Dr. Santhi Swaroop Vege Archives - Mayo Clinic News Network https://newsnetwork.mayoclinic.org/ News Resources Fri, 12 Jul 2024 06:42:53 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.1 5 things to know about pancreatic cancer https://newsnetwork.mayoclinic.org/discussion/science-saturday-5-things-to-know-about-pancreatic-cancer/ Fri, 18 Nov 2022 16:00:00 +0000 https://newsnetwork.mayoclinic.org/?p=329634 "It's not a particularly common cancer," says Mark Truty, M.D., a surgical oncologist at Mayo Clinic. "The lifetime risk of pancreatic cancer for any given patient without any predisposing risk is only 1 to 3%." According to the National Cancer Institute, pancreatic cancer accounts for 3.2% of all new cancer cases, but it causes nearly 8% of […]

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an older man and young boy looking at a cell phone together with a purple Pancreatic Cancer Awareness ribbon graphic

"It's not a particularly common cancer," says Mark Truty, M.D., a surgical oncologist at Mayo Clinic. "The lifetime risk of pancreatic cancer for any given patient without any predisposing risk is only 1 to 3%."

According to the National Cancer Institute, pancreatic cancer accounts for 3.2% of all new cancer cases, but it causes nearly 8% of all cancer deaths. And the five-year survival rate for pancreatic cancer is just 10.8%.

Here are five things everyone should know about this deadly cancer:

  1. Pancreatic cancer is aggressive and causes nonspecific symptoms.

"For 50% of patients at the time of their diagnosis, we find that the cancer has spread outside the pancreas to other organs, meaning stage four metastatic pancreas cancer," says Dr. Truty.

This happens for two reasons. First, pancreatic cancer cells are particularly aggressive. They accumulate and form tumors and spread to nearby organs at a rapid pace. Second, pancreatic cancer rarely causes symptoms before it has spread beyond the pancreas. And when it does cause symptoms, they are nonspecific, such as abdominal pain, back pain, or weight loss, all of which are more likely to be caused by something other than pancreatic cancer.

Read the rest of the article on the Mayo Clinic Cancer Center blog.

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Mayo Clinic Minute: Pancreatic cancer is the most lethal https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-pancreatic-cancer-is-the-most-lethal/ Fri, 26 Nov 2021 06:30:00 +0000 https://newsnetwork.mayoclinic.org/?p=322987 Pancreatic cancer can be a frightening diagnosis. Compared to most other cancers, survival rates are much lower and death often occurs at a more rapid pace. In this Mayo Clinic Minute, a leading expert in pancreatic cancer at Mayo Clinic explains more about the disease and potential future improvements in treating and screening for it. […]

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Pancreatic cancer can be a frightening diagnosis. Compared to most other cancers, survival rates are much lower and death often occurs at a more rapid pace. In this Mayo Clinic Minute, a leading expert in pancreatic cancer at Mayo Clinic explains more about the disease and potential future improvements in treating and screening for it.

Watch: The Mayo Clinic Minute

Journalists: Broadcast-quality video pkg (1:00) is in the downloads at the end of the post.
Please courtesy: "Mayo Clinic News Network." Read the script.

Pancreatic cancer is the most lethal cancer in the human body with overall five-year survival rates at just about 7 percent, despite all the advances over the past decades, says Dr. Santhi Swaroop Vege, director of the pancreatic diseases group at Mayo Clinic.

There are no telltale signs for pancreatic cancer, and symptoms like weight loss, abdominal pain, jaundice and appetite loss are nonspecific.

"That's one of the biggest problems we face," says Dr. Vege. "Usually, these people will have indigestion, acid reflux ... before finally somebody thinks of doing a CT scan. And by that time, it's already late."

He says treatments can be any combination of surgery, chemotherapy, radiation and endoscopic procedures.

"If it is localized to the pancreas and if it is not involving the major structures, then the best treatment, of course, is resection — a big surgery," says Dr. Vege.

While a standard screening test doesn't exist, Mayo Clinic researchers are diligently working on enriching patients with new-onset diabetes, along with some other features to create early screening opportunities.

