Paul Scotti (@pscotti)
Activity by Paul Scotti
JACKSONVILLE, Fla., Sept. 2, 2014 – Mayo Clinic and the University of North Florida are honoring National Breast Cancer Awareness Month in October by hosting the tenth annual “Upbeat Pink: A Musical Tribute to Breast Cancer Survivorship” concert on Friday, Oct. 10 at 7:30 p.m. in Lazzara Performance Hall, UNF Fine Arts Building on the university’s campus in Jacksonville. The Upbeat Pink concert is free and open to the public.
The theme for this year’s program, “Dancing with the Survivors,” showcases a variety of dance music performed by the UNF Wind Symphony, conducted by Gordon Brock, D.M.A., and features special guest artist and multi-instrumentalist, Bill Prince, D.M.A.
Guest speakers will include Laura Vallow, M.D., radiation oncologist at Mayo Clinic and Dianne Wagner, a local breast cancer survivor.
CHICAGO — No maior estudo clínico já realizado para analisar a eficácia do tratamento do câncer de mama HER2 positivo, com um ou com a combinação de dois medicamentos, os pesquisadores relataram que o uso do lapatinibe (Tykerb) não apresentou benefício ao tratamento auxiliar padrão com trastuzumabe (Herceptin), conforme apresentado durante o 50º encontro anual da Sociedade Americana de Oncologia Clínica (ASCO — American Society of Clinical Oncology).
Resultados do estudo clínico de fase III ALTTO (Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Study) demonstraram que ao acrescentar lapatinibe ao tratamento com trastuzimabe e quimioterapia não melhorou os resultados gerais para os pacientes (definidos como sobrevida livre da doença ou sobrevida total) e que o uso de lapatinibe aumentou de forma significativa a toxicidade do tratamento. [...]
CHICAGO — En el mayor estudio clínico que prueba la eficacia de un tratamiento versus dos drogas para tratar el cáncer de mama HER2-positivo, lapatinib (Tykerb ) no agregó beneficio en relación a la terapia adyuvante estándar, trastuzumab (Herceptin), según informan investigadores de la 50a reunión anual de la Sociedad Americana de Oncología Clínica (ASCO).
Los resultados del ensayo clínico de fase III, ALTTO (Estudio de Optimización de Tratamiento Adyuvante Lapatinib y/o Trastuzumab), demostraron que agregando lapatinib a trastuzumab y quimioterapia no mejoró el resultado del paciente (definido como supervivencia libre de enfermedad o supervivencia sin progresión de ésta), y que el uso de lapatinib incrementó significativamente la toxicidad del tratamiento. [...]
CHICAGO — Ao examinar porque alguns pacientes com melanoma avançado respondem tão bem à imunoterapia experimental MK-3475, enquanto outros obtêm uma resposta mais fraca, pesquisadores da Clínica Mayo de Jacksonville, na Flórida, descobriram que o tamanho dos tumores, antes do tratamento, era a variável mais forte. [...]
CHICAGO —Al examinar por qué algunos pacientes con melanoma avanzado responden tan bien a la inmunoterapia experimental MK-3475, mientras que otros tienen una respuesta menos sólida, los investigadores de la Clínica Mayo en Jacksonville, Flórida, descubrieron que el tamaño de los tumores, antes del tratamiento, era la variable más importante. [...]
Journalists: Broadcast soundbites with Dr. Perez are available in the downloads.
CHICAGO — In the largest clinical trial testing the effectiveness of one versus two drugs to treat HER2-positive breast cancer, lapatinib (Tykerb) did not add benefit to the standard trastuzumab (Herceptin) adjuvant therapy, researchers report at the 50th annual meeting of the American Society of Clinical Oncology (ASCO).
Results of the phase III clinical trial, ALTTO (Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization study), demonstrated that adding lapatinib to trastuzumab and chemotherapy did not improve patient outcome (defined as disease-free survival or overall survival), and that use of lapatinib significantly increased toxicity.
“These findings suggest that standard adjuvant (post-surgery) treatment for early stage HER2-positive breast cancer should remain trastuzumab in combination with chemotherapy,” says Edith A. Perez, M.D., deputy director at large of the Mayo Clinic Cancer Center, and director of the Breast Cancer Translational Genomics Program at Mayo Clinic in Florida.
CHICAGO — In examining why some advanced melanoma patients respond so well to the experimental immunotherapy MK-3475, while others have a less robust response, researchers at Mayo Clinic in Florida found that the size of tumors before treatment was the strongest variable.
They say their findings, being presented June 2 at the 50th annual meeting of the American Society of Clinical Oncology (ASCO), offered several clinical insights that could lead to different treatment strategies and perhaps influence staging of advanced melanoma.
“This was the first robust assessment to determine the impact of baseline tumor size on clinical endpoints in patients with metastatic melanoma — in particular — those receiving MK-3475. Our findings suggest the location of spread is less important than the amount of tumor that is present before treatment,” says the study’s lead investigator, Richard W. Joseph, M.D., an oncologist at Mayo Clinic in Florida.
Journalists: Broadcast sound bites with Dr. Joseph are available in the downloads.
JACKSONVILLE, Fla. — Feb. 3 — Uggie, the scene-stealing Jack Russell terrier in the 2012 Oscar-winning film “The Artist” will visit Mayo Clinic on Thursday, Feb. 6. Uggie will be in Jacksonville to meet Mayo’s Caring Canines, the volunteer dogs who greet patients and visitors at the clinic.
The visit by Uggie and his owner/trainer, Omar Von Muller, is open to the public, at 12:30 p.m. Thursday in Walker Auditorium in the clinic’s Davis Building. Von Muller will share Uggie’s amazing success story of going from a puppy headed for the pound to worldwide fame. Uggie will perform some of the tricks that delighted fans of “The Artist” in which he portrayed a loyal dog who courageously rescues his owner from a fire. The film received five Oscars, including Best Picture, Best Director and Best Actor, Jean Dujardin.
There are 19 volunteer dogs in Mayo’s Caring Canines program. They make daily “meet-and-greet” visits to patients and visitors, providing warmth and unconditional love.
“The Caring Canines play a valuable role in supporting Mayo Clinic’s commitment to the healing of mind, body and spirit,” says Peter Dorsher, M.D., chair of Mayo’s Department of Physical Medicine and Rehabilitation. “Uggie’s impact on people worldwide is further evidence of the human/animal bond and how it can improve our health and well-being. We’re delighted to have him meet our volunteer dogs.” [...]