• Research

    Discovery’s Edge: Foreseeing the future of vaccines

Since the first vaccine paved the way for the near-eradication of smallpox over 200 years ago, societies have looked to vaccines as a means to stop the spread of infectious diseases. Today the same concepts are being called upon for new disease threats including Ebola and Middle East respiratory syndrome (MERS), and the continued reemergence of diseases such as influenza strains that have existing but problematic vaccines.

Gregory Poland, M.D., a founder of Mayo Clinic's Vaccine Research Group in Rochester, Minn., says the future of vaccine development must include far more than discoveries in the laboratory.

Gregory Poland, M.D.
Gregory Poland, M.D.

"Several factors have stopped vaccines from achieving their full potential in preventive medicine," says Dr. Poland. "To succeed we must recognize and address the various economic, social, and scientific barriers that have mitigated their ability to improve public health." To that end he is recommending a major bolus of public funding, improved education and a strong dose of individualized medicine.

Fixing the Developmental Pipeline

The cost to bring a new vaccine to the market is about $1 billion. Once produced, vaccines have a limited shelf life and it is often difficult to predict when they will be needed. Accordingly, the initial return on investment fails to meet the profit incentive common in Western nations until it is far too late.

"Moving forward, it is imperative to provide vaccine development mechanisms for diseases that have been neglected due to economic reasons," Dr. Poland says. "This can be achieved by complementing the efforts of the private sector with a government-sponsored global fund for developing and licensing vaccines against diseases that have the potential to be the world's next Ebola."

Addressing the Knowledge Gaps

Even if a vaccine is able to overcome the hurdles of development, there is no guarantee that patients will chose to use it. Misinformation resulting from discredited studies and rumors about the prevalence of severe side effects have significantly increased society's perceived risks of vaccine use. Dr. Poland believes the solution largely lays in improving communication.

"The truth is, severe side effects from vaccines are so rare that I cannot study them," he says. "In most circumstances, vaccination compliance issues need to be addressed through education. We must train physicians to translate evidence about side effects using a blend of analytical and emotive approaches in order to meet the distinct cognitive learning styles, and biases of patients." In other words, communication must be individualized, as one approach doesn’t work with everyone. This may change from one medical practice or one demographic to another, and certainly from culture to culture.

Individualizing Preventive Medicine

Additionally, the effectiveness of many vaccines has been limited by the "one size fits all" mentality that dominates this field of scientific research. In the current era of genomic medicine, it is naive to assume it is enough to develop and distribute one vaccine for a given disease in such a genetically diverse world. Accordingly, Dr. Poland has pioneered the scientific field of vaccinomics, which seeks to optimize vaccine responses based on patients' genetic backgrounds.

"To date, vaccine development has not deviated from a simple paradigm where viruses are isolated, inactivated, and injected. It is unbelievable when you step back as a scientist, and look at how researchers continue to use this approach despite limited success," says Dr. Poland. "At Mayo Clinic, we are seeking to understand the genetic drivers of vaccine responses so we can reverse engineer new vaccines tailored to individual needs."

December 14, 2015