________________________________

For the safety of its patients, staff and visitors, Mayo Clinic has strict masking policies in place. Anyone shown without a mask was recorded prior to COVID-19 or recorded in an area not designated for patient care, where social distancing and other safety protocols were followed.

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Mayo Clinic Q&A podcast: Pancreatic cancer is one of the deadliest forms of cancer https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-qa-podcast-pancreatic-cancer-is-one-of-the-deadliest-forms-of-cancer/ Mon, 09 Nov 2020 15:00:59 +0000 https://newsnetwork.mayoclinic.org/?p=285216 Pancreatic cancer tends to spread quickly and early detection is uncommon. For up to 50% of patients, at the time of their diagnosis, the cancer has spread outside the pancreas to other organs. Survival rates are typically 12 to 18 months, but there have been improvements in surgical techniques and chemotherapy. In this Mayo Clinic […]

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a medical illustration of pancreatic cancer

Pancreatic cancer tends to spread quickly and early detection is uncommon. For up to 50% of patients, at the time of their diagnosis, the cancer has spread outside the pancreas to other organs. Survival rates are typically 12 to 18 months, but there have been improvements in surgical techniques and chemotherapy.

In this Mayo Clinic Q&A podcast, Dr. Mark Truty, an oncology surgeon, and Dr. Santhi Swaroop Vege, a gastroenterologist, talk about treatment options, new chemotherapies, improving a patient's quality of life and the collaborative approach to team-based patient care at Mayo Clinic.


Information in this post was accurate at the time of its posting. Due to the fluid nature of the COVID-19 pandemic, scientific understanding, along with guidelines and recommendations, may have changed since the original publication date.  

For more information and all your COVID-19 coverage, go to the Mayo Clinic News Network and mayoclinic.org.

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Tinnitus and age-related hearing loss / pancreatic cancer treatments / herniated disk: Mayo Clinic Radio https://newsnetwork.mayoclinic.org/discussion/tinnitus-and-age-related-hearing-loss-pancreatic-cancer-treatments-herniated-disk-mayo-clinic-radio/ Sun, 23 Dec 2018 02:31:53 +0000 https://newsnetwork.mayoclinic.org/?p=225148 Tinnitus (TIN-ih-tus) is the perception of noise or ringing in the ears. Tinnitus is a common problem that affects about 1 in 5 people. It may affect one or both ears. The noise or ringing may be present all the time, or it may come and go. Although it can worsen with age, for many […]

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Tinnitus (TIN-ih-tus) is the perception of noise or ringing in the ears. Tinnitus is a common problem that affects about 1 in 5 people. It may affect one or both ears. The noise or ringing may be present all the time, or it may come and go. Although it can worsen with age, for many people, tinnitus can improve with treatment. Treating an identified underlying cause sometimes helps. Other treatments reduce or mask the noise, making tinnitus less noticeable.

On the next Mayo Clinic Radio program, Dr. Gayla Poling, director of Adult and Pediatric Diagnostics in Audiology at Mayo Clinic, will discuss tinnitus and other age-related hearing loss problems. Also on the program, Dr. Santhi Swaroop Vege, a gastroenterologist at Mayo Clinic, will share how new treatment protocols for pancreatic cancer are improving outcomes. And Dr. Brett Freedman, an orthopedic surgeon at Mayo Clinic, will explain treatment options for a herniated disk.

Here's your Mayo Clinic Radio podcast.

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Mayo Clinic Radio: Tinnitus and age-related hearing loss https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-radio-tinnitus-and-age-related-hearing-loss/ Thu, 20 Dec 2018 15:00:38 +0000 https://newsnetwork.mayoclinic.org/?p=224992 Tinnitus (TIN-ih-tus) is the perception of noise or ringing in the ears. Tinnitus is a common problem that affects about 1 in 5 people. It may affect one or both ears. The noise or ringing may be present all the time, or it may come and go. Although it can worsen with age, for many […]

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medical illustration of damaged hearingTinnitus (TIN-ih-tus) is the perception of noise or ringing in the ears. Tinnitus is a common problem that affects about 1 in 5 people. It may affect one or both ears. The noise or ringing may be present all the time, or it may come and go. Although it can worsen with age, for many people, tinnitus can improve with treatment. Treating an identified underlying cause sometimes helps. Other treatments reduce or mask the noise, making tinnitus less noticeable.

