• By Deb Balzer

Mayo Clinic to offer COVID-19 vaccination clinics in Rochester

October 22, 2021
a Black woman, Mayo Clinic nurse or medical tech person, wearing a mask and holding a COVID-19 vaccine syringe

Learn where you can get initial and booster vaccinations, and third doses, Oct. 22- Dec. 3

Mayo Clinic in Rochester will offer COVID-19 vaccine clinics for patients, visitors and community members through Dec. 3.

Pfizer and Moderna booster vaccinations

Pfizer and Moderna booster vaccinations will be offered to people who received a Moderna or Pfizer COVID-19 initial vaccination series, as directed by the Food and Drug Administration.

A booster vaccination is recommended six months after the initial vaccination series for these groups:

  • People 65 and older. 
  • People 18–64 who are at high risk of severe COVID-19 infection.
  • Ages 18–64 living with or caring for someone with a medical condition that puts them at high risk of severe COVID-19 infection.
  • People 18–64 with frequent institutional or occupational exposure to COVID-19 that puts them at high risk of serious complications of COVID-19, including severe COVID-19 infection. This group includes health care workers, teachers and day care staff, grocery workers, and those in homeless shelters or prisons.

J&J booster vaccinations

Johnson & Johnson COVID-19 booster vaccinations will be offered to people ages 18 and older starting two months after completion of the primary Johnson & Johnson COVID-19 vaccine.

Please note, Moderna and Johnson & Johnson booster vaccinations are scheduled to be available the week of Oct. 25 however the exact date is yet to be determined. If you are looking to receive the Moderna or Johnson & Johnson booster vaccine attending a clinic later in the week may be beneficial.

Oct. 22 – Dec. 3

3033 41st NW, Center Building, north entrance, first floor

At this location, initial or subsequent COVID-19 vaccinations, third COVID-19 doses for immunocompromised people, COVID-19 booster vaccinations will be available on these dates:

  • Oct. 18, Oct. 20 & Oct. 22: 7:30 a.m. to 5 p.m.
  • Oct. 19 & Oct. 21: 7:30 a.m. to 7 p.m.
  • Oct. 25, Oct. 27 & Oct. 29: 7:30 a.m. to 5 p.m.
  • Oct. 26 & Oct. 28: 7:30 a.m. to 7 p.m.
  • Oct. 23, Oct. 30 (Saturdays): 8 a.m. to noon
  • Nov. 1, Nov. 3 & Nov. 5: 7:30 a.m. to 5 p.m.
  • Nov. 2 & Nov. 4: 7:30 a.m. to 7 p.m.
  • Nov. 6 (Saturday): 8 a.m. to noon
  • Nov. 8, Nov. 10 & Nov. 12: 7:30 a.m. to 5 p.m.
  • Nov. 9 & Nov. 11: 7:30 a.m. to 7 p.m.
  • Nov. 15, Nov. 17 & Nov. 19: 7:30 a.m. to 5 p.m.
  • Nov. 16 & Nov. 18: 2 p.m. to 7 p.m.
  • Nov. 20 (Saturday): 8 a.m. to noon.
  • Nov. 22 & Nov. 24: 7:30 a.m. to 5 p.m.
  • Nov. 23: 2 p.m. to 7 p.m.
  • Nov. 29, Dec. 1 & Dec. 3: 7:30 a.m. to 5 p.m.
  • Nov. 30 & Dec. 2: 2 p.m. to 7 p.m.

Appointments can be made by using your Patient Online Services account or by calling the Mayo Clinic Appointment line, 507-538-4040.

Phillips Hall, Siebens Building, first floor

At this location, initial or subsequent COVID-19 vaccinations, third COVID-19 doses for immunocompromised people, and COVID-19 booster vaccinations will be available on these dates:

  • Oct. 22: 7:30 a.m. to 5 p.m.
  • Oct. 25 - Oct. 29: 7:30 a.m. to 5 p.m.
  • Nov. 1 - Nov. 5: 7:30 a.m. to 5 p.m.
  • Nov. 8 - Nov. 12: 7:30 a.m. to 5 p.m.
  • Nov. 15 - Nov. 19: 7:30 a.m. to 5 p.m.

Appointments can be made by using your Patient Online Services account or by calling the Mayo Clinic Appointment line, 507-538-4040.

Available COVID-19 vaccines

Johnson & Johnson, Moderna and Pfizer COVID-19 vaccines will be offered at vaccination clinics, based on available supplies and patient. The Pfizer COVID-19 vaccine is recommended for those 12 and older. The Johnson & Johnson and Moderna COVID-19 vaccines are recommended for adults 18 and older.

The Johnson & Johnson COVID-19 vaccine is given as one dose, and the Moderna and Pfizer COVID-19 vaccines are given in a two-dose series. The second dose for Moderna is given 28 days after the first, and the second dose for Pfizer is given 21 days after the first. If you receive either of these vaccines, you will need to schedule your second dose. Schedulers are available at the vaccination clinics to help you schedule this second dose.

More information on 3rd doses for immunocompromised patients and booster vaccinations

It is now recommended that patients who are immunocompromised receive a booster vaccination 28 days after their second dose of the Moderna or Pfizer COVID-19 vaccine. In addition, a second dose vaccination of the Pfizer COVID-19 vaccine is now recommended for those are immunocompromised and received the Johnson & Johnson vaccine.


At all locations, nurses administering these COVID-19 vaccines will explain side effects, risks and benefits.

Vaccination options by Mayo Clinic location

COVID-19 vaccination options and guidelines vary widely by location, and they may change over time.

See the latest information specific to your location:


Information in this post was accurate at the time of its posting. Due to the fluid nature of the COVID-19 pandemic, scientific understanding, along with guidelines and recommendations, may have changed since the original publication date

For the safety of our patients, staff and visitors, Mayo Clinic has strict masking policies in place.  Anyone shown without a mask was either recorded prior to COVID-19 or recorded in a nonpatient care area where social distancing and other safety protocols were followed.

For more information and all your COVID-19 coverage, go to the Mayo Clinic News Network and mayoclinic.org.

Learn more about Tracking COVID-19 and COVID-19 trends.

Oct. 14, 2021- Mayo Clinic COVID-19 trending map using red color tones for hot spots