- News Releases
ROCHESTER, Minn. — Most patients whose breast cancer has spread to their lymph nodes have most of the lymph nodes in their armpit area removed after chemotherapy to determine if any cancer remains. A study conducted through the American College of Surgeons Oncology Group and led by Judy Boughey, M.D., a breast surgeon at Mayo Clinic, shows that a less-invasive procedure known as sentinel lymph node surgery successfully identified whether cancer remained in lymph nodes in 91 percent of patients with node-positive breast cancer who received chemotherapy before their surgery. In sentinel lymph node surgery, only a few lymph nodes, the ones most likely to contain cancer, are removed. The findings are published online in the Journal of American Medical Association. "Since treatment with chemotherapy before surgery can eliminate cancer in the lymph nodes in some patients, we were interested in evaluating whether sentinel lymph node surgery could successfully identify whether cancer remained in the lymph nodes after chemotherapy," says Dr. Boughey. Removing only a few lymph nodes reduces the risk of surgical complications such as numbness and arm swelling, she says. Researchers studied 756 women with node-positive breast cancer who received chemotherapy as an initial treatment. Of study participants, 637 patients had both sentinel lymph node and axillary lymph node surgery. Sentinel lymph node surgery correctly identified whether cancer lingered in 91 percent of patients, including 255 patients with node-negative breast cancer and 382 patients with continuing node-positive disease. Researchers also found that 40 percent of the patients had complete eradication of the cancer from the lymph nodes. The study had a false-negative rate of 12.6 percent, and the false negative rate was significantly lower with the use of dual tracers (blue dye and radiolabeled colloid) to identify the sentinel lymph nodes. Also, when more than two sentinel nodes were removed, the false-negative rate was less than 10 percent. Dr. Boughey says that technical factors in surgery are important to help ensure correct staging, especially in the setting of patients who have received chemotherapy prior to surgery. She anticipates that with appropriate patient selection, less extensive axillary surgery can be used for women who have the disease in their lymph nodes successfully eradicated by chemotherapy. The study was conducted through the American College of Surgeons Oncology Group, part of the Alliance for Clinical Trials in Oncology, and funded by the National Cancer Institute.
ROCHESTER, Minn. — Oct 1, 2013 — Mayo Clinic's Sports Medicine Center will host Ice Hockey Summit II: Action on Concussion on Oct. 8–9, 2013. The summit will bring together top scientists, trainers, coaches, officials, retired professional players and manufacturers from across the United States, Canada and Europe to discuss concussion-related issues, including the science of concussion, impact on youth athletes and hockey community response. While the summit will focus on ice hockey, concussion-related topics will apply to all sports. "This is an opportunity for experts across the hockey world to come together to make the sport safer for our athletes," says Michael Stuart, M.D., co-director, Mayo Clinic Sports Medicine Center. "Hockey players at all levels are bigger, stronger and faster. Therefore, we must improve our ability to diagnose, treat and prevent traumatic brain injury." The Mayo Clinic Sports Medicine Center is facilitating this conference with support from the Brian Mark Family Foundation,Ontario Neurotrauma Foundation, Hockey Equipment Certification Council, International Ice Hockey Federation and USA Hockey. The summit is intended to build on the first Ice Hockey Summit: Action on Concussion held in 2010. Prioritized action items from that summit helped foster mandatory concussion education for all USA Hockey coaches, improved teaching of body contact at younger ages, and rule changes, such as penalties for all hits to the head, a delay in body checking until the bantam level and the elimination of dangerous acts, such as checking from behind. As a result of these rule changes, Minnesota Hockey/Mayo Clinic Sports Medicine Center data showed a marked reduction in checking from behind penalties. At the conclusion of this year's summit, participants will again develop an updated action plan that will be shared with the hockey community.