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coletterector

Mon, Jul 11 at 11:57am EDT by @coletterector · View  

Study: Gut Bacteria can Cause, Predict and Prevent Rheumatoid Arthritis

close-up of elderly hands

ROCHESTER, Minn. — The bacteria in your gut do more than break down your food. They also can predict susceptibility to rheumatoid arthritis, suggests Veena Taneja, Ph.D., an immunologist at Mayo Clinic’s Center for Individualized Medicine. Dr. Taneja recently published two studies ─ one in Genome Medicine and one in Arthritis and Rheumatology ─ connecting the dots between gut microbiota and rheumatoid arthritis.

More than 1.5 million Americans have rheumatoid arthritis, a disorder that causes painful swelling in the joints. Scientists have a limited understanding of the processes that trigger the disease. Dr. Taneja and her team identified intestinal bacteria as a possible cause; their studies indicate that testing for specific microbiota in the gut can help physicians predict and prevent the onset of rheumatoid arthritis.

“These are exciting discoveries that we may be able to use to personalize treatment for patients,” Dr. Taneja says.

The paper published in Genome Medicine summarizes a study of rheumatoid arthritis patients, their relatives and a healthy control group. The study aimed to find a biomarker — or a substance that indicates a disease, condition or phenomena — that predicts susceptibility to rheumatoid arthritis. They noted that an abundance of certain rare bacterial lineages causes a microbial imbalance that is found in rheumatoid arthritis patients.

MEDIA CONTACT: Colette Rector, Mayo Clinic Public Affairs, 507-284-5005, [email protected]

“Using genomic sequencing technology, we were able to pin down some gut microbes that were normally rare and of low abundance in healthy individuals, but expanded in patients with rheumatoid arthritis,” Dr. Taneja says.

Implications for predicting and preventing rheumatoid arthritis

After further research in mice and, eventually, humans, intestinal microbiota and metabolic signatures could help scientists build a predictive profile for who is likely to develop rheumatoid arthritis and the course the disease will take, Dr. Taneja says.

Based on mouse studies, researchers found an association between the gut microbe Collinsella and the arthritis phenotype. The presence of these bacteria may lead to new ways to diagnose patients and to reduce the imbalance that causes rheumatoid arthritis before or in its early stages, according to John Davis III, M.D., and Eric Matteson, M.D., Mayo Clinic rheumatologists and study co-authors. Continued research could lead to preventive treatments.

Possibility for more effective treatment with fewer side effects

The second paper, published in Arthritis and Rheumatology, explored another facet of gut bacteria. Dr. Taneja treated one group of arthritis-susceptible mice with a bacterium, Prevotella histicola, and compared that to a group that had no treatment. The study found that mice treated with the bacterium had decreased symptom frequency and severity, and fewer inflammatory conditions associated with rheumatoid arthritis. The treatment produced fewer side effects, such as weight gain and villous atrophy — a condition that prevents the gut from absorbing nutrients — that may be linked with other, more traditional  treatments.

While human trials have not yet taken place, the mice’s immune systems and arthritis mimic humans, and shows promise for similar, positive effects. Since this bacterium is a part of healthy human gut, treatment is less likely to have side effects, says study co-author Joseph Murray, M.D., a Mayo Clinic gastroenterologist.

Rheumatoid arthritis is an autoimmune disorder; it occurs when the body mistakenly attacks itself. The body breaks down tissues around joints, causing swelling that can erode bone and deform the joints. The disease can damage other parts of the body, including the skin, eyes, heart, lung and blood vessels.

The study was funded by the Mayo Clinic Center for Individualized Medicine, which supports research that aims to find treatments compatible with a patient’s unique genetic structure. It also supports the transformation of research discoveries into practical applications for patient care.

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About Mayo Clinic
Mayo Clinic is a nonprofit organization committed to clinical practice, education and research, providing expert, whole-person care to everyone who needs healing. For more information, visit http://www.mayoclinic.org/about-mayo-clinic or http://newsnetwork.mayoclinic.org/.

