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When Mike Serpe came to Mayo Clinic in December 2018, six months after undergoing chemotherapy and radiation therapy for oral cancer, he was in pain 24/7. He couldn't swallow and was getting the nutrients his body needed through a feeding tube.
"I started to have side effects from the radiation in October. I had a very sore throat, and I was coughing constantly," Mike says. "The coughing spells would take my breath away, and I had to call 911 twice."
Mike's doctor in Green Bay, Wisconsin, a former Mayo Clinic resident physician, knew otolaryngologist Daniel Price, M.D., at Mayo's Head and Neck Cancer Center. The physician called Dr. Price to make arrangements for Mike to see him at Mayo Clinic in Rochester.
When he met Mike, Dr. Price explained that the radiation and chemotherapy Mike had received to cure a cancerous tumor in his tongue had caused a condition called osteoradionecrosis.
"The condition occurs when blood supply to the bone is damaged from those cancer treatments, and the bone dies," Dr. Price says. "As it dies, it becomes infected and painful. The tissue around the bone also gets infected, and it has to be removed."
"You could barely understand what (Mike) was saying, and he was quite distressed by the level of pain."Daniel Price, M.D.
In Mike's case, the affected bone was the hyoid — a free-floating, horseshoe-shaped bone at the root of the tongue in the front of the neck. The bone injury and infection significantly affected Mike's ability to eat and swallow.
"He had very limited ability to move his tongue and had damage to the muscles of his throat from the cancer," Dr. Price says. "You could barely understand what he was saying, and he was quite distressed by the level of pain."
As they planned the next steps in Mike's care, Mike's Mayo Clinic team helped him navigate his distressing symptoms. "During December and January, I experienced the worst physical pain I've ever had," Mike says. "Thankfully, Dr. Price's staff was on top of how you do pain management. I was on six different pain medications, which put me in a state of stupor that I didn't like. They referred me to a Pain Medicine specialist who helped me wean off some of them."
Depending on the severity of the condition, treatment for osteoradionecrosis can include taking antibiotics and other medications to halt the infection. But Mike needed more than that. "He had very aggressive osteoradionecrosis, which we treat with hyperbaric oxygen therapy and surgery," Dr. Price says.
Hyperbaric oxygen therapy involves breathing pure oxygen in a pressurized room or tube. It can be used to treat a variety of conditions, including serious infections, and it helps promote healing.
The plan was for Mike to have 40 hyperbaric oxygen treatment sessions. Halfway through that series of treatments, Dr. Price would perform a debridement — a robotic surgical procedure during which he would remove Mike's hyoid bone, as well as some residual nonviable tissue that was contributing to the ongoing infection.
Mike previously had hyperbaric oxygen treatment in Green Bay. But because he had to be in a tube for that treatment, he found it extremely claustrophobic and didn't continue the treatment. Mike was able to get past that problem at Mayo Clinic, however, because he could receive hyperbaric oxygen therapy at Mayo in a larger open chamber. He also found a similar open-chamber facility closer to his home in Wisconsin, so he split his sessions between the two locations.
It was a useful way to manage the treatments, says Dr. Price. "Hyperbaric oxygen is time-intensive. You're in an oxygen chamber for an hour a day for 30 consecutive days, so it's not always easy for people to do that far from home."
As the hyperbaric oxygen therapy moved forward, Mike began to notice a difference. "Until we started the hyperbaric therapy, I was having a hard time breathing and felt horrible physically," Mike says. "As the hyperbaric treatments progressed, I was able to swallow and eat solid foods."
The hyperbaric oxygen therapy healed most of the damaged tissue. Then on March 6, Dr. Price performed surgery to remove the remaining nonviable tissue, along with the bone and a tendon. After being discharged two days later, Mike underwent ten more hyperbaric oxygen treatments near his home.
Today, Mike has put cancer and the side effects from its treatment behind him. "He's fully healed, and there's no evidence of the osteoradionecrosis or any ongoing infection," Dr. Price says.
"It's wonderful to be able to taste and enjoy all of these flavors and spices again."Mike Serpe
That's improved Mike's quality of life tremendously. Not only can he once again talk easily, without pain, he's back to enjoying his time in the kitchen, savoring cooking and eating. "I love to make chicken cacciatore, and spaghetti and meatballs. Whatever the spirit moves me," Mike says. "It's wonderful to be able to taste and enjoy all of these flavors and spices again."
For that, Mike is grateful to the team who provided his care at Mayo Clinic. "It's a small group of doctors throughout the country who treat this type of cancer and know each other, so I was very fortunate to be referred to Dr. Price," Mike says. "I would never go anywhere else for anything more serious than a hangnail. The care I received at Mayo Clinic was wonderful."
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