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October 1st, 2014 · Leave a Comment

Mayo Researchers Awarded $2.5 Million Grant – Part of NIH BRAIN Initiative

By Dana Sparks

DBS 1Neural Engineering Laboratory at Mayo Clinic led by Kendall Lee, M.D., Ph.D, received a $2.5 million grant to develop novel methods to detect the release of neurotransmitters in the living brain. The grant is part of the National Institutes of Health’s first wave of investments totaling $46 million to support the goals of the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. The BRAIN Initiative, launched by President Obama in April 2013, strives to revolutionize our understanding of the human brain and to uncover new ways to treat, prevent, and cure brain disorders.

The Neural Engineering Laboratory collaborated with Mayo Clinic Division of Engineering to develop diamond-coated electrodes and advanced algorithms for the detection of neurotransmitters in the brain. The laboratory studies deep brain stimulation (DBS), a neurosurgical technique, used to modulate brain activity and treat patients with tremors and movement disorders.

DBS is currently approved by the U.S. Food and Drug Administration (FDA) for the treatment of movement disorders such as Parkinson’s disease but improvements in the technique such as those being pioneered at the Mayo Clinic may allow DBS to be used for the treatment of a wider variety of conditions including obsessive-compulsive disorder, Tourette’s syndrome, depression, and epilepsy.

Durability of the sensors is found to be one of the major challenges with the DBS technology, and the team has discovered that new diamond electrodes offer both the durability and sensitivity for long term sensing in the human brain, improving the outcomes for the patients.

Other collaborators on the grant include Dr. Felicia Manciu from the Physics Department at the University of Texas at El Paso, and Dr. Dong Pyo Jang from Hanyang University in Seoul, Korea.

You can find our more about the BRAIN Initiative grants here.

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Tags: DBS, Dr Kendall Lee, Neural Engineering, NIH


October 1st, 2014 · Leave a Comment

Mayo Clinic News Network — Headlines 10/1/14

By Dana Sparks


Mayo Clinic News Network Headlines include:

  • Stroke telemedicine
  • Liver transplant
  • Gluten-free diet

Journalists: Video is available in the downloads. Click here for script.

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Tags: liver transplant, Stroke Telemedicine, Gluten Free, Weekly Headlines


October 1st, 2014 · Leave a Comment

Orquestando el cuidado (y cirugía robótica) para Cáncer de Próstata

By Soledad Andrade

 

Mayo Clinic: 150 años de servicio a la humanidad, imagen del planeta 150th Sesquicentennial Logo

 

Alvaro Gomez, un director de orquesta internacionalmente conocido que reside en las afueras de Orlando, Florida, comparte su historia sobre cómo venció al cáncer de próstata. Gomez, originalmente de Chile, con raíces en España e Italia, dice que eligió Mayo Clinic en Jacksonville, Florida, en parte por sus conocimientos y por la disponibilidad de tratamientos mínimamente invasivos. Gracias al esfuerzo colaborativo de un equipo que incluyó urólogos y oncólogos, Gomez recibió el tratamiento adecuado que precisaba; y vuelve ahora a viajar por el mundo y compartir su amor por la música con las generaciones futuras.

 

JACKSONVILLE, Florida: Alvaro Gomez conoce personas en varios continentes y tiene acceso a atención médica en Estados Unidos, Chile y Europa. Cuando este residente de la región central de Florida fue diagnosticado con cáncer de próstata, pidió opiniones a amistades y médicos aquí y allá, y obtuvo una única respuesta: Mayo Clinic.

“Tuve la suerte que, después de considerar el consejo de amigos y doctores, concluí que el mejor lugar para atenderme era Mayo Clinic, a sólo una hora y media de mi casa”, dice Gomez.