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lizatorborg

Tue, Jul 5 at 7:00am EDT by @lizatorborg · View  

Mayo Clinic Q and A: Treatment of Osteoarthritis

a medical illustration of two knee joints - one healthy, the other with osteoarthritis and erroded cartilage 16X9

DEAR MAYO CLINIC: My mother, 70, has osteoarthritis and was prescribed medication to help with the pain. What else can she do to keep it from worsening? Is physical therapy an option?

ANSWER: Osteoarthritis is a progressive disease that slowly gets worse over time. Although the process of osteoarthritis can’t be reversed, the symptoms usually can be effectively managed. Medication helps. Exercising regularly, staying at a healthy weight and lowering stress on joints makes a difference, too. For many people who have osteoarthritis, physical therapy is a useful part of their treatment plan.

Osteoarthritis happens when the protective cartilage that cushions the ends of bones in joints gradually breaks down. That leads to joint pain, tenderness and stiffness. Although osteoarthritis may damage any joint, it’s most common in the hands, knees, hips and spine.

As in your mother’s situation, medications such as acetaminophen and nonsteroidal anti-inflammatory drugs, or NSAIDs, frequently are used to control osteoarthritis. Several topical medications are available that can reduce joint pain, too. They include, among others, capsaicin cream and a gel form of the NSAID ibuprofen.

Exercising on a regular basis also helps ease osteoarthritis symptoms. This is where physical therapy may be useful. A physical therapist can work with your mother to create an individual exercise program to strengthen the muscles around her joints, increasing her range of motion and reducing pain.

Low-impact exercises, such as swimming, biking and walking, usually work well. Some people also enjoy activities such as tai chi and yoga, which combine gentle exercises and stretching with deep breathing. A physical therapist can help your mother decide on the activities that are right for her.

Staying at a healthy weight also is an important part of managing osteoarthritis. Carrying extra weight increases the stress on weight-bearing joints, such as the knees and hips. Even a small amount of weight loss can relieve some pressure and decrease pain. If she would like to lose weight, your mother can ask her health care provider for a referral to a dietitian. He or she can discuss healthy weight-loss strategies, offer suggestions for meal planning and provide your mother with nutritious recipes to get started.

To keep her symptoms from getting worse, your mother should try to avoid overusing the joints affected by osteoarthritis. A variety of assistive devices are available that can make everyday tasks less stressful on joints. For example, using a cane takes weight off a painful knee or hip. Gripping and grabbing tools make it easier to open doors and jars. Encourage your mother to ask her health care provider for information about these and other assistive devices that might be useful for her.

Some forms of alternative medicine have been suggested for osteoarthritis treatment, too. Acupuncture — a technique that involves inserting extremely thin needles through the skin at strategic points on the body — may contribute to pain control for some people. Meditation may also ease osteoarthritis symptoms in certain cases.

The nutritional supplements glucosamine and chondroitin often are touted as effective treatment for osteoarthritis. Results from studies on these nutritional supplements have been mixed though. A few have found benefits for people with osteoarthritis, but most have shown no clear effects. If your mother is interested in trying these supplements, encourage her to talk with her health care provider first. Glucosamine is not safe for people who are allergic to shellfish. Also, glucosamine and chondroitin may interact with blood thinners, such as warfarin, and cause bleeding problems.

Before she goes forward with any additional treatment, it would be a good idea for your mother to make an appointment to see her health care provider, talk about her options and discuss the benefits and risks of each. From there, they can create a comprehensive treatment plan that will help keep your mother’s osteoarthritis symptoms under control. Dr. John Davis III, Rheumatology, Mayo Clinic, Rochester, Minnesota

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jstreed

Sun, May 22 at 4:26pm EDT by @jstreed · View  

Awareness Saturday — Arthritis / Osteoporosis / Lupus: Mayo Clinic Radio

It's awareness Saturday on the next Mayo Clinic Radio program, as May recognizes Arthritis Awareness Month, Osteoporosis Awareness Month and Lupus Awareness Month. According to the Centers for Disease Control and Prevention, arthritis affects 1 in 5 adults in the U.S. and is a leading cause of disability among working-age adults. Mayo Clinic rheumatologist Dr. John Davis III will give an update on diagnosing and treating arthritis. Also on the program, endocrinologist Dr. Robert Wermers has an update on new treatments for osteoporosis. And, rheumatologist Dr. Vaidehi Chowdhary explains the importance of recognizing those who suffer from the chronic inflammatory disease lupus.

