The regenerative eye scientist, Alan Marmorstein, Ph.D., is drawn to research by the need to find new cures for diseases. As an aspiring researcher, he never envisioned his investigative journey would take him down the path of testing ways to prevent or restore loss of eyesight. However, a post-doctoral lab assignment, a National Eye Institutes grant and inspiration from retina surgeons presented him the opportunity to research disorders of the eye. It launched him on a transformative career trajectory.

“Initially, I was disappointed, because I was interested in pursuing a different line,
 says Dr. Marmorstein. “After I started working in the lab, I fell in love with the eye as a system. The eye is a unique organ in the body that you can literally look into. You can monitor what you are doing and see the effect of your research much easier than in a lot of other places in the body. It’s very easy to figure out if something can see.”

At Mayo Clinic, Dr. Marmorstein’s research to prevent blindness includes delivery of stem cell replacement therapy to slow or stop progression of diseases that rob people of their central field of vision. Mayo Clinic Center for Regenerative Medicine supports Dr. Mamorstein’s research as part of its mission to empower discovery, advance the practice and develop new cures that address unmet patient needs.

Research focus

Dr. Marmorstein’s research focuses on age-related macular degeneration and an inherited form called Best disease, which typically afflicts people under the age of 65. Macular degeneration is a loss of central vision and a leading cause of blindness in older adults. It affects more than 10 million Americans, according to the American Macular Degeneration Foundation. While there are eye injections to ease symptoms of some forms of macular degeneration, researchers are trying to solve the puzzle of how to stop the progression and ultimately cure the disease.

“The goal of our research is to keep as many people as we can from losing their central vision. Very likely any future treatments will involve a surgical intervention. We are seeking a therapy that’s off the shelf, meaning that patients can be treated readily. Our hope is that once someone is diagnosed we could immediately offer a date for surgery,” says Dr. Marmorstein.

In dry macular degeneration, the center of the retina deteriorates. With wet macular degeneration, leaky blood vessels under the retina cause blurred vision. Little is known about the cause of age-related macular degeneration. Best disease is linked to a genetic mutation affecting retinal pigment epithelial (RPE) cells, which are the layer of cells that support the health and function of light sensing cells in the retina. RPE cells are essential to maintaining vision.

Stem cell therapy

Working with the Center for Regenerative Medicine Biotrust, Dr. Marmorstein’s team is engineering replacement RPE cells derived from induced pluripotent stem cells (IPSC). The process is like turning the clock back in time to when the stem cells were first forming in the mother’s womb. At that time, cells were dividing and differentiating and could become any type of cell or tissue within the body. The human IPSCs are manufactured from tissues in the Biotrust and are reprogrammed to become retinal pigment epithelial cells that could replace the faulty cells linked to vision loss.

“The Biotrust provides us with cells from human skin samples. The expert staff at the Biotrust trained my team how to grow induced pluripotent stem cells from human samples. In addition, they provided us support in terms of finance, personnel and knowledge to do this research,” says Dr. Marmorstien.

In a further demonstration of ingenuity, Dr. Marmorstein’s team has developed a biodegradable scaffold for the delicate process of delivering the cells to the precise location within the retina where they are needed to potentially preserve or restore vision. While a plastic scaffold that would permanently remain in the eye has been used elsewhere, Mayo’s scaffold places the cell within the eye and disintegrates within two months.

“This is a unique instrument for delivering the RPE cells. The scaffold is manufactured from human fibrin, which is a protein that is naturally involved in blood clotting and wound healing,” says Dr. Marmorstein.

Dr. Marmorstein’s research team includes Jarel Gandhi, Ph.D., who designed the scaffold and Raymond Iezzi, M.D., an ophthalmologist who helped develop the surgical procedure.

A graduate of State University of New York at Albany, Dr. Marmorstein earned his Ph.D. at the State University of New York Health Science Center at Brooklyn and completed a post-doctoral fellowship at Cornell University. He began his research career at the drug company, Merck. After holding research positions at Cleveland Clinic and the University of Arizona, Dr. Marmorstein joined Mayo Clinic in 2013.

“I came to Mayo because of its unique blend of science, research, education and practice. The sharing of expertise is unmatched. I’ve had members of the retina surgical staff attending my lab meetings, and their input has been invaluable. My team draws on all available resources, such as the Biotrust, bioinformatics, biostatistics, engineering and assistance with regulatory issues to advance research,” says Dr. Marmorstein.