On the next Mayo Clinic Radio program, Dr. Gayla Poling, director of Adult and Pediatric Diagnostics in Audiology at Mayo Clinic, will discuss tinnitus and other age-related hearing loss problems. Also on the program, Dr. Santhi Swaroop Vege, a gastroenterologist at Mayo Clinic, will share how new treatment protocols for pancreatic cancer are improving outcomes. And Dr. Brett Freedman, an orthopedic surgeon at Mayo Clinic, will explain treatment options for a herniated disk.

To hear the program, find an affiliate in your area.

Miss the show?  Here's your Mayo Clinic Radio podcast.

Use the hashtag #MayoClinicRadio, and tweet your questions.

Mayo Clinic Radio is on iHeartRadio.

Access archived shows or subscribe to the podcast.

Mayo Clinic Radio produces a weekly one-hour radio program highlighting health and medical information from Mayo Clinic.

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Mayo Clinic Radio: Tinnitus and age-related hearing loss / pancreatic cancer treatments / herniated disk https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-radio-tinnitus-and-age-related-hearing-loss-pancreatic-cancer-treatments-herniated-disk/ Mon, 17 Dec 2018 16:54:46 +0000 https://newsnetwork.mayoclinic.org/?p=224465 Tinnitus (TIN-ih-tus) is the perception of noise or ringing in the ears. Tinnitus is a common problem that affects about 1 in 5 people. It may affect one or both ears. The noise or ringing may be present all the time, or it may come and go. Although it can worsen with age, for many […]

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Tinnitus (TIN-ih-tus) is the perception of noise or ringing in the ears. Tinnitus is a common problem that affects about 1 in 5 people. It may affect one or both ears. The noise or ringing may be present all the time, or it may come and go. Although it can worsen with age, for many people, tinnitus can improve with treatment. Treating an identified underlying cause sometimes helps. Other treatments reduce or mask the noise, making tinnitus less noticeable.

On the next Mayo Clinic Radio program, Dr. Gayla Poling, director of Adult and Pediatric Diagnostics in Audiology at Mayo Clinic, will discuss tinnitus and other age-related hearing loss problems. Also on the program, Dr. Santhi Swaroop Vege, a gastroenterologist at Mayo Clinic, will share how new treatment protocols for pancreatic cancer are improving outcomes. And Dr. Brett Freedman, an orthopedic surgeon at Mayo Clinic, will explain treatment options for a herniated disk.

To hear the program, find an affiliate in your area.

Use the hashtag #MayoClinicRadio, and tweet your questions.

Mayo Clinic Radio is on iHeartRadio.

Access archived shows or subscribe to the podcast.

Mayo Clinic Radio produces a weekly one-hour radio program highlighting health and medical information from Mayo Clinic.

The post Mayo Clinic Radio: Tinnitus and age-related hearing loss / pancreatic cancer treatments / herniated disk appeared first on Mayo Clinic News Network.

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Mayo Clinic Minute: Understanding pancreatic cancer https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-understanding-pancreatic-cancer/ Fri, 30 Nov 2018 07:00:27 +0000 https://newsnetwork.mayoclinic.org/?p=221184 Pancreatic cancer can be a frightening diagnosis. Compared to most other cancers, survival rates are much lower and death often occurs at a more rapid pace. In this Mayo Clinic Minute, a leading expert in pancreatic cancer at Mayo Clinic explains more about the disease and potential future improvements in treating and screening for it. […]

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Pancreatic cancer can be a frightening diagnosis. Compared to most other cancers, survival rates are much lower and death often occurs at a more rapid pace. In this Mayo Clinic Minute, a leading expert in pancreatic cancer at Mayo Clinic explains more about the disease and potential future improvements in treating and screening for it.

