Mayo Clinic has been designated a Tier 1 Center of Excellence for Telomere Biology Disorders by Team Telomere, an international organization devoted to improving the lives of those affected by these complex conditions. This recognition reinforces Mayo Clinic's commitment to enhance diagnostic precision, advance patient care and develop groundbreaking treatments. 

Telomere biology disorders, also known as short telomere syndromes or disorders, are rare diseases due to genetic mutations that accelerate shortening of telomeres, which are protective caps at the ends of chromosomes. People with these disorders often face multiple diseases such as pulmonary fibrosis, bone marrow failure, osteoporosis, various cancers and liver fibrosis. Some people experience early signs of aging, like graying hair or fragile nails. 

"Since its launch in 2016 by Mayo Clinic's Center for Individualized Medicine, the Telomere Biology Disorders clinic has rapidly developed into a leading program, now seeing 3-5 new cases each month and serving more than 126 families across its Minnesota and Arizona locations," says Mrinal Patnaik, M.B.B.S., a hematologist and director of the program. "The clinic leverages expertise from hematologists, oncologists, pulmonologists, gastroenterologists, dermatologists, liver specialists, pharmacists, molecular biologists, genetic counselors and more." 

The clinic offers a wide range of diagnostic and treatment options for patients, including: 

• Blood tests (including CBC and liver function tests) 

• Measurement of telomere length 

• Bone marrow studies  

• Lung function testing  

• Advanced imaging techniques such as CT, MRI, MRE and ultrasound 

• Contrast echocardiography and endoscopy 

• Head and neck and anogenital cancer screening 

• Hematopoietic cell transplantation 

• Lung and liver transplantation 

• DEXA scan for bone density 

• Genetic counseling and family screening  

The Tier 1 designation is part of a newly established tier system by Team Telomere that recognizes organizations demonstrating excellence in several key areas, including coordinated and comprehensive care, advocacy and collaborative research efforts.  

Mayo Clinic's status as a Tier 1 center further enhances its leading role in shaping the future of Telomere Biology Disorders management and treatment. 

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