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Emily Hiatt (@emilyhiatt) posted · Fri, Nov 21 5:25pm · View  

Análisis de sangre puede evitar el proceso de ensayo y error con los medicamentos en pacientes con artritis reumatoide

BOSTON: Una molécula sanguínea se muestra esperanzadora como marcador capaz de predecir si los medicamentos biológicos serían provechosos para los pacientes con artritis reumatoide o si se debería intentar con otros fármacos, revela un estudio dirigido por Mayo Clinic. La proteína, que se analiza en exámenes de sangre, puede ayudar a evitar el proceso de ensayo y error con los medicamentos, evitando no solamente que se retrase el tratamiento de los pacientes sino también efectos secundarios y costos innecesarios. La investigación es uno de varios estudios que Mayo Clinic Ilustración de una mano con artritis reumatoidepresentó durante la reunión anual del Colegio Americano de Reumatología en Boston.

Los científicos analizaron las muestras de sangre obtenidas antes de la administración del tratamiento para la artritis reumatoide. Luego, los pacientes recibieron tratamiento con medicamentos biológicos antiinflamatorios, los inhibidores del factor de necrosis tumoral alfa, que son un nuevo tipo de fármaco para la artritis reumatoide. Los científicos descubrieron  que una proteína producida por el sistema inmunitario, el interferón tipo 1, parece ser un marcador válido para saber cuáles pacientes con artritis reumatoide responderán a los medicamentos biológicos o si se debe ensayar con otros fármacos.

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Emily Hiatt (@emilyhiatt) posted · Mon, Nov 17 12:09pm · View  

El síndrome del túnel carpiano afecta a las manos y los síntomas son diferentes a los de la artritis

ESTIMADA MAYO CLINIC:
Mi trabajo exige que haga movimientos repetitivos con las manos y desde hace años tengo dolor y entumecimiento en la mano. Yo supuse que eso se debía a la osteoartritis diagnosticada hace 20 años, pero el médico piensa que puede tratarse del síndrome del túnel carpiano. ¿Existe relación entre ambas afecciones? ¿Cómo se diagnostica el síndrome del túnel carpiano?

Ilustración de una mano y del túnel carpianoRESPUESTA:
A pesar que el síndrome del túnel carpiano y la osteoartritis pueden presentarse al mismo tiempo, no existe ninguna relación entre las causas de ambas afecciones. No obstante, si le diagnostican tanto osteoartritis como síndrome del túnel carpiano, existen tratamientos para ambas afecciones.

Cuando la artritis se presenta en la mano, los dos lugares más comunes son la base del pulgar y las articulaciones próximas a las puntas de los dedos. Por su descripción, parece que usted tiene artritis del pulgar. La artritis se presenta cuando el cartílago de las articulaciones se desgasta y sin ese amortiguamiento, los extremos de los huesos rozan entre sí. Eso puede conducir a presentar una variedad de síntomas.

El síntoma más común de la artritis del pulgar es sentir dolor en la base del dedo. Otros signos y síntomas pueden incluir hinchazón, rigidez y sensibilidad en la base del pulgar, menos fuerza para agarrar algún objeto y menor amplitud de movimiento. El diagnóstico de artritis del pulgar normalmente implica revisar los síntomas y realizar exámenes por imágenes, como radiografías, que pueden mostrar la pérdida del cartílago.

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Sharon Theimer (@stheimer) posted · Mon, Nov 10 10:36am · View  

Blood Test Could Prevent Medication Trial and Error for Rheumatoid Arthritis Patients

ds00020_im02689_r7_rheumatoidarthritisthuBoston — A molecule in the blood shows promise as a marker to predict whether individual rheumatoid arthritis patients are likely to benefit from biologic medications or other drugs should be tried, a Mayo Clinic-led study shows. The protein, analyzed in blood tests, may help avoid trial and error with medications, sparing patients treatment delays and unnecessary side effects and expense. The research is among several Mayo Clinic studies presented at the American College of Rheumatology annual meeting in Boston.

Researchers tested blood samples taken before rheumatoid arthritis treatment was given. The patients then were treated with anti-inflammatory biologic drugs, tumor necrosis factor-alpha inhibitors, a new class of medications used for rheumatoid arthritis. They found that a protein made by the immune system, type 1 interferon, appears to serve as a valid marker to tell whether individual rheumatoid arthritis patients will respond to biologics, or other medications should be tried.

MEDIA CONTACT: Sharon Theimer, Mayo Clinic Public Affairs, 507-284-5005, Email: newsbureau@mayo.edu

Journalists: Sound bites of Dr. Niewold are available in the downloads below.

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lizatorborg (@lizatorborg) posted · Sat, Nov 15 6:00am · View  

Weekend Wellness: Carpal tunnel affects hands, symptoms differ from arthritis

DEAR MAYO CLINIC: I have a job in which I make repetitive movements with my hand, and have had pain and numbness in my hand for years. I assumed it was due to osteoarthritis, which I was diagnosed with 20 years ago. But my doctor thinks it may be carpal tunnel syndrome. Are the two conditions related? How is carpal tunnel syndrome diagnosed?illustration of hand with carpal tunnel

ANSWER: Although carpal tunnel syndrome and osteoarthritis can happen together, the causes of the two conditions are not related. But if you are diagnosed with osteoarthritis and carpal tunnel syndrome, effective treatments are available for both.