Watch: The Mayo Clinic Minute

Journalists: Broadcast-quality video pkg (1:00) is in the downloads at the end of the post.
Please ‘Courtesy: Mayo Clinic News Network.’ Read the script.

Pancreatic cancer is the most lethal cancer in the human body with overall five-year survival rates at just about 7 percent, despite all the advances over the past decades, says Dr. Santhi Swaroop Vege, director of the pancreatic diseases group at Mayo Clinic.

There are no telltale signs for pancreatic cancer, and symptoms like weight loss, abdominal pain, jaundice and appetite loss are nonspecific.

"That's one of the biggest problems we face," says Dr. Vege. "Usually, these people will have indigestion, acid reflux ... before finally somebody thinks of doing a CT scan. And by that time, it's already late."

He says treatments can be any combination of surgery, chemotherapy, radiation and endoscopic procedures.

"If it is localized to the pancreas and if it is not involving the major structures, then the best treatment, of course, is resection — a big surgery," says Dr. Vege.

While a standard screening test doesn't exist, Mayo Clinic researchers are diligently working on enriching patients with new-onset diabetes, along with some other features to create early screening opportunities.

The post Mayo Clinic Minute: Understanding pancreatic cancer appeared first on Mayo Clinic News Network.

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Surviving and Thriving After Life-Threatening Illnesses https://newsnetwork.mayoclinic.org/discussion/surviving-and-thriving-after-life-threatening-illnesses/ Mon, 15 Oct 2018 21:52:10 +0000 https://sharing.mayoclinic.org/?p=36979 Within the past six years, Devender Tulla developed two serious conditions that could have ended badly for the politician from India. But thanks to his Mayo Clinic care team, Devender was able to fight back. Now he's returned to work representing his constituents. For 30 years, Devender Goud Tulla, of Hyderabad, India, easily maintained the […]

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Within the past six years, Devender Tulla developed two serious conditions that could have ended badly for the politician from India. But thanks to his Mayo Clinic care team, Devender was able to fight back. Now he's returned to work representing his constituents.

Within the past six years, Devender Tulla developed two serious conditions that could have ended badly for the politician from India. But thanks to his Mayo Clinic care team, Devender was able to fight back. Now he's returned to work representing his constituents.


For 30 years, Devender Goud Tulla, of Hyderabad, India, easily maintained the active schedule of a career politician. Long days filled with speeches and public appearances required Devender to stay healthy by keeping a strict schedule of daily yoga, home-cooked meals and ample sleep.

But in October 2012, life as Devender knew it changed. During a political rally, he experienced an episode that looked like a stroke and sent him to the emergency department. It also set the wheels in motion for a journey to Mayo Clinic that spanned two oceans and several continents. At Mayo Clinic's Rochester campus, Devender received care for life-threatening conditions not once, but twice.

In November 2012, physicians at Mayo Clinic treated Devender for a rare condition known as autoimmune encephalitis. Five years later, in early 2017, Devender returned to Mayo to receive treatment for an aggressive form of non-Hodgkin's lymphoma.

"Because of Mayo Clinic and the love and affection of people there, I am here," Devender says. "I'm really thankful to Mayo Clinic and its people. They do a great service to humankind."

Today, Devender is back to work representing the people in his political district, and he has written an autobiography titled My Journey.

Sudden symptoms

Devender's health problems surfaced while he was at political event attended by 2,000 people. Suddenly dizzy and confused, he was unable to speak.

"He wasn't coherent to the people around him," says Devender's son, Vinayender Tulla, who was called immediately. A medical doctor, Vinayender suspected his father was experiencing a stroke and directed that he be taken to a hospital. There Devender received an MRI. It revealed Devender hadn't had a stroke after all.

"He had some kind of lesion on his cerebellum," Vinayender says. "That was shocking for us because right up until then, he was absolutely fine."

Complicating matters, Devender was undergoing treatment for tuberculosis at the time. His physicians were unable to pinpoint whether his symptoms were related to the tuberculosis treatment. However, to lessen the tissue inflammation surrounding the brain lesion, Devender's medical team recommended he begin taking corticosteroids.