Here's the Mayo Clinic Radio podcast.

 

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jenohara

Thu, May 19 at 7:00am EDT by @jenohara · View  

Mayo Clinic Radio: Awareness Saturday — Arthritis / Osteoporosis / Lupus

close-up of hands with rheumatoid arthritis
It's awareness Saturday on the next Mayo Clinic Radio program, as May recognizes Arthritis Awareness Month, Osteoporosis Awareness Month and Lupus Awareness Month. According to the Centers for Disease Control and Prevention, arthritis affects 1 in 5 adults in the U.S. and is a leading cause of disability among working-age adults. Mayo Clinic rheumatologist Dr. John Davis III will give an update on diagnosing and treating arthritis. Also on the program, endocrinologist Dr. Robert Wermers has an update on new treatments for osteoporosis. And, rheumatologist Dr. Vaidehi Chowdhary explains the importance of recognizing those who suffer from the chronic inflammatory disease lupus.

Listen to the program on Saturday, May 21, at 9:05 a.m. CDT, and follow #MayoClinicRadio.

Mayo Clinic Radio is on iHeartRadio.

Access archived shows.

Mayo Clinic Radio produces a weekly one-hour radio program highlighting health and medical information from Mayo Clinic.

 

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jstreed

Wed, May 18 at 10:38am EDT by @jstreed · View  

Medication Markers for Rheumatoid Arthritis: Mayo Clinic Radio Health Minute

When it comes to treating rheumatoid arthritis, there can be lot of trial and error that can be involved before finding the best therapy.  In this Mayo Clinic Radio Health Minute, Dr. Timothy Niewold explains how researchers are hoping to change that.

To listen, click the link below.

Medication Markers for RA

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jenohara

Mon, May 16 at 2:22pm EDT by @jenohara · View  

Mayo Clinic Radio: Awareness Saturday — Arthritis / Osteoporosis / Lupus

It's awareness Saturday on the next Mayo Clinic Radio program, as May recognizes Arthritis Awareness Month, Osteoporosis Awareness Month and Lupus Awareness Month. According to the Centers for Disease Control and Prevention, arthritis affects 1 in 5 adults in the U.S. and is a leading cause of disability among working-age adults. Mayo Clinic rheumatologist Dr. John Davis III will give an update on diagnosing and treating arthritis. Also on the program, endocrinologist Dr. Robert Wermers has an update on new treatments for osteoporosis. And, rheumatologist Dr. Vaidehi Chowdhary explains the importance of recognizing those who suffer from the chronic inflammatory disease lupus.

Listen to the program on Saturday, May 21, at 9:05 a.m. CDT.

Miss the show?  Here's the Mayo Clinic Radio podcast.

Follow #MayoClinicRadio, and tweet your questions.

Mayo Clinic Radio is on iHeartRadio.

Mayo Clinic Radio produces a weekly one-hour radio program highlighting health and medical information from Mayo Clinic.

Access archived shows.

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jstreed

Thu, Mar 3 at 11:28am EDT by @jstreed · View  

Rheumatoid Arthritis and Kidney Disease: Mayo Clinic Radio Health Minute

Rheumatoid arthritis is known for it's affects on the joints, but as we learn in this Mayo Clinic Radio Health Minute, the kidney can also be at risk.

To listen, click the link below.

Rheumatoid Arthritis and Kidney Disease

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danasparks

Wed, Jan 20 at 5:02pm EDT by @danasparks · View  

Complications of Rheumatoid Arthritis

close-up of hands with rheumatoid arthritis

Rheumatoid arthritis is a chronic inflammatory disorder that typically affects the small joints in your hands and feet. Unlike the wear-and-tear damage of osteoarthritis, rheumatoid arthritis affects the lining of your joints, causing a painful swelling that can eventually result in bone erosion and joint deformity.

