• Biotherapeutics

    Mayo Clinic research finds spina bifida surgery before birth restores brain structure

ROCHESTER, Minn. — Surgery performed on a fetus in the womb to repair defects from spina bifida triggers the body's ability to restore normal brain structure, Mayo Clinic research discovered.

Research by Rodrigo Ruano, M.D., Ph.D., chair of Mayo Clinic's Division of Maternal and Fetal Medicine, finds that fetal surgery to correct congenital spinal cord defects is more effective at healing neurological structure than surgery after birth. This research was published in Mayo Clinic Proceedings.

"We discovered the main benefit of this procedure is not only to close the spine, but the most important thing is to improve the brain structure and the brain anatomy," says Dr. Ruano. "Our study shows we can regenerate the brain structure so that it comes back to better development."

Dr. Ruano's research focused on three last consecutive patients with myelomeningocele who underwent fetal surgery, the most common and serious form of spina bifida. Myelomeningocele is a condition in which the backbone and spinal canal do not close properly. Membranes and spinal nerves push through this opening, forming a sac and exposing tissues and nerves. This makes the baby prone to life-threatening infections.

In each case, a related neurological disorder, known as Chiari malformation, or hindbrain herniation, pushed the brain down through the base of the skull. That may lead to a buildup of fluid on the brain, causing a condition known as hydrocephalus. Oftentimes, infants with hydrocephalus require a shunt after birth to drain the fluid from the brain.

"Our hypothesis is if we closed the spinal defect in utero, we could prevent inflammation and trauma to the nerves, and most importantly stop the leakage of brain fluid through the base of the skull. And the posterior part of the brain can be restored or improved," says Dr. Ruano. "The study showed that after in utero intervention, the brain healed itself and prevented a more severe buildup of fluid on the brain."

Dr. Ruano and his team performed surgery on each of the babies to close the spinal cord opening between 23 and 26 weeks of gestation. MRI scans performed six weeks later while the babies were still in the womb showed the brain structure had been restored in each baby before birth.

The babies were delivered at 37 weeks via cesarean section with no complications. None of the babies needed a shunt to drain fluid from the brain after birth, and each baby was discharged from the hospital within three days.

Approximately 1 in every 4,000 babies, or 1,645 infants every year, are born in the United States with myelomeningocele, according to the Centers for Disease Control and Prevention. Left untreated, this type of spina bifida and Chiari malformation can lead to serious disabilities. Each case is different, but disabilities can range from bowel and bladder disorders to mobility problems and paralysis.

Future studies will be needed to investigate the benefits of open, in utero surgery, which requires a larger incision in the uterus versus fetoscopic surgery that is performed through two small incisions.


About Mayo Clinic's Center for Regenerative Medicine
Mayo Clinic's Center for Regenerative Medicine seeks to integrate, develop and deploy new regenerative medicine products and services that continually differentiate Mayo's practice to draw patients from around the world for complex care. Learn more on Mayo Clinic's Center for Regenerative Medicine website.

About Mayo Clinic Proceedings
Mayo Clinic Proceedings is a monthly peer-reviewed medical journal that publishes original articles and reviews dealing with clinical and laboratory medicine, clinical research, basic science research, and clinical epidemiology. Mayo Clinic Proceedings is sponsored by the Mayo Foundation for Medical Education and Research as part of its commitment to physician education. It publishes submissions from authors worldwide. The journal has been published for more than 90 years and has a circulation of 127,000. Visit the Mayo Clinic Proceedings website to view articles.

About Mayo Clinic
Mayo Clinic is a nonprofit organization committed to innovation in clinical practice, education and research, and providing compassion, expertise and answers to everyone who needs healing. Visit the Mayo Clinic News Network for additional Mayo Clinic news and An Inside Look at Mayo Clinic for more information about Mayo.

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