Gomez lleva una ajetreada vida como violinista, profesor de música y director de orquesta en Florida, Chile, Brasil e Italia. En Florida, dirige su propia academia de música, es director de la Orquesta de Jóvenes Artistas de Florida, y enseña música en la escuela Trinity Preparatory en Winter Park. Internacionalmente, todos los años dirige la Competencia de Música Luis Sigall en Viña del Mar, en su Chile natal. Asimismo, dirige una orquesta de cámara en el Festival Villa-Lobos en Río de Janeiro, Brasil, y todos los veranos dirige en el Festival de Música Orfeo en Vipiteno, Italia.

Aunque se sentía bien, Gomez encontró tiempo dentro de su ocupada agenda para hacerse una revisión médica. Un análisis de sangre de rutina a los 56 años mostró niveles elevados de APE (antígeno prostático específico). Su médico familiar recomendó una biopsia, en la que se encontraron células cancerosas, lo que lo motivó a buscar el mejor lugar para recibir tratamiento.

“Consideré ir a Europa porque mi esposa es de Letonia”, explica Gomez. “Empero, después de comparar los volúmenes quirúrgicos de Mayo Clinic y otras instituciones, resultó indudable que debía tratarme en Mayo Clinic”, Gomez recuerda.

El Dr. Michael Wehle, cirujano urológico en Mayo Clinic de Florida, le ofreció dos opciones: extirpación tradicional de la glándula prostática o prostatectomía robotizada. En una prostatectomía robotizada (usando el robot DaVinci), el cirujano utiliza un sistema quirúrgico computarizado para extirpar la glándula prostática y los nódulos linfáticos aledaños a través de una pequeña incisión abdominal. La computadora exhibe una imagen tridimensional ampliada del área quirúrgica, permitiendo al cirujano ver el procedimiento con más detalle que en una cirugía laparoscópica tradicional. Asimismo, el método robotizado posibilita la utilización de técnicas de conservación de nervios que pueden preservar tanto la potencia sexual como la continencia. La prostatectomía robotizada permite estancias hospitalarias más cortas y recuperaciones más rápidas que la prostatectomía tradicional, explica el Dr. Wehle.

“Me siento en perfecta forma física”, afirma Gomez. “Mis actividades son exactamente las mismas que antes, mental y físicamente, y no he tenido ningún problema en lo concerniente a concentración y memorización. Me atrevería incluso a decir que estoy mejor que antes de la cirugía”.

Apenas unas semanas después de la cirugía, Gomez retomó su carrera musical viajando a Italia, como hace todos los veranos, para dirigir en el Festival de Música Orfeo en Vipiteno, en los Alpes italianos.

“Me dije que esta vez recorrería el sendero que sube a la cima de Las Dolomitas”, recuerda Gomez. El sendero montañoso implica 6 a 8 horas de caminata. “Lo hice junto a mi familia; fue un paseo maravilloso”, cuenta Gomez.

A los 62 años, Gomez continúa desafiándose a sí mismo e inspirando a otros.

“Después de recibir un diagnóstico de cáncer, miras la vida en general de una manera más positiva”, dice Gomez. “Me siento más feliz, disfruto cada momento, y comprendo que puedo canalizar todo este positivismo en enseñar a una nueva generación de músicos”.

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Información sobre Mayo Clinic
En el año 2014 se conmemoran 150 años de servicio a la humanidad de esta entidad sin fines de lucro y líder mundial en atención médica, investigación y educación. Si desea más información, visite: 150years.mayoclinic.org, MayoClinic.org/espanol o newsnetwork.mayoclinic.org/.

