November 24th, 2014 · Leave a Comment
By Dennis Douda
As the number one cancer killer, lung cancer claims more lives than breast, prostate and colon cancers combined. To help detect it sooner, when it’s far more treatable, Mayo Clinic has launched a Lung Cancer Screening Program. For some, the process is already proving to be a life saver. [TRT: 3:00]
Those wishing to contact Mayo Clinic’s Lung Cancer Screening Program in Rochester, Minn., may call 507-538-0340.
Journalists: A broadcast quality video package and additional b-roll are available in the downloads. To access the script, click here.
This is a special report produced for the Mayo Clinic 150th Anniversary Collection of Stories. To view other stories and learn about Mayo Clinic's sesquicentennial, please click here.
November 13th, 2014 · Leave a Comment
By Bob Nellis
ROCHESTER, Minn. — One of the family of drugs prescribed for rheumatoid arthritis and other inflammatory conditions is called TNF inhibitors. They act by dampening part of the immune system called tumor necrosis factor (TNF). In one of the balancing acts of medicine, the anti-inflammatory action of the drug also increases the risk for other conditions, in this case, a rare form of eye cancer, uveal melanoma. Mayo Clinic researchers make the case and alert physicians in an article in Mayo Clinic Proceedings.
Mayo researchers studied three patients — two women and a man — who were treated for inflammatory disease and developed melanoma tumors in one eye within a year to two of taking TNF inhibitors. While this type of condition is probably rare, according to the researchers, there might be an increased risk if the patient has a pre-existing nevus (freckle of the eye). The women had inflammatory bowel disease; the man had rheumatoid arthritis. The studies occurred between 2009 and 2013.
Researchers say that patients considered for treatment with TNF inhibitors should first be given an eye exam to determine eye health, and any with existing conditions, such as choroidal nevus (lesions on the eye), should be monitored regularly to determine if any issues are developing.
September 30th, 2014 · Leave a Comment
By Brian Kilen
ROCHESTER, Minn. ― Here are highlights from the September issue of Mayo Clinic Health Letter. You may cite this publication as often as you wish. Reprinting is allowed for a fee. Mayo Clinic Health Letter attribution is required. Include the following subscription information as your editorial policies permit: Visit http://www.HealthLetter.MayoClinic.com or call toll-free for subscription information, 1-800-333-9037, extension 9771. Full newsletter text: Mayo Clinic Health Letter September 2014 (for journalists only).
Adjusting from being a cancer patient to a cancer survivor isn't just about celebration and gratitude. The September issue of Mayo Clinic Health Letter covers why this transition isn’t always smooth or easy. In addition to dealing with fatigue or other side effects of surgery or treatment, patients may be surprised by feelings that can include fear and uncertainty, anxiety, sadness and irritability.
June 26th, 2014 · Leave a Comment
By Sam Smith
ROCHESTER, Minn. — A Mayo Clinic-led group of researchers has discovered three subgroups of a single type of non-Hodgkin lymphoma that have markedly different survival rates. These subgroups could not be differentiated by routine pathology but only with the aid of novel genetic tests, which the research team recommends giving to all patients with ALK-negative anaplastic large-cell lymphoma (ALCL). Findings are published in the journal Blood.
Journalists: Sound bites with Dr. Feldman are available in the downloads.
Patients whose lymphomas had TP63 rearrangements had only a 17 percent chance of living five years beyond diagnosis, compared to 90 percent of patients whose tumors had DUSP22 rearrangements. A third group of tumors, those with neither rearrangement, was associated with an intermediate survival rate. Read the rest of this entry »
June 12th, 2014 · Leave a Comment
By Bob Nellis
Potentially disfiguring facial tumor caused by chromosomal chimera
ROCHESTER, Minn. — This is the story of two perfectly harmless genes. By themselves, PAX3 and MAML3 don’t cause any problems. However, when they combine during an abnormal but recurring chromosomal mismatch, they can be dangerous. The result is a chimera — a gene that is half of each — and that causes biphenotypic sinonasal sarcoma. The tumor usually begins in the nose and may infiltrate the rest of the face, requiring disfiguring surgery to save the individual. Because Mayo Clinic pathology researchers have now described the molecular makeup of the rare tumor, several existing cancer drugs may be targeted against it. The findings appear in the current issue of Nature Genetics.
