ROCHESTER, Minn. — A study conducted by Mayo Clinic suggests artificial intelligence could potentially improve time efficiency and standardization for radiation therapy planning in patients with head and neck cancers. The validation study, published in Frontiers in Oncology, evaluated the efficiency of an algorithm trained by Mayo Clinic and developed in collaboration with Google Health.

Radiation therapy planning for head and neck cancers requires a heavy time investment from multiple specialty areas due to the many organs and structures in close proximity to each other and the anatomical variations of each patient. Experts from the Department of Radiation Oncology at Mayo Clinic investigated whether the algorithm could reduce the time it takes to plan treatment for head and neck cancers and improve the quality of radiation plans and patient outcomes.

In the study, radiation oncologists revised manually drawn head and neck contours, which outline organs at risk of radiation exposure, and contours automatically segmented by the deep-learning model. According to survey data collected after each review case, the deep-learning model produced contours that were ready for clinical use with minor to no revisions 90% of the time, compared to 53% of the time for manual contours, and reduced the overall contouring and process time by 76%.

"Head and neck radiation treatment planning is resource-intensive and cumbersome," says Samir Patel, M.D., a radiation oncologist at Mayo Clinic and co-principal investigator of the study. "This auto-contouring algorithm saved time in the cases we analyzed."

The model was trained using 445 de-identified CT scan contours from previously treated Mayo Clinic patients with head and neck cancer. To further refine the dataset, each contour was re-created by two Mayo Clinic head and neck radiation oncologists to meet the gold-standard criteria for radiation therapy.

This initiative is the first research collaboration in a broader initiative between Mayo Clinic and Google Health, announced in 2019, which aims to improve the delivery of care for serious and complex conditions. This strategic partnership harnesses knowledge and data to create digital tools available on innovative health care platforms that may reach patients worldwide.

"By leveraging the expertise of Mayo Clinic and Google Health, this algorithm has the potential to increase the reach of Mayo Clinic expert radiation oncologists to the global radiation oncology community," says Dr. Patel.

"This joint research demonstrates the power of Mayo Clinic and Google's collaboration, bringing together world-class radiation oncologists and medical physicists at Mayo Clinic with software engineers and researchers from Google to tackle an important issue for patients with cancer," says Cían Hughes, M.B., Ch.B., informatics lead at Google Health. "This is early-stage work, and further clinical research will be required to see how this can be safely integrated into practice."

The next phase of research will investigate the efficiency of the algorithm outside of Mayo Clinic.

"Mayo Clinic is planning future collaborations with other institutions to demonstrate that the model performs efficiently in their environments," says Joseph (John) Lucido III, Ph.D., co-principal investigator of the study.

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About Mayo Clinic Comprehensive Cancer Center
Designated as a comprehensive cancer center by the National Cancer Institute, Mayo Clinic Comprehensive Cancer Center is defining new boundaries in possibility, focusing on patient-centered care, developing novel treatments, training future generations of cancer experts, and bringing cancer research to communities. At Mayo Clinic Comprehensive Cancer Center, a culture of innovation and collaboration is driving research breakthroughs that are changing approaches to cancer prevention, screening, and treatment and improving the lives of cancer survivors.

About Mayo Clinic
Mayo Clinic is a nonprofit organization committed to innovation in clinical practice, education and research, and providing compassion, expertise and answers to everyone who needs healing. Visit the Mayo Clinic News Network for additional Mayo Clinic news.

Media contact:

• Jessica Saenz, Mayo Clinic Communications, newsbureau@mayo.edu

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