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Cancer
Florescence-guided surgery: Making the invisible visible
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In this episode of "Tomorrow's Cure," Lindsay Sievert talks with Stephanie Polites, M.D., a pediatric surgeon at Mayo Clinic, and Timothy Lautz, M.D., a pediatric surgeon and surgical oncologist at Lurie Children's Hospital of Chicago, about how fluorescent imaging is helping guide safer, more precise surgery.
The approach uses fluorescent agents and specialized cameras to make structures glow on a screen. Depending on the procedure, surgeons may use the technology to assess blood flow, identify bile ducts, locate lymph nodes, protect structures such as the ureter or help find tumors.
"What fluorescence-guided surgery does is essentially make different structures, organs and tumors glow that allows the human eye to see it in a way that wouldn't otherwise be able to do," says Dr. Polites.
The technology is especially promising in pediatric cancer surgery. Small tumors or areas where cancer has spread can be difficult to see, particularly during minimally invasive procedures. Fluorescence imaging can provide surgeons with additional information as they work to remove cancer while preserving as much healthy tissue as possible.
Dr. Polites and Dr. Lautz also are studying newer, more targeted fluorescent substances in children. These contrast substances are designed to highlight cancer cells more specifically than earlier dyes. Their clinical trials are evaluating the contrasts' safety, appropriate dosing and whether the technology helps surgeons identify tumor tissue more accurately.
The physicians describe this as part of a move toward precision surgery, using a child’s tumor biology to guide surgical care. "Different medications are becoming more precise and more tailored to a patient's individual biology and genetics. We're doing the same with surgery, and you're incorporating the individual biology of the different tumors into surgical care. And it just allows us to be more targeted and more precise," says Dr. Polites.
Although the technology shows promise, fluorescence-guided surgery is not a cure or a replacement for surgical judgment. Instead, it is another tool that may help surgeons operate more safely, remove tumors more completely and reduce the risk of long-term effects for children.
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