"There was a lot of confusion, and no one could really pinpoint the diagnosis," Vinayender says. "Then one of our doctor's here in India said that, since we were unable to diagnosis him here properly, we should go to Mayo Clinic."

Disconcerting diagnosis

The family took that advice. At Mayo Clinic, Santhi Swaroop Vege, M.D. — who knows one of Devender's doctors in India — did an initial evaluation. Dr. Vege then assembled a team of specialists from the Department of Neurology and Department of Cardiovascular Medicine, among others, to hone in on Devender's illness.

Allen Aksamit Jr., M.D., a Mayo Clinic neurologist, recommended Devender be weaned off the steroids, and the team would monitor how his brain responded. That would help inform his medical team about his diagnosis. In the meantime, he was able to return home.

Back in India, Devender had another MRI in January 2013. "The inflammation actually came back," Vinayender says. "So we contacted Dr. Aksamit and told him that the disease had come back."

The family learned that the only way to confirm the nature of the lesion at that point was through a biopsy of the brain tissue. In April, Devender and Vinayender flew back to Mayo Clinic for the brain biopsy.


"He started the drug, and he started getting back to his life. 2014, 2015 and 2016 were good."

Vinayender Tulla

Neurosurgeon Fredric Meyer, M.D., joined Devender’s team to perform the biopsy. Done via stereotactic radiosurgery, the procedure involved making a small incision in the left part of Devender's cerebellum and removing a tissue sample. An evaluation of the tissue revealed the reason for Devender's lesion: autoimmune encephalitis. The condition occurs when the body’s immune system mistakenly attacks healthy brain tissue.

With a definitive diagnosis, Devender began treatment. In late 2013, he started receiving daily immunosuppression therapy to prevent his body's immune system from attacking his brain.

"He started the drug, and he started getting back to his life," Vinayender says, noting that "2014, 2015 and 2016 were good."

Additional issues

Devender returned to politics and resumed his usual activities. But near the end of 2016, he began experiencing a stuffy nose. He treated his symptoms, but by January 2017, he still couldn't breathe properly through his nose. Devender sought medical care from an otorhinolaryngologist, or ENT physician, who ordered a CT scan and an MRI. The imaging revealed that Devender had a mass in his nasal cavity that extended into the sinus cavities on either side of his nose.

"It was a huge mass, and we understood that we needed to do a biopsy of it," Vinayender says. "[The physician] suspected it to be some sort of fungal mass or nonmalignant mass. He removed the whole tumor mass and sent it for biopsy.”

The biopsy revealed Devender had diffuse large B-cell lymphoma — a form of non-Hodgkin's lymphoma where there’s a defect in the formation of antibody-producing B-cells.

The new development in his father's health prompted Vinayender to call Dr. Vege.

"We told him that there was a new diagnosis, and he asked us whether we would like to be looked at by Mayo Clinic," Vinayender says. "We didn't think twice about it."

Aggressive action

Back at Mayo Clinic, Devender again met with Dr. Vege, who had recruited Mayo Clinic hematologist Stephen Ansell M.D., Ph.D., to Devender’s medical team.

"Patients with autoimmune diseases have an ongoing inflammatory process, and when the process persistently activates the immune system, they can develop other issues related to lymphocytes," Dr. Ansell says. "In this case, it was lymphoma."

To treat the lymphoma, which had spread into nasal bone, to surrounding lymph nodes and to the testicular area, Devender was scheduled to receive six rounds of chemotherapy, followed by radiation therapy.

"Unfortunately, things didn't go according to plan," Vinayender says.

The first few days of chemotherapy, Devender seemed fine. But on the sixth day, he developed a cough with sputum. That evening, he developed a fever that rose to 103 degrees around 2 a.m. Vinayender called the care team and was directed to bring his father to Mayo Clinic Hospital — Rochester. In the Department of Emergency Medicine, Devender's blood was drawn, and his chest was X-rayed. His medical team started giving him intravenous antibiotics.

