ROCHESTER, Minn. — Mayo Clinic researchers and collaborators have shown that an artificial intelligence (AI) tool can analyze routine pathology slides to help clinicians classify meningiomas, the most common primary brain tumor in adults, and better understand a patient’s risk of tumor recurrence.

The study, published in The Lancet Digital Health, demonstrates that deep learning models can support the extraction of molecular and prognostic information from standard hematoxylin and eosin, or H&E, slides — the same type of tissue images already used in routine clinical care. These insights are typically obtained through DNA methylation profiling, an advanced genetic test which provides valuable diagnostic and prognostic information but can be costly, time-consuming and is unavailable in many hospitals.

"This is one of the many studies where we can harness the strength of digital pathology by capturing the last two decades of genomic and molecular knowledge into AI algorithms," says Gelareh Zadeh, M.D., Ph.D., chair of the Department of Neurologic Surgery at Mayo Clinic in Rochester and the David C. and Flora C. Pratt Distinguished Chief Medical Officer for Mayo Clinic Platform.

Making advanced tumor insights more accessible

Meningiomas can vary widely in behavior. Some grow slowly and may never return after treatment, while others are more aggressive and more likely to recur. Understanding that risk is critical for patients and care teams deciding whether additional treatment, such as radiation therapy, may be needed after surgery.

Molecular testing can help identify which tumors are more likely to recur and which may respond differently to treatment. But these tests require specialized technology and expertise, limiting access for many patients.

Using tissue samples, pathology images and clinical data from 672 patients, researchers developed and tested AI models designed to help identify patterns linked to a tumor's biology. Drawing on multiple de-identified datasets, including data resources from Mayo Clinic Platform, the models supported classification of meningioma subtypes and recurrence risk prediction using standard pathology slides that are already part of routine patient care.

The findings suggest that, with further validation, AI-based tools could one day help clinicians obtain more detailed tumor information to inform patient care, without requiring every patient to undergo advanced genetic testing.

Helping guide treatment decisions

For patients with meningiomas, recurrence risk can influence follow-up care, imaging frequency and whether radiation therapy should be considered. The study found that AI-based predictions remained useful even after accounting for traditional clinical factors such as tumor grade, the extent to which surgery was able to remove the tumor and patient age.

Researchers also found that the AI models could identify patterns of tumor heterogeneity — differences within the same tumor — that may help explain why some tumors behave more aggressively or respond differently to treatment.

The researchers note that additional prospective studies are needed before the AI models can be used routinely in clinical care. Still, they say the findings lay the groundwork for more accessible, personalized care for patients with meningiomas — and potentially for similar AI approaches in other cancers.

As with any clinical decision-support tool, the researchers emphasize that these models would require rigorous evaluation, validation and ongoing physician oversight before being considered for routine care. "The aim is to make these algorithms readily and simply accessible for use globally, improving patient care across many healthcare settings," says Dr. Zadeh.

For a complete list of authors, disclosures and funding, review the publication.

###

About Mayo Clinic
Mayo Clinic is a nonprofit organization committed to innovation in clinical practice, education and research, and providing compassion, expertise and answers to everyone who needs healing. Visit the Mayo Clinic News Network for additional Mayo Clinic news.

About Mayo Clinic Platform
Founded on Mayo Clinic's dedication to patient-centered care, Mayo Clinic Platform enables new knowledge, new solutions, and new technologies through collaborations with health technology innovators to create a healthier world. To learn more, visit Mayo Clinic Platform at www.mayoclinicplatform.org.

Media contact:

• Tia Ford, Mayo Clinic Communications, newsbureau@mayo.edu

Related Articles