The key to advancing research into human clinical trials is to gain Food and Drug Administration approval for Investigational New Drug use of the RPE cells and biodegradeable scaffold in humans. Dr. Marmorstein hopes to clear that hurdle and test his research in phase 1 safety trials within 18 to 24 months.

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On the Mayo Clinic Radio program, Dr. Nipunie Rajapakse, a Mayo Clinic infectious diseases physician, offers tips for staying healthy during travel. Also on the program, Dr. Edward Laskowski, co-director of Mayo Clinic Sports Medicine, shares exercises that you can do without a gym membership. Next, Dr. Richard Daly, a Mayo Clinic cardiovascular surgeon, explains robotic mitral valve repair surgery. And, finally, Dr. Sophie Bakri, a Mayo Clinic ophthalmologist and retina specialist, discusses macular degeneration, a common eye disorder with age.

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February is coming to a close this weekend. For many Americans, March means that it’s time to escape the clutches of winter and head off on spring break. As college students and families travel to warmer climates, that also can mean spending time in close quarters with others on an airplane or cruise ship, where germs and viruses can spread. What precautions can be taken to stay healthy and avoid illness during vacation? 

On the next Mayo Clinic Radio program, Dr. Nipunie Rajapakse, a Mayo Clinic infectious diseases physician, will offer tips for staying healthy during travel. Also on the program,  Dr. Edward Laskowski, co-director of Mayo Clinic Sports Medicine, will share exercises that you can do without a gym membership. Next, Dr. Richard Daly, a Mayo Clinic cardiovascular surgeon, will explain robotic mitral valve repair surgery. And, finally, Dr. Sophie Bakri, a Mayo Clinic ophthalmologist and retina specialist, will discuss macular degeneration, a common eye disorder with age. 

To hear the program, find an affiliate in your area.

Use the hashtag #MayoClinicRadio, and tweet your questions.

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The post Mayo Clinic Radio: Staying healthy during travel appeared first on Mayo Clinic News Network.

On the next Mayo Clinic Radio program, Dr. Nipunie Rajapakse, a Mayo Clinic infectious diseases physician, will offer tips for staying healthy during travel. Also on the program,  Dr. Edward Laskowski, co-director of Mayo Clinic Sports Medicine, will share exercises that you can do without a gym membership. Next, Dr. Richard Daly, a Mayo Clinic cardiovascular surgeon, will explain robotic mitral valve repair surgery. And, finally, Dr. Sophie Bakri, a Mayo Clinic ophthalmologist and retina specialist, will discuss macular degeneration, a common eye disorder with age.

To hear the program, find an affiliate in your area.

Use the hashtag #MayoClinicRadio, and tweet your questions.

Mayo Clinic Radio is on iHeartRadio.

Access archived shows or subscribe to the podcast.

Mayo Clinic Radio produces a weekly one-hour radio program highlighting health and medical information from Mayo Clinic.

Check out the new podcast, Mayo Clinic Q&A.

The post Mayo Clinic Radio: Avoiding illness during travel / exercise without a gym / robotic mitral valve repair / macular degeneration appeared first on Mayo Clinic News Network.

On the Mayo Clinic Radio podcast, Dr. Sophie Bakri, an ophthalmologist at Mayo Clinic, explains macular degeneration and shares her new research on treatments for macular disease. Also on the podcast, Dr. Christopher Camp, an orthopedic surgeon at Mayo Clinic, discusses treatment options for frozen shoulder. And Dr. Daniel Saris, an orthopedic surgeon at Mayo Clinic, and Dr. Aaron Krych, an orthopedic and sports medicine specialist at Mayo Clinic, explain recycled cartilage auto/allo implantation, or RECLAIM — a novel stem cell therapy using regenerative medicine for knee cartilage repair.

The post #MayoClinicRadio podcast: 1/19/19 appeared first on Mayo Clinic News Network.

