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Mayo Clinic researchers replicated chronic dry mouth from radiation damage in preclinical models, laying the foundation for stem cell research to regenerate salivary tissue after cancer. This discovery uses targeted X-radiation to mimic human injury and establish a lab model for testing cellular therapies for dry mouth. The study is published in Radiation Research.
"The team was satisfied to see a 50% reduction in chronic salivary function with radiation in mice — our first and major advancement toward testing salivary stem cell therapies," says Nagarajan Kannan, Ph.D., a Mayo Clinic researcher and senior co-author. "The preclinical animal model enables researchers to test the safety and long-term durable efficacy of human cell therapeutics for chronic dry mouth." Dr. Kannan is also the director of the Mayo Clinic Stem Cell and Cancer Biology Laboratory.
Mayo Clinic's Center for Regenerative Medicine supports this research as part of its objective of advancing the practice and delivering new cures for patients who have limited options.
Nearly 70% of patients with head and neck cancer who are undergoing radiation therapy experience permanent damage to their salivary glands. Increasingly, that results in chronic dry mouth, a side effect known scientifically as xerostomia.
People with this condition experience diminished quality of life from a constant feeling like cotton is lining their mouths. Treatment is limited to supportive care. Besides being uncomfortable, chronic dry mouth can lead to difficulties with chewing, tasting, speaking and swallowing. It also can cause tooth decay.
Until now, Dr. Kannan's team had limited models for testing human salivary stem cells. The development of a preclinical model provides the team with an opportunity to test whether biomanufactured epithelial stem cells could regrow salivary glands and restore saliva secretion. Epithelial cells are found lining all body surfaces, body cavities and hollow organs. They perform organ-specific function like protection, secretion, absorption, excretion, filtration, diffusion and sensory reception.
Read the rest of the article on the Center for Regenerative Biotherapeutics blog.
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