Items tagged as "tamoxifen"
In this Mayo Clinic Radio Health Minute, Dr. Matthew Goetz comments on a study that could impact breast cancer treatment in some women. To listen, click the link below. Metabolizing TamoxifenCreated by Admin
A Phase I trial of endoxifen, an active metabolite of the cancer drug tamoxifen, indicates that the experimental drug is safe, with early evidence for anti-tumor activity. Mayo Clinic oncologist and lead author of the study Matthew Goetz, M.D., says, “We achieved up to sixtyfold higher levels of endoxifen compared to endoxifen levels [...]Created by Dana Sparks
ROCHESTER, Minn. — For nearly a decade, breast cancer researchers studying the hormone therapy tamoxifen have been divided as to whether genetic differences in a liver enzyme affect the drug's effectiveness and the likelihood breast cancer will recur. A new study by researchers from the Mayo Clinic Cancer Center and [...]Created by mayonewsreleases
A pill used for nerve pain offers women relief from hot flashes, Mayo Clinic researchers report at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO). They say the agent, pregabalin, decreased hot flash severity and frequency about 20 percent more than did a placebo agent. Thus, [...]Created by Admin
DEAR MAYO CLINIC: Why is it that some breast cancers have higher survival rates than others? ANSWER: The main reason for the difference in survival rates is that breast cancer is not just one disease. It is well accepted that there are four distinct molecular categories of breast cancer. However, new data [...]Created by Dana Sparks
Newly discovered genetic variations may help predict breast cancer risk in women who receive preventive breast cancer therapy with the selective estrogen receptor modulator drugs tamoxifen and raloxifene, a Mayo Clinic-led study has found. Mayo Clinic oncologist, James Ingle, M.D., says, “Our findings are important, because we identified genetic factors that could [...]Created by Dana Sparks
A new study confirms that a patient’s ability to metabolize the breast cancer drug tamoxifen affects the outcome of her treatment. Researchers at the Mayo Clinic Cancer Center and the Austrian Breast and Colorectal Cancer Study Group confirm that women with early breast cancer who are treated with tamoxifen and [...]Created by Dana Sparks