CONTACTO PARA LOS MEDIOS DE COMUNICACIÓN:
Soledad Andrade, Relaciones Públicas de Mayo Clinic, 507-284-5005, correo electrónico: newsbureau@mayo.edu

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Tags: Alvaro Gomez, cáncer de próstata, cirugía robótica, Clínica Mayo, DaVinci, Director de orquesta, Dr Michael Wehle, En español, espanol, Florida Central, Mayo Clinic, Orlando, spanish, Spanish News Release, Winter Park, Músicos


October 1st, 2014 · Leave a Comment

Mayo Clinic Sports Medicine Center in Downtown Minneapolis Opens Oct. 1

By Bryan Anderson

Sports Med

MINNEAPOLIS — Mayo Clinic announced today the opening of Mayo Clinic Sports Medicine Center at Mayo Clinic Square in downtown Minneapolis. Services in the new 22,000-square-foot facility include health and well-being programs, injury prevention, EXOS (formerly Athletes’ Performance) performance solutions, physical rehabilitation and sport-specific skills programs, and diagnosis and treatment of acute and chronic sports injuries for athletes of all ages.

The facility will be staffed by orthopedic and physical medicine & rehabilitation physicians, physical therapists, athletic trainers, and strength and conditioning specialists, as well as EXOS performance specialists and dietitians.

“For more than two decades, the Mayo Clinic Sports Medicine Center has provided care for professional and international sports teams, premier athletes and weekend warriors from virtually every sport,” says Jonathan Finnoff, D.O., medical director, Mayo Clinic Sports Medicine Center at Mayo Clinic Square. “Our approach to integrated, multidisciplinary care to optimize performance, minimize risk and treat injury is truly a differentiator.”sports 2

Journalists:
Sound bites and b-roll are available in the downloads.

Dr. Jonathan Finnoff
Medical Director

Dr. Nancy Cummings
Orthopedic Surgeon            

Jennifer Noiles
EXOS  Trainer           

MEDIA CONTACT: Bryan Anderson, Mayo Clinic, 507-284-5005, anderson.bryan@mayo.edu

Mayo Clinic Sports Medicine Center is a global leader in whole-person care, providing sports and musculoskeletal injury prevention and rehabilitation, concussion research, diagnostic and interventional ultrasound, and surgical and nonsurgical management of sports-related injuries.

The facility will offer performance training programs for all sports, as well as anterior cruciate ligament (ACL) injury prevention and return-to-sport rehabilitation.

To ensure athletes have tailored performance programs for all sports, Mayo Clinic is collaborating with EXOS, whose performance specialists and dietitians will be on site at Mayo Clinic Sports Medicine Center in Mayo Clinic Square. EXOS works with some of the top athletes in the world, including 105 first round National Football League draft picks and the World Cup Champion German national soccer team. Through this collaboration, Mayo Clinic Sports Medicine Center and EXOS are applying knowledge, research and innovation to advance human performance and help athletes of all ages and athletic abilities achieve their goals.Mayo view

Also being offered at Mayo Clinic Square are the latest diagnostic techniques and treatments, as well as cutting-edge technology such as a sports medicine, musculoskeletal-dedicated GE 3T wide bore magnetic resonance imaging (MRI) machine.

“Mayo Clinic provides care for tens of thousands of Twin Cities residents, and we are excited to become a member of the downtown Minneapolis community,” says John T. Wald, M.D., Mayo Clinic radiologist and medical director for marketing and public affairs. “Our long-term collaboration with the Minnesota Timberwolves and Lynx, as well as our relationships with other Twin Cities-based sports teams, will serve as a catalyst for our ongoing commitment to the community."

People who desire more information about program descriptions and/or would like to schedule an appointment can visit sportsmedicine.mayoclinic.org or call 612-313-0520.

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About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit http://www.mayoclinic.com and http://www.mayoclinic.org/news.

Journalists can become a member of the Mayo Clinic News Network for the latest health, science and research news and access to video, audio, text and graphic elements that can be downloaded or embedded.

About Mayo Clinic Sports Medicine Center
The Mayo Clinic Sports Medicine Center offers the largest, most comprehensive and leading-edge practice in the United States for the prevention and treatment of sport injuries and optimization of performance for professional, competitive and recreational athletes of all ages. For more information, please visit sportsmedicine.mayoclinic.org.