Complications

Rheumatoid arthritis increases your risk of developing:

  • Osteoporosis. Rheumatoid arthritis itself, along with some medications used for treating rheumatoid arthritis, can increase your risk of osteoporosis — a condition that weakens your bones and makes them more prone to fracture.
  • Carpal tunnel syndrome. If rheumatoid arthritis affects your wrist, the inflammation can compress the nerve that serves most of your hand and fingers.
  • Heart problems. Rheumatoid arthritis can increase your risk of hardened and blocked arteries, as well as inflammation of the sac that encloses your heart.
  • Lung disease. People with rheumatoid arthritis have an increased risk of inflammation and scarring of the lung tissues, which can lead to progressive shortness of breath.

Read about the symptoms, causes, treatments, risk factors and more. 

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jstreed

Tue, Jan 19 at 11:09am EDT by @jstreed · View  

Thumb Arthritis: Mayo Clinic Radio Health Minute

It can make some of the most everyday actions painful, even impossible.  In this Mayo Clinic Radio Health Minute, Dr. Sanj Kakar discusses thumb arthritis.

To listen, click the link below.

Thumb Arthritis

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lizatorborg

Nov 14, 2015 by @lizatorborg · View  

Mayo Clinic Q and A: With psoriatic arthritis, the sooner therapy is started, the better

closeup of itchy dry skin, psoriasis on elbow

DEAR MAYO CLINIC: I was recently diagnosed with psoriatic arthritis and am confused about all of the treatment options. What do you recommend for your patients?

ANSWER: Psoriatic arthritis is a type of arthritis that develops in some people who have psoriasis — a chronic skin condition characterized by thickened, reddish patches of skin that are often flecked with dry, white scales. It can cause painful, swollen joints — similar to rheumatoid arthritis. Any joint can be affected, and the pain can range from mild to severe. In both psoriasis and psoriatic arthritis, you may find that symptoms flare up, recede and then flare up again.

People with psoriatic arthritis often feel worn down by the chronic itching and pain that accompany the two diseases. Although there’s no cure, there are effective treatments that can help relieve the symptoms and even help prevent further joint damage. The sooner therapy is started, the less time the disease has to progress and cause permanent damage to your joints.  [...]

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stheimer

Nov 9, 2015 by @stheimer · View  

Deaths From Heart Disease Declining Among Rheumatoid Arthritis Patients

Rheumatoid arthritis patients are twice as likely as the average person to develop heart disease, but a new study shows that efforts to prevent heart problems and diagnose and treat heart disease early may be paying off. Despite the heightened danger, deaths from cardiovascular disease among people with rheumatoid arthritis are declining, the research found. The study was among Mayo Clinic research being presented at the American College of Rheumatology’s annual meeting in San Francisco.

Other Mayo studies discussed at the conference chronicled a significant increase in gout; examined rare intestinal microbes in rheumatoid arthritis patients; and discovered that people with rheumatoid arthritis use opioid painkillers at a hCoronary artery diseaseigher rate than the general public, but that it isn’t related to disease severity.

In the study on rheumatoid arthritis and heart disease, researchers looked at heart disease deaths within 10 years of rheumatoid arthritis diagnosis among two groups of people: 315 patients diagnosed with rheumatoid arthritis from 2000 to 2007 and 498 patients diagnosed with rheumatoid arthritis in the 1980s and 1990s. They also looked at heart disease deaths among 813 people without the rheumatic disease. Roughly two-thirds of patients studied were women, and the average age was 60.

They found a significantly lower rate of deaths from heart disease in the more recently diagnosed rheumatoid arthritis patients than in those diagnosed earlier: 2.8 percent and 7.9 percent, respectively.

Media contact: Sharon Theimer in Mayo Clinic Public Affairs, 507-284-5005 or [email protected].

[...]

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jstreed

Oct 12, 2015 by @jstreed · View  

Exercise and Osteoarthritis: Mayo Clinic Radio Health Minute

In this Mayo Clinic Radio Health Minute, Dr. Shreyasee Amin has some tips on staying active while dealing with the pain of osteoarthritis.

To listen, click the link below.