On this week's Mayo Clinic Radio program, Dr. Sophie Bakri, an ophthalmologist at Mayo Clinic, will explain macular degeneration and share her new research on treatments for macular disease. Also on the program, Dr. Christopher Camp, an orthopedic surgeon at Mayo Clinic, will discuss  treatment options for frozen shoulder. And Dr. Daniel Saris, an orthopedic surgeon at Mayo Clinic, and Dr. Aaron Krych, an orthopedic and sport medicine specialist at Mayo Clinic, will explain recycled cartilage auto/allo implantation, or RECLAIM — a novel stem cell therapy using regenerative medicine for knee cartilage repair.

Here's your Mayo Clinic Radio podcast.

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Macular degeneration is a common eye disease and a leading cause of vision loss among people 50 and older. With macular degeneration, the center of your retina begins to deteriorate. This causes symptoms, such as blurred central vision or a blind spot in the center of the visual field. There are two types: wet macular degeneration and dry macular degeneration. Many people will first have the dry form, which can progress to the wet form in one or both eyes. In some people, age-related macular degeneration advances so slowly that vision loss does not occur for a long time. In others, the disease progresses faster and may lead to a loss of vision in one or both eyes. Early diagnosis and treatment can help patients maintain their vision.

On this week's Mayo Clinic Radio program, Dr. Sophie Bakri, an ophthalmologist at Mayo Clinic, will explain macular degeneration and share her new research on treatments for macular disease. Also on the program, Dr. Christopher Camp, an orthopedic surgeon at Mayo Clinic, will discuss  treatment options for frozen shoulder. And Dr. Daniel Saris, an orthopedic surgeon at Mayo Clinic, and Dr. Aaron Krych, an orthopedic and sports medicine specialist at Mayo Clinic, will explain recycled cartilage auto/allo implantation, or RECLAIM — a novel stem cell therapy using regenerative medicine for knee cartilage repair.

To hear the program, find an affiliate in your area.

Use the hashtag #MayoClinicRadio, and tweet your questions.

Mayo Clinic Radio is on iHeartRadio.

Access archived shows or subscribe to the podcast.

Mayo Clinic Radio produces a weekly one-hour radio program highlighting health and medical information from Mayo Clinic.

The post Mayo Clinic Radio: Macular degeneration appeared first on Mayo Clinic News Network.

On this week's Mayo Clinic Radio program, Dr. Sophie Bakri, an ophthalmologist at Mayo Clinic, will explain macular degeneration and share her new research on treatments for macular disease. Also on the program, Dr. Christopher Camp, an orthopedic surgeon at Mayo Clinic, will discuss  treatment options for frozen shoulder. And Dr. Daniel Saris, an orthopedic surgeon at Mayo Clinic, and Dr. Aaron Krych, an orthopedic and sports medicine specialist at Mayo Clinic, will explain recycled cartilage auto/allo implantation, or RECLAIM — a novel stem cell therapy using regenerative medicine for knee cartilage repair.

To hear the program, find an affiliate in your area.

Miss the show?  Here's your Mayo Clinic Radio podcast.

Use the hashtag #MayoClinicRadio, and tweet your questions.

Mayo Clinic Radio is on iHeartRadio.

Access archived shows or subscribe to the podcast.

Mayo Clinic Radio produces a weekly one-hour radio program highlighting health and medical information from Mayo Clinic.

The post Mayo Clinic Radio: Macular degeneration / frozen shoulder / regenerative cartilage repair appeared first on Mayo Clinic News Network.

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Journalists: Sound bites with Dr. Iezzi are available in the downloads.

The post Ophthalmologist talks Glaucoma, Macular Degeneration and Diabetes appeared first on Mayo Clinic News Network.

Do you and your partner have less time for intimacy than you’d like? Mayo Clinic psychologist and certified sex therapist Dr. Jordan Rullo has tips you can use on the next Mayo Clinic Radio. Also on the program, glaucoma and macular degeneration are leading causes of blindness. We’ll talk with Mayo Clinic ophthalmologist Dr. Sophie Bakri about these and other vision problems.

Please join us!

Myth or Matter-of-Fact: Sex therapy is only for people with serious problems.

Mayo Clinic Radio is available on iHeart Radio.

Click here to listen to the program on Saturday January 31st, at 9:05 a.m. and follow #MayoClinicRadio.

Listen to this week’s Medical News Headlines: News Segment January 31, 2015  (right click MP3)

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Mayo Clinic Radio is a weekly one-hour radio program highlighting health and medical information from Mayo Clinic. The show is taped for rebroadcast by some affiliates.

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