ROCHESTER, Minn. — In 2025, Mayo Clinic advanced cures, accelerated diagnoses and expanded access to care through its Bold. Forward. strategy, introducing hundreds of innovations to better serve patients worldwide.

"Guided by our primary value of putting the needs of our patients first, 2025 was another strong year for Mayo Clinic," said Gianrico Farrugia, M.D., president and CEO. "Through our Bold. Forward. strategy, we delivered new capabilities that meaningfully improved patients’ lives and positioned us to accelerate patient-centered transformation in the year ahead."

Digital innovation and Mayo Clinic Platform

Data-powered innovations and strategic collaborations helped identify diagnoses earlier and enabled new therapies to reach patients faster. In 2025, Mayo Clinic integrated 22 Mayo Clinic Platform-driven solutions into clinical practice, enhancing AI-enabled care and streamlining workflows. For example, the PSA Control Tower supports earlier detection of prostate cancer recurrence. Also, researchers can now analyze data from thousands of glioblastoma patients in minutes rather than years.

At the same time, Mayo Clinic Platform expanded its global reach through Mayo Clinic Platform_Orchestrate, which helps biopharma and medical device companies accelerate clinical development to get patients therapies faster, and Mayo Clinic Platform_Insights, which gives healthcare organizations worldwide access to Mayo Clinic expertise and data-driven insights to overcome barriers to the responsible implementation of AI solutions.

Innovation is strongest when shaped by those closest to patients. In 2025, a multidisciplinary team led by the Department of Nursing at Mayo Clinic developed the AI-powered Nurse Virtual Assistant, created by nurses for nurses. This solution delivers patient summaries and direct links to evidence-based resources, giving nurses more time to focus on care.

These digital advances also contributed to expanded access and new collaborations. Outpatient digital visits increased 17% to 1.2 million compared to 2024. Additionally, nearly 300 technologies were licensed, and close to 200 new agreements were signed across biopharma, diagnostics and AI, expanding access to Mayo Clinic knowledge worldwide.

Accelerating research and discovery

Clinical trial activity increased 20% over 2024, with activation times cut in half for one-third of studies. Virtual trial models expanded participation and accelerated results, allowing promising therapies to reach patients faster. Researchers also advanced work in heart failure, kidney disease, Alzheimer’s disease and breast cancer, using data-driven tools to predict, prevent and treat complex diseases earlier and more precisely.

Excellence in patient care

These advances translated directly into care delivery. Mayo Clinic cared for patients from every state and more than 140 countries, including 161,590 surgical patients, an increase of more than 4% from 2024. Additionally, Mayo Clinic performed 2,065 solid-organ transplants, the most in the nation. Teams introduced 149 new surgeries and procedures and delivered more than 26 million diagnostic tests, including 100 new tests.

This commitment to excellence continued to earn national and global recognition. In 2025, Mayo Clinic was named World’s Best Hospital for the seventh consecutive year and World’s Best Smart Hospital by Newsweek. U.S. News & World Report ranked Mayo Clinic in the top three in more specialties than any other hospital for 36 straight years.

Workforce expansion

Behind this progress was continued growth in Mayo Clinic’s workforce. The organization welcomed more than 12,400 new colleagues in 2025, bringing total staff to nearly 85,000, and educated more than 5,000 students and trainees across the Mayo Clinic College of Medicine and Science.

"The work of Mayo Clinic begins and ends with our people," said Christina Zorn, chief administrative officer. "Across every role and every campus, our staff bring extraordinary skill, compassion and teamwork to patients each day. Their commitment to one another and to those we serve is what turns our strategy into action and makes our mission possible."

Building the future of healthcare: Bold. Forward. Unbound.

Investment in the future of care continued through Bold. Forward. Unbound., the $9 billion investment integrating advanced digital capabilities with modern clinical environments. Construction progressed in Rochester, including expanded proton beam therapy capacity. In Arizona, Mayo Clinic announced a major transformation of its Phoenix campus. In Florida, a new five-floor patient tower added 166 beds, and the Duan Family Building opened, bringing advanced photon and proton therapy, and the first carbon ion therapy program being built in the Americas. Mayo Clinic Health System also broke ground on a new hospital in Sparta, Wisconsin, strengthening care in rural communities.

Reflecting strong confidence in Mayo Clinic’s mission and impact, philanthropic support reached $1.47 billion in 2025, and Mayo Clinic generated $473 million in operating income, a 2.3% margin.

"Mayo Clinic exists for one reason only, to help patients," said Dr. Farrugia. "In 2025, we were able to help more people in new ways than ever before, and we will continue striving to bring even more hope and healing in 2026."

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