-
Science Saturday: Researchers elucidate details about the role of inflammation in liver regeneration
Share this:
The liver has the greatest regenerative capacity of any organ in the body, making it possible for surgeons to treat cancerous and noncancerous diseases with extensive surgical approaches. However, underlying chronic liver diseases, like cirrhosis or nonalcoholic steatohepatitis, are known to inhibit the liver's ability to regenerate after surgery. Without regeneration, the liver cannot function, and patients can develop postoperative liver failure — often a lethal complication.
In a recent paper published in JHEP Reports, Mayo Clinic researchers and collaborators identified that many genes rapidly change their expression during in-human liver regeneration. While most of these genes were associated with inflammation, they found patients with dysfunctional liver regeneration experience an aggravated, overwhelming inflammatory response within the liver. A certain level of inflammation is needed to spur effective liver regeneration. However, the liver fails to regenerate when there is too much of an inflammatory response.
"We were able to demonstrate that blood cells associated with inflammation, called neutrophils, play a critical role in human liver regeneration after liver resection," says Patrick Starlinger, M.D., Ph.D., a hepatobiliary and pancreas surgeon at Mayo Clinic and first author of the paper. "Until now, data from animal models have indicated that a lack of these cells is critical in liver regeneration, while an overwhelming response seems to be an issue in humans."
Read the rest of the article on the Discovery's Edge blog.
____________________________________________
Other Mayo Clinic medical research websites:
- Research at Mayo Clinic
- Advancing the Science
- Mayo Clinic Laboratories
- Forefront
- Center for Individualized Medicine
- Center for Regenerative Biotherapeutics
- Center for the Science of Health Care Delivery
- Mayo Clinic Cancer Center
Share this:
Related articles
During breaks from his doctoral research in London, Richard Vile, Ph.D., would visit a pediatric brain tumor clinic next to his lab for inspiration. Seeing children ...
A recent Mayo Clinic retrospective study shows that cancer practices can integrate telehealth without duplicative care, allowing for a more streamlined healthcare experience for patients and their ...
ROCHESTER, Minn. — Mayo Clinic researchers demonstrated a nearly 20% increase in human papillomavirus (HPV) vaccination rates among adolescents through a combination intervention approach, a ...