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Researchers Discover Stem Cell Senescence Drives Aging
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Mayo Clinic researchers have shown that adult progenitor cells , or stem cells — important for repair and regeneration of skeletal muscle and maintenance of healthy fat tissue — are subject to cellular senescence, and that clearance of these cells limits age-related deterioration of these tissues. Jan van Deursen, Ph.D., a Mayo Clinic molecular biologist and senior author of the study, says, “Earlier we discovered that senescent cells accumulate in tissues with aging and that removal of these cells delays age-related functional decline in these tissues. The key advance of the current study is that the progenitor cell populations are most sensitive for senescence, thereby interfering with the innate capacity of the tissue to counteract degeneration.”
The findings will appear online in the journal Cell Reports.
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