• Food allergy vs. food intolerance: What’s the difference?

calcium foods with cheeses, yogurt and a pitcher of milk on a table

Follow the symptom clues to find out whether you possibly have a food allergy or a food intolerance.

Physical reactions to certain foods are common, but most are caused by a food intolerance rather than a food allergy. A food intolerance can cause some of the same signs and symptoms as a food allergy, so people often confuse the two.

A true food allergy causes an immune system reaction that affects numerous organs in the body. It can cause a range of symptoms. In some cases, an allergic food reaction can be severe or life-threatening. In contrast, food intolerance symptoms are generally less serious and often limited to digestive problems.

If you have a food intolerance, you may be able to eat small amounts of the offending food without trouble. You may also be able to prevent a reaction. For example, if you have lactose intolerance, you may be able to drink lactose-free milk or take lactase enzyme pills (Lactaid) to aid digestion.

Causes of food intolerance include:

  • Absence of an enzyme needed to fully digest a food. Lactose intolerance is a common example.
  • Irritable bowel syndrome. This chronic condition can cause cramping, constipation and diarrhea.
  • Sensitivity to food additives. For example, sulfites used to preserve dried fruit, canned goods and wine can trigger asthma attacks in sensitive people.
  • Recurring stress or psychological factors. Sometimes the mere thought of a food may make you sick. The reason is not fully understood.
  • Celiac disease. Celiac disease has some features of a true food allergy because it involves the immune system. However, symptoms are mostly gastrointestinal, and people with celiac disease are not at risk of anaphylaxis. This chronic digestive condition is triggered by eating gluten, a protein found in wheat and other grains.

If you have a reaction after eating a particular food, see your doctor to determine whether you have a food intolerance or a food allergy.

If you have a food allergy, you may be at risk of a life-threatening allergic reaction (anaphylaxis) — even if past reactions have been mild. Learn how to recognize a severe allergic reaction and know what to do if one occurs. You may need to carry an emergency epinephrine shot (Adrenaclick, Auvi-Q, EpiPen) for emergency self-treatment.

If you have a food intolerance, your health care provider may recommend steps to aid digestion of certain foods or to treat the underlying condition causing your reaction.

This article is written by James T C Li, M.D., Ph.D. and Mayo Clinic Staff. Look for other health and medical information on mayoclinic.org.