 

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Tags: Dr John Wald, Dr Jonathan Finnoff, Dr. Michael Stuart, Mayo Clinic Square, Minnesota news release, EXOS


October 1st, 2014 · Leave a Comment

Mayo Clinic, University of Mississippi Medical Center Expand Relationship With Formal Collaboration Agreement

By Elizabeth Zimmermann Young

Dr. Robert Rizza, Mayo collaboration liaison; Dr. Daniel W. Jones, UMiss Chancellor;  Dr. James Keeton, Vice Chancellor for Health Affairs/Dean of the Medical School at UMiss Medical Center (UMMC); Dr. LouAnn Woodward, Vice Dean and Associate Vice Chancellor for Health Affairs, UMMC;  Dr. Richard Summers, Associate Vice Chancellor for Research, and UMMC collaboration liaison; Dr. Gregory Gores, Executive Dean of Research, Mayo; Mr. Scott Kaese, Operations Administrator - Research, Mayo; Mr. Steven C. Smith - Chair, Department of Research Administration, Mayo.

ROCHESTER, Minn. (Sept. 30, 2014)— Drs. Charlie and Will Mayo looked approvingly over their legacy as representatives from the University of Mississippi (UMiss) and Mayo Clinic signed a formal agreement broadening and deepening their long-term relationship and opening the doors to expanded collaborations in clinical trials, other medical research and education. Shown immediately before the signing: Dr. Robert Rizza, Mayo collaboration liaison; Dr. Daniel W. Jones, UMiss Chancellor; Dr. James Keeton, Vice Chancellor for Health Affairs/CEO and Dean of the Medical School at UMiss Medical Center (UMMC); Dr. LouAnn Woodward, Vice Dean and Associate Vice Chancellor for Health Affairs, UMMC; Dr. Richard Summers, Associate Vice Chancellor for Research, and UMMC collaboration liaison; Dr. Gregory Gores, Executive Dean of Research, Mayo; Mr. Scott Kaese, Operations Administrator - Research, Mayo; Mr. Steven C. Smith - Chair, Department of Research Administration, Mayo.

University of Mississippi Medical Center logo

 

ROCHESTER, Minn. — Mayo Clinic and the University of Mississippi Medical Center (UMMC) announced today that they have signed an agreement to broaden and deepen their collaboration in clinical trials, other medical research and education. The agreement is a formal commitment to enhance the relationship that has been steadily building for the past 20 years.

“This agreement builds on our already strong relationship with the University of Mississippi Medical Center and lays the groundwork for more discovery and application,” says John Noseworthy, M.D., president and CEO, Mayo Clinic. “We’re thrilled to work even more closely to improve care for patients.”

MEDIA CONTACTS:
Elizabeth Young, Mayo Clinic, 507-284-5005, newsbureau@mayo.edu
Marc Rolph, UMMC, 601-815-5133, mrolph@umc.edu

An earlier memorandum of understanding formed an institutional bond in 2010, designed to enhance and expand shared initiatives in translational research and training. A number of cooperative clinical research relationships have flourished between Mayo and UMMC since a first collaborative study was launched in 1995 in the Genetic Epidemiology Network of Arteriopathy (GENOA), with cohorts of non-Hispanic White Americans from Rochester, Minnesota, African-Americans from Jackson, Mississippi, and Mexican-Americans from Starr County, Texas. Mayo’s and UMMC’s site principal investigators in GENOA, Stephen Turner, M.D., and Thomas Mosley, Ph.D., respectively, have continued to collaborate within GENOA, as well as in other genetic epidemiology-based research, seeking to better understand the differences in disease prevalence and progression between different racial and ethnic groups.

Daniel W. Jones, M.D., chancellor of the University of Mississippi, believes the relationship with Mayo Clinic can be transformational for the University of Mississippi Medical Center across its missions of research, education and health care.

