-
Science Saturday: Researchers find widespread sex bias in molecular biology tools
Share this:
Widely used sex-biased maps of molecular biology are holding back individualized medicine, say Mayo Clinic scientists.
______________________________________
Maps clarify how places are connected. In biology, the same is true for databases that map out how aspects of biology are connected. Different biological databases examine genes (genomics), how those gene instructions are read (transcriptomics), what is made from the gene instructions (proteomics), and how that gene product breaks down in the body (metabolomics). Called omics for simplicity, these mapping tools are routinely used in biomedical research to understand what is happening on a molecular and cellular level in normal and disease states.
While extremely useful for researchers, a Mayo Clinic-led commentary published in Nature Methods found that relying on omics tools can introduce bias related to sex differences that could contribute to misleading results.
"These tools leverage databases that summarize all known molecular interactions, the vast majority of which were discovered using male-biased study designs," says Kamila Bond, first author of the study. She is a member of the Mathematical Neuro-Oncology lab at Mayo Clinic in Arizona, led by Kristin Swanson, Ph.D., a mathematical oncologist.
While these tools are extremely popular, Bond says, the default male standard fails to account for the fundamental sex differences between males and females in biology.
Read the rest of the article on Discovery's Edge.
____________________________________________
Other Mayo Clinic medical research websites:
- Research at Mayo Clinic
- Discovery’s Edge
- Advancing the Science
- Forefront
- Mayo Clinic Center for Individualized Medicine
- Center for Regenerative Medicine
- Center for the Science of Health Care Delivery
Share this:
Related articles
World AIDS Day, observed on Dec. 1, raises awareness about HIV/AIDS and pays tribute to those affected by the disease. Globally, about 39 million people are living ...
Lung cancer is the largest cancer killer of adult men and women worldwide. One of the reasons is that by the time symptoms develop, the ...
During breaks from his doctoral research in London, Richard Vile, Ph.D., would visit a pediatric brain tumor clinic next to his lab for inspiration. Seeing children ...