Tags: Andre Oliveira, cancer, chromosomal chimera, fusion gene, Head and Neck Cancer, Jean Lewis, MAML3, Mayo Clinic, Mayo Clinic in Rochester, Nature Genetics, News Release, pathology, PAX3, rearrangement, Research, Rochester news release, sarcoma, sinonasal, translocation
June 4th, 2014 · Leave a Comment
By Bob Nellis
ROCHESTER, Minn. — Researchers at Mayo Clinic have demonstrated in a mouse model that their recently developed synthetic peptide carrier is a potential delivery vehicle for brain cancer chemotherapy drugs and other neurological medications. The findings appear in PLOS ONE.
“Not only have we shown that we can transport eight different molecules, we think this method will be less disruptive or invasive because it mimics a normal physiological process,” says Mayo Clinic neuroscientist Gobinda Sarkar, Ph.D., the corresponding author of the study. The researchers are able to transport the drugs without modifying any of the molecules involved. They say this development will aid in evaluation of potential new drugs for brain cancer.
The blood-brain barrier is meant to protect the brain from numerous undesirable chemicals circulating in the body, but it also obstructs access for treatment of brain tumors and other conditions. Too often the only recourse is invasive, which often limits a drug’s effectiveness or causes irreversible damage to an already damaged brain. Nearly all of the drugs that could potentially help are too large to normally pass through the barrier. Additionally, other methods may damage the vascular system.
Read the rest of this entry »
Tags: BBB, blood brain barrier, brain cancer, cancer, Chemotherapy Drugs, Dr Gobinda Sarkar, Dr Robert Jenkins, I-125, K16ApoE, Mayo Clinic, Minnesota news release, News Release, PLoS One, synthetic peptide carrier
June 2nd, 2014 · Leave a Comment
PHOENIX — A promising new study from Mayo Clinic, in conjunction with Caris Life Sciences, points to immunotherapy as a possible treatment option for patients with the difficult-to-treat triple negative breast cancer mutation. The study was presented this week at the 50th annual meeting of the American Society of Clinical Oncology in Chicago.
“This study may change our ability to treat triple negative breast cancer patients,” says Barbara Pockaj, M.D., lead investigator of the study and Mayo Clinic surgeon. “We may have signs that these patients can be treated with immunotherapy. We don’t have a lot of options for these patients and this would really expand our options.” Read the rest of this entry »
Tags: American Society of Clinical Oncology, Arizona News Release, ASCO, Barbara Pockaj, Breast Cancer, cancer, Caris Life Sciences, Chemotherapy, HER2, immunotherapy, Lung Cancer, MD, Mayo Clinic, Mayo Clinic Arizona, Melanoma, PD-L1, Renal Cell Carcinoma
May 16th, 2014 · Leave a Comment
By Bob Nellis
ROCHESTER, Minn. — May 14, 2014 — In a proof of principle clinical trial, Mayo Clinic researchers have demonstrated that virotherapy — destroying cancer with a virus that infects and kills cancer cells but spares normal tissues — can be effective against the deadly cancer multiple myeloma. The findings appear in the journal Mayo Clinic Proceedings.
Journalists: The video package and extra b-roll are available in the downloads. The video package script, including intro and anchor tags, is available here.
Two patients in the study received a single intravenous dose of an engineered measles virus (MV-NIS) that is selectively toxic to myeloma plasma cells. Both patients responded, showing reduction of both bone marrow cancer and myeloma protein. One patient, a 49-year-old woman, experienced complete remission of myeloma and has been clear of the disease for over six months.
“This is the first study to establish the feasibility of systemic oncolytic virotherapy for disseminated cancer,” says Stephen Russell, M.D., Ph.D., Mayo Clinic hematologist, first author of the paper and co-developer of the therapy. “These patients were not responsive to other therapies and had experienced several recurrences of their disease.”
Multiple myeloma is a cancer of plasma cells in the bone marrow, which also causes skeletal or soft tissue tumors. This cancer usually responds to immune system-stimulating drugs, but eventually overcomes them and is rarely cured.
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March 20th, 2014 · Leave a Comment
By Bob Nellis
Laser-guided Malaria Detectors
Smart Socks that Predict Heart Attacks
Mouse Avatars to Study Ovarian Cancer
These are just three of the joint projects now underway involving collaborative research teams from Mayo Clinic and the University of Minnesota. Over $4 million in research awards from the Minnesota Partnership for Biotechnology and Medical Genomics will make those investigative projects possible. The research grants are intended to jump start innovative ideas and generate scientific data in order to secure more long-term funding. These "seed" grants are for two years and involve ideas that have a strong likelihood of turning into marketable products or processes.
The other three projects include development of a genomic research tool to help scientists engineer DNA, a study looking for links between stress and obesity, and an exploration of the causes of and possible therapies for irritable bowel syndrome involving microbiotics. The funding comes from the state of Minnesota.
Read entire news release.