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    Mayo Clinic: 10 Ways the Human Genome Can Affect Diagnosis and Treatment in Health

1. It's already influenced drug labels and uses for some medicines.
The U.S. Food and Drug Administration has changed medication labeling, doses and uses based on genomic research, including a key drug for breast cancer.

2. It's making sure your doctor is giving you the right drug at the right dose.
Not everyone can tolerate or metabolize the same drugs; genomics shows some medications have no effect or might hurt rather than help certain individuals. For example, one person in ten cannot tolerate the standard treatment for irritable bowel disease and needs a different drug.

3. It makes developing new medical tests faster and better.
It has already resulted in several new tests to diagnose and treat disease, and to avoid some needless therapies, including a treatment test for mood disorders.

4. It may be helping you prevent an illness.
It can tell you that you have a greater susceptibility to some conditions, so you can change your behavior to avoid them. For example, those at risk for developing diabetes can make lifestyle changes to lower their risk.

5. It may be helping you or a family member fight a treatment-resistant disease.
A genomic scan may reveal a genetic alteration that indicates an alternative, successful treatment. In one case, a mutation led to use of a kidney cancer drug to treat breast cancer.

6. It may help identify an undiagnosed disease. Misdiagnosis sometimes happens with many gene-based conditions.
Genomic analysis may pinpoint a diagnosis after months or years of confusion. For example, a person's genetic inability to produce a certain protein may mimic symptoms of a disease.

7. It may help you pick the right foods for your digestive system.
Nutrigenomics can help match your diet to your genome and help with digestive diseases, such as celiac or Crohn's disease.

8. It may help in tailoring your cancer therapy.
Your genome may not respond to certain chemotherapies, but cancer tumors also have their own modified genomes, which also need to be considered in picking a treatment. Perhaps two drugs in combination may be the solution.

9. It may help in family health decisions, including family planning.
Genomic analysis may reveal familial conditions you want to consider before having children. In some cases the two genomes may increase the risk of certain disorders.

10. Your genomic information in your medical record will help doctors diagnose and treat you in the future.
Your individual genomic signature can be as important as your blood type in determining treatment or care decisions.


About Mayo Clinic
Recognizing 150 years of serving humanity in 2014, Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit 150years.mayoclinic.org, www.mayoclinic.org and newsnetwork.mayoclinic.org.


Bob Nellis, Mayo Clinic Public Affairs, 507-284-5005, newsbureau@mayo.edu