“Expanding our existing research partnership with Mayo offers exciting possibilities for new discovery that will benefit Mississippians and people around the world,” says Dr. Jones. “Beyond that, though, the Mayo Clinic is the strongest brand in health care worldwide. We will benefit from the opportunity to apply Mayo-type approaches to management of a large, public health care enterprise such as ours. We look forward to the prospect that both partners will learn, grow and perhaps influence other public academic medical centers through this relationship.”

In addition to research into the genetic underpinnings of disease through epidemiological research, collaborative efforts between Mayo and UMMC include clinical research projects that look at genetic variations in treatment response.

“Mayo and UMMC are uniquely positioned when working together to improve our understanding of the way diseases develop and how different treatments can work among our nation’s increasingly diverse population,” says Robert Rizza, M.D., Mayo’s liaison for this collaboration. “Our combined education programs are growing as well, and we’re very excited to be exploring new avenues of understanding in such areas as rural and medically underserved communities.”

Many of the current Mayo-UMMC collaborations have been developed under the auspices of Mayo’s Center for Clinical and Translational Science (CCaTS), for which UMMC’s James Wilson, M.D., serves as an external advisory committee member. These joint activities include enabling UMMC investigators to access (currently) 26 online training modules offered by Mayo Clinic; designation of Mayo as an elite “Vanguard Center” of the UMMC-affiliated Jackson Heart Study; and a number of collaborative studies relating to kidney disease, uterine fibroids, and more.

“This is the doorway to create more exciting opportunities between UMMC and all of Mayo Clinic,” says Richard Summers, M.D., associate vice chancellor for research at UMMC, and liaison for this collaboration. “We are going to use the synergy that already exists between our organizations to take clinical research and education to a whole new level.”

Future collaborations are planned in graduate education and the mentoring and development of emerging clinical researchers, and conducting faculty exchanges. The organizations expect to leverage Mayo’s metabolomics core with UMMC’s lipidomics capabilities, share Mayo’s clinical research unit tools software, co-develop an Adult Congenital Heart Disease Clinic in Jackson, enhance UMMC’s Cardiac Electrophysiology Device Trials unit, and potentially develop a cooperative telemedicine program.

The agreement will coordinate ongoing and new complementary goals of both organizations. In the future, the closer ties between Mayo and UMMC are expected to lead to new, cutting-edge collaborations.

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About Mayo Clinic

Recognizing 150 years of serving humanity in 2014, Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit 150years.mayoclinic.org, http://www.mayoclinic.org and newsnetwork.mayoclinic.org.

About the University of Mississippi Medical Center

Located in Jackson, UMMC is Mississippi’s only academic medical center and encompasses six health science schools, including medicine, nursing, health related professions, dentistry, pharmacy and graduate studies. The Medical Center’s health care enterprise includes the state’s only level one trauma center and its only children’s hospital. The Medical Center’s education, research and health care missions share the objectives of improving the health of the state’s population and eliminating health disparities. For more information, visit http://www.umc.edu and umc.edu/news_and_publications.

 

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Tags: clinical trials, collaboration, CTSA, Diversity, education, Heart Disease, Kidney, Minnesota news release, News Release, Research, telemedicine, CCaTS, UMMC


October 1st, 2014 · Leave a Comment

New Breast Cancer Genes: Mayo Clinic Radio Health Minute

By Joel Streed

October is Breast Cancer Awareness Month.  In this Mayo Clinic Radio Health Minute, Dr. Fergus Couch comments on a recent study into the genetics of breast cancer.

To listen, click the link below.

Breast Cancer Gene Study

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Tags: Breast Cancer, Dr Fergus Couch, Mayo Clinic Radio Health Minute, podcast


October 1st, 2014 · Leave a Comment

Orchestrating Care — and Robotic Surgery — for Prostate Cancer

By Dana Sparks

'Mayo 150 years serving humanity' 150th Sesquicentennial LogoInternationally known orchestra conductor Alvaro Gomez is originally from Chile but now lives in Florida and when faced with a diagnosis of prostate cancer, he chose Mayo Clinic for his minimally invasive treatment. A collaborative team that included urologists and oncologists developed just the right treatment for Mr. Gomez, and now he's traveling the world again and sharing his love of music with future generations. [TRT 2:52]

Journalists: The video package and extra b-roll are available in the downloads. 