"His oxygen saturation began to fall. His vitals started to fall. His pulse increased, and his blood pressure started falling," Vinayender says. 

Extreme effects

Devender was transferred to an intensive care unit to be cared for by critical care specialists.

"He started to deteriorate really quickly, and they had to ventilate him quickly," Vinayender days. "His blood pressure fell, and they had to take corrective measures. At one point, we were really scared because his lactic acid was shooting up."

Results of blood tests showed Devender had developed numerous infections as a result of the chemotherapy weakening his immune system. On March 18, Devender's fourth day in the ICU, he became even more ill. His blood counts, especially his white blood cell count, were extremely low. The infections gripping Devender's body showed no sign of loosening.

"I was very scared. As a doctor, I knew what was happening, and it was very difficult for me to tell the same things to my brothers and mother," Vinayender says. "It was very emotionally draining because I could see that we may actually lose him because of his counts and the infection."

Making the rapid decline in Devender's health even more emotional, it was the day before his birthday. And in India, when it's the birthday of a public figure like Devender, a community of revelers gathers to celebrate the occasion.

"He's remembered well on his birthday. But here he was in the ICU, and so a lot of people were panicking and wondering what was happening," Vinayender says. "Things were very gloomy, and Dr. Vege came in and talked to me for a few minutes and encouraged me to have hope."

On Devender's birthday, the family received a special gift. His body began to fight back. His blood counts increased and signs of infection diminished. Over the next two days, Devender's team weaned him from the ventilator.

Personalized medicine

When Devender finally opened his eyes and gave a thumbs-up, his team threw him a small birthday celebration. "It was because of the people's love and affection that I could recover," Devender says.

After several additional days in the ICU, where he became more alert and active, he was transferred to a regular hospital room. Devender regained his strength, and three days later he was discharged.

After that, it was decided Devender should wait two weeks before beginning the second cycle of chemotherapy. He received that chemotherapy without incident, and he remained stable for the next six days. The seventh day, however, brought another fever and another hospitalization.


"It was because of the people's love and affection that I could recover."

Devender Goud Tulla

"But this time, it was not so serious," Vinayender says. "He did not go to the ICU. The antibiotics were given, and the very next day, the fever subsided."

Devender was given the option to return to India for the rest of his treatments. But he and his son decided it would be best to receive the third round in Minnesota, in case there were complications. That round of medicine caused a slight fever but no other effects.

"That's when we knew he was responding to the chemotherapy, and for the next cycle we went home," Vinayender says.

Ideal outcome

Back in Hyderabad, Devender completed the remaining three rounds of chemotherapy. Shortly after, he began receiving radiation therapy. When that had concluded, Devender underwent a PET scan to check for any lingering cancer. That test came back negative. Six months later, a follow-up PET scan also came back negative.

Devender Goud Tulla and Santhi Swaroop Vege, M.D.

Devender will continue to be observed and undergo regular scans to check for a cancer. But at this point, the disease is in remission.

"At Mayo Clinic, we have an integrated care process," Dr. Ansell says. "The fact that the pathologist, radiologist, radiation oncologist and hematologist are all in close proximity and work together well, along with good integration from Dr. Vege, who facilitates the care, really helped the patient get the best treatment."

If not for the support of Dr. Vege, his father likely would have had a very different outcome, Vinayender says.

"Dr. Vege has been the fulcrum for us. He introduced us to Mayo Clinic and has been not only a doctor, he's become a good friend to my father," Vinayender says. "Without him, I'm sure we would not have had the experience we had."


HELPFUL LINKS

 

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Subduing Pancreatic Cancer Involves International Odyssey https://newsnetwork.mayoclinic.org/discussion/subduing-pancreatic-cancer-involves-international-odyssey/ Mon, 17 Sep 2018 21:58:39 +0000 https://sharing.mayoclinic.org/?p=36869 When she was 38, Radhika Sattanathan received a frightening diagnosis of pancreatic cancer. Taking the advice of her physician in India, Radhika sought care halfway around the globe at Mayo Clinic. Today, she's cancer-free. Radhika Sattanathan was a young mother and wife living in Mumbai, India, when abdominal symptoms first struck her seven years ago. […]

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When she was 38, Radhika Sattanathan received a frightening diagnosis of pancreatic cancer. Taking the advice of her physician in India, Radhika sought care halfway around the globe at Mayo Clinic. Today, she's cancer-free.