Exercise and osteoarthritis

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jstreed

Aug 24, 2015 by @jstreed · View  

Quality Health Care/Enlarged Prostate/Thumb Arthritis: Mayo Clinic Radio

Quality health care is something we all want. But what does it mean ... and how can we find it? This week on Mayo Clinic Radio, endocrinologist Dr. Victor Montori outlines the criteria you can use in choosing a quality provider. Also on the program, one of the most common problems men have as they age is an enlarged prostate gland - urologist Dr. Amy Krambeck explains how an enlarged prostate, also called benign prostatic hyperplasia, is diagnosed and treated; and severe pain, swelling and decreased range of motion in your thumb may be a sign of arthritis - orthopedic surgeon Dr. Sanjeev Kakar discusses what can be done to treat thumb arthritis.

Here's the podcast: MayoClinicRadio 08-22-15 PODCAST

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rdietman

Aug 17, 2015 by @rdietman · View  

Mayo Clinic Radio: Quality Health Care/Enlarged Prostate/Thumb Arthritis

Quality health care is something we all want. But what does it mean ... and how can we find it? This week on Mayo Clinic Radio, endocrinologist Dr. Victor Montori outlines the criteria you can use in choosing a quality provider. Also on the program, one of the most common problems men have as they age is an enlarged prostate gland - urologist Dr. Amy Krambeck explains how an enlarged prostate, also called benign prostatic hyperplasia, is diagnosed and treated; and severe pain, swelling and decreased range of motion in your thumb may be a sign of arthritis - orthopedic surgeon Dr. Sanjeev Kakar discusses what can be done to treat thumb arthritis.

Myth or Matter-of-Fact: The number of a particular procedure done each year by a provider can be one indicator of the quality.

Miss the show?  Here's the podcast: MayoClinicRadio 08-22-15 PODCAST

Follow #MayoClinicRadio and tweet your questions.

Mayo Clinic Radio is available on iHeartRadio.

Mayo Clinic Radio is a weekly one-hour radio program highlighting health and medical information from Mayo Clinic.

To find and listen to archived shows, click here.

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jstreed

Aug 5, 2015 by @jstreed · View  

CDC Arthritis Rate: Mayo Clinic Radio Health Minute

In this Mayo Clinic Radio Health Minute, Dr. Shreyasee Amin comments on numbers out from the CDC on the rates of arthritis.

To listen, click the link below.

Arthritis Rate

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jstreed

Jul 28, 2015 by @jstreed · View  

Smoking and Rheumatoid Arthritis: Mayo Clinic Radio Health Minute

Smoking can have all kinds of negative effects on your body.  Did you know that includes rheumatoid arthritis?  In this Mayo Clinic Radio Health Minute, Dr. Eric Matteson explains why.

To listen, click the link below.

Smoking and RA

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jstreed

Jul 17, 2015 by @jstreed · View  

ACL-Osteoarthritis Study: Mayo Clinic Radio Health Minute

In this Mayo Clinic Radio Health Minute, Dr. Michael Stuart explains how studying people with A-C-L injuries could help osteoarthritis patients.

To listen, click the link below.

ACL Osteoarthritis Study

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jstreed

Jul 16, 2015 by @jstreed · View  

Rethinking Rheumatoid Arthritis: Mayo Clinic Radio Health Minute

In this Mayo Clinic Radio Health Minute, Dr. John Davis discusses current and future therapies for rheumatoid arthritis.

To listen, click the link below.

Rethinking RA

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jstreed

Jun 3, 2015 by @jstreed · View  

Thumb Arthritis: Mayo Clinic Radio Health Minute

It's more common than you might imagine.  In this Mayo Clinic Radio Health Minute, Dr. Sanj Kakar fills us in on thumb arthritis.

To listen, click the link below.

Thumb Arthritis

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jstreed

Apr 17, 2015 by @jstreed · View  

Osteoarthritis and Weight: Mayo Clinic Radio Health Minute

In this Mayo Clinic Radio Health Minute, Dr. Shreyasee Amin tells us about the association between osteoarthritis and being overweight.

To listen, click the link below.

Osteoarthritis and Weight

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