This is a special report produced for the Mayo Clinic 150th Anniversary Collection of Stories. To view other stories and learn about Mayo Clinic's sesquicentennial, please click here.

 

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Tags: Alvaro Gomez, DaVinci, HL, Mayo Clinic 150, Mayo Clinic Cancer Center, Pkg, Prostate Cancer, Robotic Surgery


September 30th, 2014 · Leave a Comment

CDC Confirms First Imported Case of Ebola Diagnosed in U.S.

By Dana Sparks

The Centers for Disease Control and Prevention (CDC) and Texas Health Department are confirming the first Ebola Case diagnosed in the United States. According to the CDC, the person who had traveled to Dallas, Texas from Liberia, did not have symptoms when leaving West Africa, but developed symptoms approximately four days after arriving in the U.S. on Sept. 20. Learn more about Ebola virus.

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Tags: CDC, Ebola Virus, Texas


September 30th, 2014 · Leave a Comment

Mayo Clinic Healthy Living Program Introduces Expanded Wellness Services

By Kelley Luckstein

ROCHESTER, Minn. — The Mayo Clinic Healthy Living Program, which launched earlier this year, is expanding its wellness offerings to include a weight management plan and spa services. The Healthy Weight Plan and Rejuvenate at the Mayo Clinic Healthy Living Program will open this fall and enhance the already popular wellness plans available for guests.

“We are excited about taking wellness to the next level,” says Donald Hensrud, M.D., the program’s medical director. “Our expanded services embrace the idea of involving the entire body and mind. No matter your age or health needs, if you’re looking to better manage stress, lose weight, get active, or eat and cook healthfully, our program offers a diverse selection of wellness options for anyone seeking whole-body wellness.”
Grocery bag with healthy foods and weight scale

Healthy Weight Plan
Losing weight and making lifestyle changes can feel overwhelming. Mayo experts understand this challenge. The plan brings together the collective knowledge of weight management and behavior change experts. They have developed a two-day on-site session, along with engagement before and after the on-site program that breaks down barriers, dispels diet myths and guides guests on a weight-loss journey tailored specifically to their goals. The plan also offers ongoing support so guests stay motivated and the weight stays off for good.

“An important aspect of this program is that Mayo Clinic staff understand how challenging weight management can be and they offer a strong supportive environment while people meet these challenges,” says Dr. Hensrud. “Everyone has different obstacles to weight management, and we encourage guests to design their own individualized weight-loss program to address these obstacles.”

Our wellness specialists stay engaged as partners for a full year to help people meet their healthy weight goals, Dr. Hensrud adds.

Rejuvenate at the Mayo Clinic Healthy Living Program

Frosted glass door with the words Rejuvenate at the Mayo Clinic Healthy Living ProgramMayo Clinic has long offered massage, acupuncture, meditation training and skin care services as key components of patient care in the hospital and clinical setting. It is now using that knowledge and expertise to offer spa services at Rejuvenate at the Mayo Clinic Healthy Living Program.

“We have created a true lifestyle-changing program that blends together evidenced-based health and spa therapies to support people’s wellness journey,” says Brent Bauer, M.D., medical director, Rejuvenate at the Mayo Clinic Healthy Living Program. “Rejuvenate emphasizes the ways that traditional spa services can enhance a person’s overall well-being through the renewal of mind, body and spirit.”

The therapies provided can be enjoyed on their own or complement a person’s wellness experience at the Mayo Clinic HealthyPedicure chairs and tubs at Rejuvenate at the Mayo Clinic Healthy Living Program. Living Program. Services offered include an array of massages, skin care (facials, microdermabrasion, chemical peels, injectables) and nail health such as manicures and pedicures (no gels or artificial nails).