When she was 38, Radhika Sattanathan received a frightening diagnosis of pancreatic cancer. Taking the advice of her physician in India, Radhika sought care halfway around the globe at Mayo Clinic. Today, she's cancer-free.


Radhika Sattanathan was a young mother and wife living in Mumbai, India, when abdominal symptoms first struck her seven years ago. A sharp, sudden pain was accompanied by hours of severe vomiting. The episode sent Radhika to a local emergency department, where she learned she had acute pancreatitis.

Radhika spent nearly two weeks in the hospital receiving treatment. Her hospitalization marked the beginning of a medical journey that lasted for years and led Radhika through a diagnosis of pancreatic cancer and, ultimately, to Mayo Clinic for pioneering treatment.

Today, Radhika is cancer-free. She attributes her good health to the support of her husband, Suresh Mahadevan, and her medical team, which included both Indian and American gastroenterologists and oncologists.

"We see many patients with pancreatic cancer who were told that their tumor is not removable and are given palliative therapy or just sent home to die," says Michael Kendrick, M.D., of Mayo Clinic's Department of Surgery. "It is very rewarding to tell patients that there is hope. While pancreatic cancer is still a difficult cancer to treat, and recurrence is common, we are making great strides. We definitely cure some and improve the quality of life and duration of life in many others."

Santhi Swaroop Vege, M.D., a Mayo Clinic gastroenterologist who collaborates with Radhika’s physician in India, says several factors contributed to Radhika’s success.

"I think one could say she probably survived because the diagnosis was made early, and the surgery was done laparoscopically, so she was able to receive the chemotherapy more quickly after surgery," Dr. Vege says. "All the planets aligned for her."

Severe situation

When Radhika had her first bout of pancreatitis in July 2011, she was 34 years old and had a 1-month-old infant. For the next two years, the disease and its symptoms — abdominal and back pain, nausea, vomiting, and fever — wreaked havoc on Radhika’s life.

In and out of the hospital 10 times in the first year alone, Radhika saw her condition improve only after she learned that fatty foods could be triggering flare-ups. By changing her diet, Radhika began managing her condition. Her frequency of hospitalizations decreased, and she learned the steps required to minimize flare-ups.

"In summer of 2013, we moved to Singapore. For two years, everything was fine," Radhika says. "I knew how to manage my body. When I started feeling the symptoms of pancreatitis, I fasted — not even consuming water — for a couple of days till the symptoms subsided."


"My husband asked the doctor what he would do, and the doctor said he would go to Mayo Clinic."

Radhika Sattanathan

But in 2015, Radhika experienced a type of abdominal pain that was new. It came on slowly and didn’t intensify when she ate or drank. Radhika soon learned it wasn't the pancreatitis. This pain was caused by a cancerous growth that had taken root in her pancreas.

Radhika consulted with her gastroenterologist in India, and she learned that her cancer required immediate surgery. He presented Radhika with three treatment options for the operation, known as the Whipple procedure. She could have the conventional, open abdominal surgery in India, receive that same surgery in Singapore, or travel to the U.S. and receive the surgery laparoscopically at Mayo Clinic.

"My husband asked the doctor what he would do, and the doctor said he would go to Mayo Clinic," Radhika says.

Less than a week later, in September 2015, Radhika and Suresh were at Mayo Clinic's Rochester campus, where Radhika was admitted to the hospital.

Tough therapy

Although Radhika’s Mayo Clinic medical team was eager to move forward with her treatment, imaging revealed that not only was the tumor large, but Radhika also had developed a blood clot in a vessel near the pancreas. The clot needed to be treated before Dr. Kendrick could perform the operation. Radhika was put on blood thinners and informed that she would need to begin chemotherapy immediately.

