted · Thu, Jun 5 2:35pm · View  

Estudo ALTTO sobre terapia combinada anti HER2, no Câncer de Mama, indica que um único agente, o Trastuzumabe, permanece como o padrão ouro de tratamento

CHICAGO — No maior estudo clínico já realizado para analisar a eficácia do tratamento do câncer de mama HER2 positivo, com um ou com a combinação de dois medicamentos, os pesquisadores relataram que o uso do lapatinibe (Tykerb) não apresentou  benefício ao tratamento auxiliar padrão com trastuzumabe (Herceptin), conforme apresentado durante o  50º encontro anual da Sociedade Americana de Oncologia Clínica (ASCO — American Society of Clinical Oncology).

Resultados do estudo clínico de fase III ALTTO (Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Study) demonstraram que ao acrescentar lapatinibe ao tratamento com trastuzimabe e quimioterapia não melhorou os resultados gerais para os pacientes (definidos como sobrevida livre da doença ou sobrevida total) e que o uso de lapatinibe aumentou de forma significativa a toxicidade do tratamento. [...]

Click here to view the rest of the post

Login here to comment.

Paul Scotti (@pscotti) posted · Thu, Jun 5 2:12pm · View  

Cáncer de mama: Estudio ALTTO sobre terapia combinada anti HER2, encuentra que agente único — el Trastuzumab — sigue siendo el mejor tratamiento estándar

CHICAGO — En el mayor estudio clínico que prueba la eficacia de un tratamiento versus dos drogas para tratar el cáncer de mama HER2-positivo, lapatinib (Tykerb ) no agregó beneficio en relación a la terapia adyuvante estándar, trastuzumab (Herceptin), según informan investigadores de la 50a reunión anual de la Sociedad Americana de Oncología Clínica (ASCO).

Los resultados del ensayo clínico de fase III, ALTTO (Estudio de Optimización de Tratamiento Adyuvante Lapatinib y/o Trastuzumab), demostraron que agregando lapatinib a trastuzumab y quimioterapia no mejoró el resultado del paciente (definido como supervivencia libre de enfermedad o supervivencia sin progresión de ésta),  y que el uso de lapatinib incrementó significativamente la toxicidad del tratamiento. [...]

Click here to view the rest of the post

Login here to comment.

Paul Scotti (@pscotti) posted · Thu, Jun 5 10:53am · View  

Tamanho do tumor é fator determinante para resposta a tratamento com medicamento promissor para tratamento de melanoma

CHICAGO — Ao examinar porque alguns pacientes com melanoma avançado respondem tão bem à imunoterapia experimental MK-3475, enquanto outros obtêm uma resposta mais fraca, pesquisadores da Clínica Mayo de Jacksonville, na Flórida, descobriram que o tamanho dos tumores, antes do tratamento, era a variável mais forte. [...]

Click here to view the rest of the post

Login here to comment.

Paul Scotti (@pscotti) posted · Thu, Jun 5 10:47am · View  

Tamaño del tumor es factor determinante en la respuesta a una promisoria droga para tratar el melanoma

CHICAGO —Al examinar por qué algunos pacientes con melanoma avanzado responden tan bien a la inmunoterapia experimental MK-3475, mientras que otros tienen una respuesta menos sólida, los investigadores de la Clínica Mayo en Jacksonville, Flórida, descubrieron que el tamaño de los tumores, antes del tratamiento, era la variable más importante. [...]

Click here to view the rest of the post

Login here to comment.

Paul Scotti (@pscotti) posted · Sun, Jun 1 7:30am · View  

ALTTO Test of Dual HER2 Blockade Finds Single Agent - Trastuzumab - Remains Gold Standard

Journalists: Broadcast soundbites with Dr. Perez are available in the downloads.

CHICAGO — In the largest clinical trial testing the effectiveness of one versus two drugs to treat HER2-positive breast cancer, lapatinib (Tykerb) did not add benefit to the standard trastuzumab (Herceptin) adjuvant therapy, researchers report at the 50th annual meeting of the American Society of Clinical Oncology (ASCO).

Results of the phase III clinical trial, ALTTO (Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization study), demonstrated that adding lapatinib to trastuzumab and chemotherapy did not improve patient outcome (defined as disease-free survival or overall survival), and that use of lapatinib significantly increased toxicity.

“These findings suggest that standard adjuvant (post-surgery) treatment for early stage HER2-positive breast cancer should remain trastuzumab in combination with chemotherapy,” says Edith A. Perez, M.D., deputy director at large of the Mayo Clinic Cancer Center, and director of the Breast Cancer Translational Genomics Program at Mayo Clinic in Florida.

Click here to view the rest of the post

Login here to comment.

Paul Scotti (@pscotti) posted · Fri, May 30 3:23pm · View  

Tumor Size is Defining Factor to Response from Promising Melanoma Drug

CHICAGO — In examining why some advanced melanoma patients respond so well to the experimental immunotherapy MK-3475, while others have a less robust response, researchers at Mayo Clinic in Florida found that the size of tumors before treatment was the strongest variable.

They say their findings, being presented June 2 at the 50th annual meeting of the American Society of Clinical Oncology (ASCO), offered several clinical insights that could lead to different treatment strategies and perhaps influence staging of advanced melanoma.

