-
Mayo Clinic researchers recommend investments in vaccine safety in Nature commentary
Share this:
The leaders of Mayo Clinic's Vaccine Research Group are emphasizing the need for increased long-term study of vaccines and their mechanisms with future safety of patients in mind.
Gregory Poland, M.D., and Richard Kennedy, Ph.D., write in their commentary in the scientific journal Nature Reviews Immunology that greater focus on understanding vaccines' downstream effects, not only on immunity but also on all the other biological systems will provide information that can help make vaccines safer for all and increase public trust in vaccines.
They call for:
- Increased study of molecular, genetic and immunological mechanisms of vaccines
This will help researchers understand and avoid the adverse effects of vaccines. - Continued research on adjuvants
Adjuvants, which are substances that enhance immunity, allow researchers to fine-tune interventions to specific conditions or subsets of disease. In other words, they make targeting more accurate. - A "systems biology" approach
This approach considers all potential interactions and downstream effects that may interfere with other normal body systems. - Enhanced surveillance of participants
This surveillance would include reactions during clinical trials and in routine clinical practice long after a trial has concluded.
They say no vaccine will be completely free from risks and side effects, but by investing more research dollars in infrastructure, assessment, tracking, analysis and longitudinal studies, the safety of future vaccines ― and patient confidence in them ― can be greatly improved.
Media contact:
- Bob Nellis, Mayo Clinic Public Affairs, newsbureau@mayo.edu
Share this:
Related articles
When Joanina Gicobi began her Ph.D. degree five years ago at Mayo Clinic Graduate School of Biomedical Sciences, she was interested in thinking creatively about ways ...
With age, cells can experience senescence, a state where they stop growing but continue releasing inflammatory and tissue-degrading molecules. When a person is young, the ...
ROCHESTER, Minn. — Heart failure is a potentially urgent health concern for young adults with congenital heart disease (ACHD) that is often overlooked and undertreated, ...