Radhika opted to return to Singapore for four rounds of chemotherapy. The medicine, called Folfirinox, was administered over the course of three days every 15 days. Folfirinox, says Dr. Kendrick, is among the newer chemotherapy agents used for pancreatic cancer and can be more difficult to tolerate than other drugs.

"The benefit is that it’s harder on cancer cells," Dr. Kendrick says. "So that’s why we’re seeing these remarkable responses."

Radhika recalls that the side effects of the chemotherapy were tough to take.

"For the first two days after the treatment, my tongue would go numb, and I couldn’t speak," she says. "The tastes on my tongue also went away. My body would become very stiff. I needed help to even go to the bathroom. When I washed my hands, I felt a painful, needle-poking sensation. I could not touch anything even mildly cold. I felt dizzy. I had cramps, stomach pains, vomiting, constipation, hair loss, loose stools."

In addition, Radhika’s bone marrow production slowed during her chemotherapy sessions, and her blood counts dropped. Radhika’s blood sugar levels also increased, and she required insulin shots. The first time Radhika’s parents saw her during the chemotherapy treatments, they were extremely concerned by the side effects their daughter was experiencing.

"My husband was so supportive. He told my parents not to worry," Radhika says. "He never gave up on me. He fought for me. He kept saying, 'Nothing will happen to you.'"

In December, as soon as Radhika could travel after completing her last round of chemotherapy, she and Suresh flew back to Minnesota, where she had more imaging at Mayo Clinic. The new scans revealed the tumor had decreased in size but still involved major blood vessels. Radhika’s team recommended radiation therapy as the next step.

"We were like: 'What is this? It’s the second time we’re here, and the surgery is not happening,'" Radhika says. "So we flew back to Singapore again and started doing radiation."

In addition to receiving radiation therapy, Radhika received more chemotherapy in early 2016. When the treatment was complete, Radhika’s medical team regrouped and began discussing surgery once more.

"This time, before coming, we did CT scans and sent them to Dr. Kendrick," Radhika says. "He said everything looked fine and fixed the surgery date for April 12."

Innovative operation

Radhika's surgery at Mayo Clinic involved removing one-third of her pancreas, the bile duct, the gall bladder, and the duodenum, or top part of her small intestine.

"The organs are removed, and then we use the intestine to hook everything back together," Dr. Kendrick says.

Traditionally, the Whipple procedure involves making a large incision through the abdominal wall to remove the organs and restructure a patient’s anatomy. Recovery time can range from weeks to months. Although it’s still major surgery, performing the procedure laparoscopically eases recovery significantly.

"The patient has six tiny incisions, about one-half inch in size, and they have almost no pain," Dr. Kendrick says. "Patients are walking the next day, and many are out of the hospital in five days."

In Radhika’s case, the cancer was removed, as were several lymph nodes. Although she still required follow-up treatment to make sure all cancer cells were eliminated, the surgery was a success.

"Everything went really well for her," Dr. Kendrick says. "Mayo Clinic is a world leader with this kind of surgery. We have the most experience and have advanced the technique in many ways, including use for patients with advanced pancreatic cancer."


"She really is one of these cases where she’s living and very happy, and we hope she will do well for a long time."

Santhi Swaroop Vege, M.D.

Radhika was discharged from the hospital five days after surgery. For the next month, she stayed with family members in Iowa. At her one-month follow-up appointment, Radhika was cleared to go home.

Back in Singapore, Radhika had additional chemotherapy treatments. With all her treatment now complete, Radhika checks in with her physicians every three months for blood tests and imaging exams to monitor her condition. Looking back, Radhika is amazed she came through her cancer treatment as well as she did.

"I used to give up. I cannot tolerate pain at all, and every time they used to poke me, I used to cry and cry and would say, 'I’m done,'" Radhika says. "Somehow I came out of all of that."

For as difficult as her journey was, the outcome is remarkable, Radhika’s physicians say.

"We were aggressive because of her young age," Dr. Vege says. "Today there is no evidence of cancer. Her CT scans are normal. She really is one of these cases where she’s living and very happy, and we hope she will do well for a long time."


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