For information on the new services and to contact or schedule an appointment, please visit the Mayo Clinic Healthy Living Program website: https://healthyliving.mayoclinic.org/.

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About Mayo Clinic
Recognizing 150 years of serving humanity in 2014, Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit150years.mayoclinic.org, http://www.mayoclinic.org/ and newsnetwork.mayoclinic.org.

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About the Mayo Clinic Healthy Living Program
The Mayo Clinic Healthy Living Program is redefining healthy living. It’s a comprehensive, whole-body wellness experience guided by medical research and evidence-based medicine to offer guests trusted solutions to improve quality of life. The program is research-driven around diet, exercise, and resiliency; and when all of these are connected, they encompass the power needed to make sustainable changes. Wellness coaches work with individuals to design comprehensive, personalized wellness plans based on goals and expectations. Ongoing support is offered to ensure continued success and sustainability once guests return home. Cooking demonstrations, physical activities, resiliency experiences and spa services are available to guests, patients and family members through our à la carte menu. Located in Rochester, Minnesota, the Mayo Clinic Healthy Living Program is close to a local airport and is within an hour and fifteen-minute drive of Minneapolis.

MEDIA CONTACT: Kelley Luckstein, Mayo Clinic Public Affairs, 507-284-5005 or newsbureau@mayo.edu

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Tags: acupuncture, Dr. Brent Bauer, Dr. Donald Hensrud, massage, meditation training, Minnesota news release, News Release, Skin Care, stress, Weight Loss, Wellness


September 30th, 2014 · Leave a Comment

Dados de estudos clínicos mundiais de dois medicamentos para câncer de mama HER2-positivo mostra que o trastuzumabe deve permanecer como o padrão de tratamento

By Paul Scotti

JACKSONVILLE, Flórida 30 de setembro de 2014 — Análises em mais de 8 mil mulheres, que participaram do maior estudo mundial de dois medicamentos para o câncer de mama HER2-positivo, reforçam outras descobertas de estudos clínicos mostrando que o trastuzumabe (Herceptin) deve permanecer como o padrão de tratamento desse tipo de câncer, diz uma pesquisadora da Clínica Mayo.

O estudo, apresentado no Congresso da Sociedade Europeia para Oncologia Clínica (ESMO — European Society for Medical Oncology) de 2014, em Madri, revela que, quando usado como terapia única para combater o HER-2 em adição à quimioterapia padrão, o trastuzumabe oferece um resultado melhor do que o lapatinibe (Tykerb), diz a vice-diretora geral do Centro de Câncer da Clínica Mayo, Edith A. Perez, que também é diretora do Programa de Genômica Translacional do Câncer de Mama da Clínica Mayo da Flórida.

Edith Perez é copresidente do estudo “Otimização do Tratamento Adjuvante com Lapatinibe e/ou Trastuzumabe” (ALTTO — Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization study). A fase III do estudo clínico, que testou combinações de dois medicamentos ou uso de medicamentos por elas mesmas – em acréscimo à quimioterapia padrão – inscreveu 8.381 participantes e 946 centros médicos em 44 países.

Uma descoberta essencial do ALTTO, divulgado em junho, mostrou que o lapatinibe, quando usado em acréscimo ao trastuzumabe como parte da terapia dupla, não ofereceu qualquer benefício estatisticamente significativo às pacientes, tais como sobrevivência sem a doença ou sobrevivência geral. O bloqueio duplo, usando dois medicamentos contra o HER2, apenas aumenta a toxicidade, diz Edith Perez.

Essa nova análise comparou o uso do lapatinibe ou trastuzumabe apenas, bem como o resultado em pacientes sem a doença, às quais foi administrado trastuzumabe, como tratamento adjuvante, depois de serem tratadas com lapatinibe apenas.