“This was the first robust assessment to determine the impact of baseline tumor size on clinical endpoints in patients with metastatic melanoma — in particular — those receiving MK-3475. Our findings suggest the location of spread is less important than the amount of tumor that is present before treatment,” says the study’s lead investigator, Richard W. Joseph, M.D., an oncologist at Mayo Clinic in Florida.

Journalists: Broadcast sound bites with Dr. Joseph are available in the downloads.



Click here to view the rest of the post

Login here to comment.

Paul Scotti (@pscotti) posted · Mon, Feb 3 3:39pm · View  

Uggie, four-legged star of the Oscar-winning film “The Artist,” to visit Mayo Clinic

JACKSONVILLE, Fla. — Feb. 3 — Uggie, the scene-stealing Jack Russell terrier in the 2012 Oscar-winning film “The Artist” will visit Mayo Clinic on Thursday, Feb. 6. Uggie will be in Jacksonville to meet Mayo’s Caring Canines, the volunteer dogs who greet patients and visitors at the clinic.

Picture of Jack Russell Terrier with black bow tieThe visit by Uggie and his owner/trainer, Omar Von Muller, is open to the public, at 12:30 p.m. Thursday in Walker Auditorium in the clinic’s Davis Building. Von Muller will share Uggie’s amazing success story of going from a puppy headed for the pound to worldwide fame. Uggie will perform some of the tricks that delighted fans of “The Artist” in which he portrayed a loyal dog who courageously rescues his owner from a fire. The film received five Oscars, including Best Picture, Best Director and Best Actor, Jean Dujardin.

There are 19 volunteer dogs in Mayo’s Caring Canines program. They make daily “meet-and-greet” visits to patients and visitors, providing warmth and unconditional love.

“The Caring Canines play a valuable role in supporting Mayo Clinic’s commitment to the healing of mind, body and spirit,” says Peter Dorsher, M.D., chair of Mayo’s Department of Physical Medicine and Rehabilitation. “Uggie’s impact on people worldwide is further evidence of the human/animal bond and how it can improve our health and well-being. We’re delighted to have him meet our volunteer dogs.” [...]

Click here to view the rest of the post

Login here to comment.

Paul Scotti (@pscotti) posted · Thu, Nov 14 2013 · View  

Blood and Marrow Transplant Program of Mayo Clinic, Nemours Children's Clinic and Wolfson Children's Hospital Earns National Accreditation Renewal

JACKSONVILLE, Fla. — The Blood and Marrow Transplantation Program of Mayo Clinic, Nemours Children's Clinic, Jacksonville, and Wolfson Children's Hospital has been awarded a three-year accreditation renewal by the Foundation for the Accreditation of Cellular Therapy (FACT). The foundation awarded the accreditation renewal after thorough site visits at all collection, transplantation and laboratory facilities at the three locations.

"We are pleased that Mayo Clinic, Nemours Children's Clinic and Wolfson Children's Hospital have met the requirements of the Foundation and have been granted accreditation for their joint Blood and Marrow Transplantation Program," said Phyllis Warkentin, M.D., FACT medical director.

"The teamwork and cooperation between all three organizations in the program has never been better," said Blood and Marrow Transplant Program Director Michael Joyce, M.D., Ph.D., a pediatric hematologist/oncologist at Nemours Children's Clinic, Jacksonville. "FACT accreditation is a promise to our patients that we are adhering to and meeting the highest standards in the field. The hematology/oncology physicians, nurses, laboratory and support staff of Nemours, Wolfson Children's and Mayo Clinic work very hard to achieve maintain these standards."

The joint program was created in 2001 to allow for greater collaboration in physician and staff expertise, research and clinical protocols. Wolfson Children's Hospital and Nemours Children's Clinic, Jacksonville, will celebrate their Blood and Marrow Transplant Program's 20th anniversary next year. Many patient referrals to the Blood and Marrow Transplant Program come from physicians in Jacksonville, across Florida and south Georgia, across the United States and internationally. Since it was established, the combined program has transplanted patients with a variety of illnesses including leukemia, neuroblastoma, sickle cell disease, bone marrow disorders, multiple myeloma, lymphoma, brain tumors, Ewing's sarcoma, and amyloidosis. Stem cell sources include the patient, immediate family members, volunteer unrelated adult marrow donors or donated umbilical cord blood donor units. More than 970 transplants have been completed during this time.

The program shares a single cryopreservation laboratory (where hematopoietic stem cells are frozen and processed) at Mayo Clinic. Mayo maintains the program's adult Blood and Marrow Transplant Unit, and Wolfson Children's Hospital maintains Pediatric Blood and Marrow Transplant beds on the Hematology/Oncology Unit in the J. Wayne and Delores Barr Weaver Tower. The joint program shares information systems, quality and other clinical and administrative staff.

"We are excited to receive this accreditation. It is a welcome recognition and 'badge of honor' for our program. It also informs and assures our patients, referring physicians and insurance companies of the highest standards of patient care and laboratory practices in our program," said Vivek Roy, M.D., hematologist/oncologist at Mayo Clinic in Florida and medical director of the adult Blood and Marrow Transplant Program.


Click here to view the rest of the post

Login here to comment.

Load More    

Loading information...