When you have arthritis within your hand, the two most common places to get it are the ends of the finger joints and at the base of the thumb. From your description, it sounds like you may have thumb arthritis. Arthritis happens when the cartilage in your joints wears away. Without cartilage to cushion them, the ends of the bones in the joint rub together. That can lead to a variety of symptoms. [...]

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Joel Streed (@jstreed) posted · Fri, Nov 14 8:45am · View  

Rheumatoid Arthritis and Blood Pressure: Mayo Clinic Radio Health Minute

In this Mayo Clinic Radio Health Minute, Dr. Eric Matteson comments on a study which found and association between rheumatoid arthritis and erratic blood pressure.

To listen, click the link below.

RA and Blood Pressure

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Bob Nellis (@bobnellis) posted · Thu, Nov 13 11:00am · View  

Mayo Clinic Researchers: TNF Inhibitors May Increase Cancer Risk in the Eye

Jose Pulido, M.D., senior author of the study in Mayo Clinic Proceedings.

Jose Pulido, M.D., senior author of the study in Mayo Clinic Proceedings.

ROCHESTER, Minn. — One of the family of drugs prescribed for rheumatoid arthritis and other inflammatory conditions is called TNF inhibitors. They act by dampening part of the immune system called tumor necrosis factor (TNF). In one of the balancing acts of medicine, the anti-inflammatory action of the drug also increases the risk for other conditions, in this case, a rare form of eye cancer, uveal melanoma. Mayo Clinic researchers make the case and alert physicians in an article in Mayo Clinic Proceedings.

 Mayo researchers studied three patients — two women and a man — who were treated for inflammatory disease and developed melanoma tumors in one eye within a year to two of taking TNF inhibitors. While this type of condition is probably rare, according to the researchers, there might be an increased risk if the patient has a pre-existing nevus (freckle of the eye). The women had inflammatory bowel disease; the man had rheumatoid arthritis. The studies occurred between 2009 and 2013.

Researchers say that patients considered for treatment with TNF inhibitors should first be given an eye exam to determine eye health, and any with existing conditions, such as choroidal nevus (lesions on the eye), should be monitored regularly to determine if any issues are developing.

MEDIA CONTACT:  Robert Nellis, Mayo Clinic Public Affairs, 507-284-9258, newsbureau@mayo.edu [...]

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Kevin Punsky (@kevinpunsky) posted · Mon, Nov 10 9:00am · View  

Mayo Clinic Researchers Identify First Steps in Formation of Pancreatic Cancer

Shown is a region of a pancreas with preneoplastic lesions. Red labeling indicates macrophages, green labeling indicates pancreatic acinar cells that dedifferentiate, and grey labeling indicates further progressed pancreatic lesions.

Shown is a region of a pancreas with preneoplastic lesions. Red labeling indicates macrophages, green labeling indicates pancreatic acinar cells that dedifferentiate, and grey labeling indicates further progressed pancreatic lesions.

JACKSONVILLE, Fla. — Researchers at Mayo Clinic’s campus in Jacksonville say they have identified first steps in the origin of pancreatic cancer and that their findings suggest preventive strategies to explore.

In an online issue of Cancer Discovery, the scientists described the molecular steps necessary for acinar cells in the pancreas — the cells that release digestive enzymes — to become precancerous lesions. Some of these lesions can then morph into cancer.

“Pancreatic cancer develops from these lesions, so if we understand how these lesions come about, we may be able to stop the cancer train altogether,” says the study’s lead investigator, Peter Storz, Ph.D., a cancer biologist.

he need for new treatment and prevention strategies is pressing, Dr. Storz says. Pancreatic cancer is one of the most aggressive human cancers — symptoms do not occur until the cancer is well advanced. One-year survival after diagnosis is only 20 percent. It is the fourth leading cause of cancer death in this country.

The scientists studied pancreatic cells with Kras genetic mutations. Kras produces a protein that regulates cell division, and the gene is often mutated in many cancers. More than 95 percent of pancreatic cancer cases have a Kras mutation.

The researchers detailed the steps that led acinar cells with Kras mutations to transform into duct-like cells with stem cell-like properties. Stem cells, which can divide at will, are also often implicated in cancer.

MEDIA CONTACT: Kevin Punsky, Mayo Clinic Public Affairs, 904-953-0746.
Email: punsky.kevin@mayo.edu [...]

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Joel Streed (@jstreed) posted · Wed, Nov 5 9:03am · View  

ACL-Osteoarthritis Study: Mayo Clinic Radio Health Minute

In this Mayo Clinic Radio Health Minute, Dr. Michael Stuart explains how studying people with A-C-L injuries could help osteoarthritis patients.

To listen, click the link below.

ACL Osteoarthritis Study

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