Os pesquisadores descobriram que o trastuzumabe ofereceu um resultado melhor, comparado ao uso do lapatinibe apenas. Depois de 4,5 anos de acompanhamento, 14% das pacientes que usaram o trastuzumabe experimentaram pelo menos um evento da doença, em comparação com 18 por cento das pacientes que usaram o lapatinibe. Um evento da doença é definido como uma recorrência do câncer de mama em qualquer parte do corpo, um novo câncer ou morte de qualquer causa.

No entanto, a segurança cardíaca foi boa nos dois grupos e não houve diferença no índice de desenvolvimento de metástase no cérebro, diz Edith Perez.

Os pesquisadores também mostraram que a mudança do lapatinibe para o trastuzumabe ofereceu um benefício às pacientes. Das 2.100 pacientes no grupo do lapatinibe, 52 por cento receberam pelo menos uma dose de trastuzumabe.

“Ficamos satisfeitos por haver recebido uma notificação antecipada, em agosto de 2011, sobre o menor benefício potencial do lapatinibe em comparação com o trastuzumabe, o que nos levou a administrar o trastuzumabe aos pacientes que foram tratados como o lapatinibe apenas. Essa intervenção mostra bem nossa flexibilidade na condução de estudos clínicos”, diz Edith Perez.

“O estudo ALTTO foi e ainda é um estudo clínico global muito importante. Todas as pacientes foram controladas cuidadosamente e nós demonstramos resultados gerais melhores do que o esperado”, ela diz. “Demonstramos que a atividade do lapatinibe pareceu ser menor do que o apresentando pelo trastuzumabe no cenário adjuvante, que havia uma tendência para benefícios adicionais se aquelas pacientes fossem tratadas com o trastuzumabe, que a segurança cardíaca era melhor do que o previsto e que o número de metástases no cérebro pareceu similar para as pacientes que receberam o lapatinibe ou o trastuzumabe”.

Edith Perez acrescenta que as pacientes ainda são acompanhadas e que a equipe de pesquisa está investigando espécimes de tumor e de sangue para descobrir e analisar possíveis biomarcadores para um tratamento eficaz.

O estudo foi financiado pelo Intergrupo do Câncer de Mama da América do Norte (TBCI — The Breast Cancer Intergroup of North America), sediado nos Estados Unidos, pelo Grupo Internacional do Câncer de Mama (BIG — Breast International Group) de Bruxelas, Bélgica, pelo Instituto Nacional do Câncer e pela Glaxo SmithKline. O TBCI é composto por seis grupos cooperativos de estudos clínicos financiados pelo NCI, que, por sua vez, faz parte dos Institutos Nacionais de Saúde.

Para mais informações sobre tratamento do câncer de mama e outros tipos de câncer na Clínica Mayo de Jacksonville, Flórida, contate o departamento de Serviços Internacionais pelo telefone 1-904-953-7000 ou envie e-mail para intl.mcj@mayo.edu. Para mais informações em português, visite mayoclinic.org/portuguese/.

Sobre a Mayo Clinic
Completando 150 anos de serviços à humanidade em 2014, a Mayo é uma das principais clínicas mundiais, dedicada à atenção médica, pesquisa e educação para pessoas em todas as etapas da vida.  Não tem fins lucrativos. Para mais informações, acesse 150years.mayoclinic.org ou newsnetwork.mayoclinic.org/.

Sobre o Centro de Câncer da Clínica Mayo
O Centro de Câncer da Clínica Mayo (Mayo Clinic Cancer Center), uma instituição proeminente, financiada pelo Instituto Nacional do Câncer, conduz pesquisas básicas, clínicas e de ciências da população, traduzindo descobertas em métodos aperfeiçoados de prevenção, diagnóstico, prognóstico e terapia do câncer. Para mais informações sobre estudos clínicos do câncer, telefone para 507-538-7623.

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CONTACTO: Guta Bacelar, 305-598-0125, gbacelar@bellsouth.net

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