27 Genes Make Rubella Vaccine Less Effective

Using advanced genetic sequencing technology and analysis, Mayo Clinic vaccine researchers have identified 27 genes that respond in very different ways to the standard rubella vaccine, making the vaccine  less effective for a portion of the population. Mayo Clinic vaccinologist Gregory Poland, M.D., says, “This study highlighted the genes potentially responsible for poor response to the rubella vaccine. We found differences in genes responsible for antigen interactions, inflammation and differences in the gene pathways involved between low- and high-vaccine responders. It’s another instance of using individualized medicine approaches to find potential solutions for patients not benefiting from standard treatments.” The findings are in the online journal PLOS ONE.

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Sound bites with Dr. Poland are available in the downloads

Expert title for broadcast cg: Dr. Gregory Poland, Mayo Clinic Infectious Diseases